Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Debra C Alperin"'
Autor:
Deirdre R Ducken, Wendy C Brown, Debra C Alperin, Kelly A Brayton, Kathryn E Reif, Joshua E Turse, Guy H Palmer, Susan M Noh
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129309 (2015)
Anaplasma marginale is a tick-borne rickettsial pathogen of cattle with a worldwide distribution. Currently a safe and efficacious vaccine is unavailable. Outer membrane protein (OMP) extracts or a defined surface protein complex reproducibly induce
Externí odkaz:
https://doaj.org/article/1c722dbe540547feaf55bcdb89ce336c
Publikováno v:
Frontiers in Tropical Diseases, Vol 5 (2024)
Bovine anaplasmosis, caused by Anaplasma marginale, is one of the most common tick-borne diseases of cattle and has a worldwide distribution. The high costs of bovine anaplasmosis are due to treatment, decreased production, and outbreaks resulting in
Externí odkaz:
https://doaj.org/article/b5f112be990940fd990f7b59f8ee5b0d
Autor:
Stephen A. Hines, Guy H. Palmer, Melissa T. Hines, Debra C. Alperin, Donald P. Knowles, A. Marianela Lopez
Publikováno v:
Vaccine. 21:3815-3825
Rhodococcus equi remains one of the most important pathogens of early life in horses, yet conventional vaccines to prevent rhodococcal pneumonia have not been successful. DNA vaccination offers an alternative to conventional vaccines with specific ad
Publikováno v:
Clinical and Vaccine Immunology. 9:1270-1276
Rhodococcus equi infects and causes pneumonia in foals between 2 and 4 months of age but does not induce disease in immunocompetent adults, which are immune and remain clinically normal upon challenge. Understanding the protective response against R.
Autor:
Robert H. Mealey, Robson G. Dossa, Stephen A. Hines, Gurdyal S. Besra, Wendy C. Brown, Debra C. Alperin, Liam R. Cox, Diana Garzón, Peter J. Jervis
Publikováno v:
Developmental and comparative immunology. 49(1)
α-GalCer is a potent immunomodulatory molecule that is presented to NKT cells via the CD1 antigen-presenting system. We hypothesized that when used as an adjuvant α-GalCer would induce protective immune responses against Rhodococcus equi, an import
Autor:
Barbara A. Byrne, Debra C. Alperin, Vivian M. Nicholson, Stephen A. Hines, Shinji Takai, John F. Prescott, Guy H. Palmer
Publikováno v:
Infection and Immunity. 69:650-656
Rhodococcus equicauses severe pyogranulomatous pneumonia in foals. This facultative intracellular pathogen produces similar lesions in immunocompromised humans, particularly in AIDS patients. Virulent strains ofR. equibear a large plasmid that is req
Publikováno v:
Immunogenetics. 66(1)
The CD1 family is a group of non-polymorphic MHC class I-like molecules that present lipid-based antigens to T cells. Previous work in our laboratory demonstrated that cytotoxic T lymphocytes from immune adult horses recognize lipids from the cell wa
Publikováno v:
Journal of the American Veterinary Medical Association. 232(7)
Objective—To characterize the magnitude and duration of the antibody response against human albumin (HA) in critically ill and healthy dogs. Design—Cohort and cross-sectional study. Animals—Fourteen critically ill dogs that received 25% HA as p
Autor:
Steven R. Leib, Debra C. Alperin, Robert H. Mealey, Melissa T. Hines, S.E. Leach, Stephen A. Hines, Matt H. Littke, Diana M. Stone
Publikováno v:
Vaccine. 25(43)
Improving the ability of DNA-based vaccines to induce potent Type1/Th1 responses against intracellular pathogens in large outbred species is essential. Rhodoccocus equi and equine infectious anemia virus (EIAV) are two naturally occurring equine path
Autor:
Teresa Y. Luther, Debra C. Alperin, Kevin K. Lahmers, Linda G. Martin, A Heather Francis, Stephen A. Hines, Gary J. Haldorson
Publikováno v:
Journal of the American Veterinary Medical Association. 230(6)
Case Description—6 healthy dogs given human albumin solution as part of a study were examined following development of an immediate hypersensitivity reaction (1 dog) and signs suggestive of a type III hypersensitivity reaction (all 6 dogs). Clinica