Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Debra D. Pittman"'
Autor:
Debra D. Pittman, Swapnil Rakhe, Sheryl R. Bowley, Reema Jasuja, Amey Barakat, John E. Murphy
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 2, Pp n/a-n/a (2022)
Abstract Background Patients with hemophilia have deficiencies in intrinsic coagulation factors and can develop inhibitors that limit the effectiveness of replacement coagulation factors. Marstacimab, a human monoclonal antibody, binds and inhibits t
Externí odkaz:
https://doaj.org/article/9566ad6dee764463b3deaef1e57ac56b
Autor:
Karin S. Coyne, Brooke M. Currie, Michael Callaghan, Kathleen W. Wyrwich, Sheryl Pease, Christine L. Baker, Steven Arkin, Debra D. Pittman
Publikováno v:
European Journal of Haematology. 109:226-237
Individuals with sickle cell disease (SCD) experience vaso-occlusive crises (VOC). Historically, VOC episodes have been assessed through medical utilization, thereby excluding events managed at home. In order to validate a daily patient-reported outc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb7f30f02c1b3c72f482401d4bdf223
https://doi.org/10.1111/ejh.13790
https://doi.org/10.1111/ejh.13790
Autor:
Hongwei Li, Jin Zhong Li, Debra D. Pittman, Andy Amalfitano, Gerald R. Hankins, Gregory A. Helm
Publikováno v:
International Journal of Medical Sciences, Vol 3, Iss 3, Pp 97-105 (2006)
Osteogenic potentials of some recombinant human bone morphogenetic protein (BMP) first-generation adenoviral vectors (ADhBMPs) are significantly limited in immunocompetent animals. It is unclear what role expression of viral proteins and foreign prot
Externí odkaz:
https://doaj.org/article/018b2ffeee8d4e399761d6725f88766a
Autor:
Donald F. Brophy, John E. Murphy, Debra D. Pittman, Bassem M. Mohammed, John C. Barrett, Janice Kuhn, Swapnil Rakhe, Pengling Sun, Erika J. Martin, Sunita Patel-Hett, Melinda E Nolte
Publikováno v:
Haemophilia. 25:797-806
Introduction Tissue factor pathway inhibitor (TFPI) is an endogenous inhibitor of the extrinsic pathway that negatively regulates thrombin production during coagulation. Under haemophilic conditions, where the intrinsic coagulation pathway is impaire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4f20f573bbf34091fa95cc154a39eb
https://doi.org/10.1111/hae.13820
https://doi.org/10.1111/hae.13820
Autor:
Xiufeng Gao, Alan D. Michelson, Andrew L. Frelinger, Denis Rybin, Ke Liu, Michael U. Callaghan, David Beidler, Jennell White, Robert J Charnigo, Patrick C. Hines, Debra D. Pittman, Ahmar U. Zaidi
Publikováno v:
Blood. 137(15)
Clinical trials in sickle cell disease (SCD) often focus on health care utilization for painful vaso-occlusive crises (VOCs). However, no objective, quantifiable pain biomarkers exist, pain is not specific to VOCs, health care utilization varies betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9392b6a1aab3930604aa5efef83c6243
https://pubmed.ncbi.nlm.nih.gov/33856439
https://pubmed.ncbi.nlm.nih.gov/33856439
Autor:
Chuenlei Parng, James S. O’Donnell, Matthew Allister Lambert, Orla Cunningham, Judicael Fazavana, Teresa M. Brophy, Justin Cohen, Alain Chion, Niamh M. Cooke, Jamie M. O’Sullivan, Virginie Terraube, Debra D. Pittman
Publikováno v:
J Thromb Haemost
Background Previous studies have demonstrated that the A1A2A3 domains of von Willebrand factor (VWF) play a key role in regulating macrophage-mediated clearance in vivo. In particular, the A1-domain has been shown to modulate interaction with macroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a44ea40849d3b886e90570abe46961
https://pubmed.ncbi.nlm.nih.gov/32108991
https://pubmed.ncbi.nlm.nih.gov/32108991
Autor:
John E. Murphy, P. Sun, Tong Zhu, Steven Arkin, Debra D. Pittman, M. Cardinal, Constantino Kantaridis
Publikováno v:
Journal of Thrombosis and Haemostasis. 16:1722-1731
Essentials Tissue factor pathway inhibitor (TFPI) is an antagonist of FXa and the TF-FVIIa complex. PF-06741086 is an IgG1 monoclonal antibody that targets the Kunitz-2 domain of TFPI. Single doses of PF-06741086 were evaluated in a phase 1 study in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7454b9974e833d4459a097c4d228b2
https://doi.org/10.1111/jth.14207
https://doi.org/10.1111/jth.14207
Autor:
Chuenlei Parng, Boris Gorovits, Rob Webster, Teresa M Caiazzo, Nicole Duriga, Debra D. Pittman, Michael W. Bolt, Alison Joyce, Beth A. Leary, Victoria Markiewicz, Jianqing Chen, Lisa Dyleski
Publikováno v:
Journal of Pharmaceutical Sciences. 106:2136-2143
FXaI16L is a recombinant human FXa variant which is currently being evaluated in the clinic for treating intracerebral hemorrhage. The aim of our studies is to investigate overall pharmacokinetics, pharmacodynamics, and distribution of FXaI16L in pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa0aa25dfea0ee3ee0f2b82522f66191
https://doi.org/10.1016/j.xphs.2017.03.035
https://doi.org/10.1016/j.xphs.2017.03.035
Publikováno v:
Journal of Thrombosis and Haemostasis. 15:931-937
Essentials FXaI16L is a recombinant zymogen-like variant of activated coagulation factor X (FXa). A phase 1 dose escalation clinical trial of FXaI16L was conducted in healthy adults. FXaI16L was safe and tolerated at doses up to 5 μg/kg; no dose-lim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4468cd8fcade323846621d76ee09528e
https://doi.org/10.1111/jth.13673
https://doi.org/10.1111/jth.13673
Autor:
Simon J. Draper, João Arezes, Anagha Sawant, John E. Murphy, Orla Cunningham, Kirsty McHugh, Matthew Allister Lambert, Hal Drakesmith, Niall J. Foy, May S. Tam, Debra D. Pittman, Reema Jasuja, Doris Quinkert, Pei Jin Lim, Joe N. Frost, Susan Benard, Edward R. Lavallie, Sant-Rayn Pasricha, Andrew E. Armitage
Publikováno v:
Blood
Erythroferrone (ERFE) is produced by erythroblasts in response to erythropoietin (EPO) and acts in the liver to prevent hepcidin stimulation by BMP6. Hepcidin suppression allows for the mobilization of iron to the bone marrow for the production of re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a9fdb452e4f94fdcfb6f8436c36ed0
https://pubmed.ncbi.nlm.nih.gov/32078688
https://pubmed.ncbi.nlm.nih.gov/32078688