Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Debra D, Donaldson"'
Autor:
N. Wood, M. O'Toole, Debra D. Donaldson, A.A. Hill, H. Legault, M. K. Ramarao, C.M. McKee, Marion T. Kasaian, G. Bensch, James R. Baker, G. W. Bensch, D. K. Ellis, C. Hang, C. Csimma, Padmalatha S. Reddy, A. J. Dorner, K. A. Whalen, J. D. Clark, J.L. Ryan
Publikováno v:
Clinical & Experimental Allergy. 38:1590-1605
Background Existing treatments for asthma are not effective in all patients and disease exacerbations are common, highlighting the need for increased understanding of disease mechanisms and novel treatment strategies. The leukotriene pathway includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c54454c589b1b7e83c767ea64e0eb763
https://doi.org/10.1111/j.1365-2222.2008.03059.x
https://doi.org/10.1111/j.1365-2222.2008.03059.x
Autor:
Kimberly Ann Marquette, Joseph P. Sypek, Rustem Krykbaev, Michael D Wadanoli, Franklin J. Schlerman, Marion T. Kasaian, Suresh Vunnum, Wood Nancy L, Bruce A. Jacobson, Lioudmila Tchistiakova, Andrea G Bree, Timothy A. Cook, Xin Xu, Xiang-Yang Tan, Samuel J. Goldman, Angela Widom, Debra D. Donaldson
Publikováno v:
Journal of Allergy and Clinical Immunology. 119:1251-1257
Background Airway inflammation is a hallmark feature of asthma and a driver of airway hyperresponsiveness. IL-13 is a key inducer of airway inflammation in rodent models of respiratory disease, but a role for IL-13 has not been demonstrated in primat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f22fd41ec804b9e3b31d0b9ca5da3e
https://doi.org/10.1016/j.jaci.2007.02.009
https://doi.org/10.1016/j.jaci.2007.02.009
Autor:
Anthony Barry, Ashfaq Ahmed, Lioudmila Tchistiakova, Bruce A. Jacobson, Timothy A. Cook, Debra D. Donaldson, Kimberly Ann Marquette, Samuel J. Goldman, Xin Xu, Angela Widom, Xiang Yang Tan, William M. Abraham, Marion T. Kasaian
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 36:368-376
IL-13 contributes to airway hyperresponsiveness, mucus secretion, inflammation, and fibrosis, suggesting that it plays a central role in asthma pathogenesis. Neutralization of IL-13 with sIL-13Ralpha2-Fc (sIL-13R) reduces allergen-induced airway resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a2d19b8e8b3fb34481add971d16c84
https://doi.org/10.1165/rcmb.2006-0244oc
https://doi.org/10.1165/rcmb.2006-0244oc
Publikováno v:
The Journal of Immunology. 174:7716-7724
IL-4 and IL-13 are potent cytokines that drive production of IgE, which is critical to the development of atopic disease. In this study, we directly compared IgE generation and IgE-dependent mast cell effector function in mouse strains lacking IL-4,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd38fa5fde6b83f6cd88f5d019d62c9
https://doi.org/10.4049/jimmunol.174.12.7716
https://doi.org/10.4049/jimmunol.174.12.7716
Autor:
Kaushik Parthasarathi, Kesha Robinson, Debra D. Donaldson, Gabriele Grunig, Viswanath P. Kurup, Andrew Neil James Mckenzie, Eleen Daley, Anthony Chow, Thomas Tschernig, Jocelyn Padilla
Publikováno v:
The Journal of Immunology. 174:8097-8105
The large inhibitory effect of IL-13 blockers on the asthma phenotype prompted us to ask whether IL-13 would play a role in regulating the allergic immune response in addition to its documented effects on structural pulmonary cells. Because IL-13 doe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69149fdbcecd40aadce0586e29aaca62
https://doi.org/10.4049/jimmunol.174.12.8097
https://doi.org/10.4049/jimmunol.174.12.8097
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 170:851-856
Interleukin (IL)-13 is regarded as being a central effector in the pathophysiology of airway hyperresponsiveness. We have described a mouse model in which chronic allergen exposure results in sustained airway hyperresponsiveness and aspects of airway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9d82e294a86d0f03d4b5f5ab8c826c
https://doi.org/10.1164/rccm.200311-1488oc
https://doi.org/10.1164/rccm.200311-1488oc
Autor:
Marion T. Kasaian, Debra D. Donaldson, Karen Bourque, Wood Nancy L, Mary Collins, Samuel J. Goldman, Donata Vercelli
Publikováno v:
Cellular Immunology. 231:133-145
In human atopic disease, IgE sensitizes the allergic response, while IgG4 is protective. Because IL-4 and IL-13 trigger switch recombination to both IgE and IgG4, additional agents must regulate the balance between these isotypes to influence suscept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67fe491b84af0570874c61939c09b70a
https://doi.org/10.1016/j.cellimm.2005.01.001
https://doi.org/10.1016/j.cellimm.2005.01.001
Autor:
Lenny D. Shultz, Azzeddine Dakhama, Nobuaki Miyahara, Debra D. Donaldson, Simona Zarini, Eckard Hamelmann, Joan E. Loader, Katsuyuki Takeda, Xudong Wei, Tricia N. Lively, Taku Kodama, Christian Taube, Erwin W. Gelfand, Anthony Joetham, Christina H. Swasey
Publikováno v:
The Journal of Immunology. 172:6398-6406
In certain models of allergic airway disease, mast cells facilitate the development of inflammation and airway hyper-responsiveness (AHR). To define the role of the high affinity IgE receptor (FcεRI) in the development of AHR, mice with a disruption
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb1466c6da39b360a7d47dae89caa6c
https://doi.org/10.4049/jimmunol.172.10.6398
https://doi.org/10.4049/jimmunol.172.10.6398
Autor:
Debra D. Donaldson, Yeping Cai, Klaus I. Matthaei, Dianne C. Webb, Surendran Mahalingam, Paul S. Foster
Publikováno v:
European Journal of Immunology. 33:3377-3385
The pathogenesis of human asthma and the development of key features of pulmonary allergy in mouse models has been critically linked to IL-13. Analyses of the receptor components employed by IL-13 have shown that delivery of this cytokine to the airw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b42f8f181a7040bd67244bb7f82ce9
https://doi.org/10.1002/eji.200324178
https://doi.org/10.1002/eji.200324178
Autor:
William E. Paul, Bruce Pratt, Debra D. Donaldson, Sharon M. Wahl, So Matsui, Jay A. Berzofsky, Mizuko Mamura, Masaki Terabe, Nancy Noben-Trauth, Wanjun Chen, Steven R. Ledbetter, Jong-Myun Park, John J. Letterio
Publikováno v:
Journal of Experimental Medicine. 198:1741-1752
Our previous work demonstrated that cytotoxic T lymphocyte (CTL)-mediated tumor immunosurveillance of the 15-12RM tumor could be suppressed by a CD1d-restricted lymphocyte, most likely a natural killer (NK) T cell, which produces interleukin (IL)-13.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c00db1dd456d8f40bd46c27c1472b63
https://doi.org/10.1084/jem.20022227
https://doi.org/10.1084/jem.20022227