Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Debra C. DuBois"'
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197258 (2018)
Circadian information is maintained in mammalian tissues by a cell-autonomous network of transcriptional feedback loops that have evolved to optimally regulate tissue-specific functions. An analysis of daily gene expression in different tissues, as w
Externí odkaz:
https://doaj.org/article/fc4493b634cc4775ad87e3f3782d68e7
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197534 (2018)
Circadian clocks, present in almost all cells of the body, are entrained to rhythmic changes in the environment (e.g. light/dark cycles). Genes responsible for this timekeeping are named core-clock genes, which through transcriptional feedback intera
Externí odkaz:
https://doaj.org/article/a040e04d72204dd8a0370216abd484e2
Autor:
William J. Jusko, Panteleimon D. Mavroudis, Alison Acevedo, Ioannis P. Androulakis, Debra C. DuBois, Richard R. Almon
Publikováno v:
J Pharmacokinet Pharmacodyn
A computational framework is developed to enable the characterization of genome-wide, multi-tissue circadian dynamics at the level of “functional groupings of genes” defined in the context of signaling, cellular/genetic processing and metabolic p
Publikováno v:
J Pharmacol Exp Ther
The pharmacokinetics (PK) of prednisolone (PNL) exhibit nonlinearity related to plasma protein binding, tissue binding, metabolic interconversion with prednisone (PN), and renal elimination. Blood and 11 tissues were collected from male Wistar rats a
Publikováno v:
J Pharmacol Exp Ther
The plasma and tissue binding properties of two corticosteroids, dexamethasone (DEX) and methylprednisolone (MPL), were assessed in the rat in anticipation of developing physiologically based pharmacokinetic and pharmacokinetic/pharmacodynamic models
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81679 (2013)
A retrospective meta-modeling analysis was performed to integrate previously reported data of glucocorticoid (GC) effects on glucose regulation following a single intramuscular dose (50 mg/kg), single intravenous doses (10, 50 mg/kg), and intravenous
Externí odkaz:
https://doaj.org/article/7aaf522b37ae4745989d4320ce1210be
Publikováno v:
Pharmaceutical research. 37(6)
Lymphocyte proliferation is a major factor determining the magnitude of the immune response. Both dexamethasone (DEX) and tofacitinib (TOF) exert marked immunosuppressive effects and are mainstay drugs in the treatment of rheumatoid arthritis (RA). T
Autor:
Vivaswath S. Ayyar, Jun Qu, Siddharth Sukumaran, William J. Jusko, Richard R. Almon, Debra C. DuBois
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 45:557-575
A multiscale pharmacodynamic model was developed to characterize the receptor-mediated, transcriptomic, and proteomic determinants of corticosteroid (CS) effects on clinically relevant hepatic processes following a single dose of methylprednisolone (
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17386 (2011)
Type 2 diabetes (T2DM) is a heterogeneous group of diseases that is progressive and involves multiple tissues. Goto-Kakizaki (GK) rats are a polygenic model with elevated blood glucose, peripheral insulin resistance, a non-obese phenotype, and exhibi
Externí odkaz:
https://doaj.org/article/503c5b0df78844aca2b2aacb33979846
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e5992 (2009)
One of the challenges in exploiting high throughput measurement techniques such as microarrays is the conversion of the vast amounts of data obtained into relevant knowledge. Of particular importance is the identification of the intrinsic response of
Externí odkaz:
https://doaj.org/article/6cd491aa974f47aaa230250c71e8b529