Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Debra A. Horstman"'
Publikováno v:
Journal of Biological Chemistry. 274:2786-2793
The kinetics of PI-PLCγ1 toward a water-soluble substrate (inositol 1,2-cyclic phosphate, cIP) and phosphatidylinositol (PI) in detergent mixed micelles were monitored by31P NMR spectroscopy. That cIP is also a substrate (K m = ∼15 mm) implies a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b847cdc81b4405c222afdbd82f43d45c
https://doi.org/10.1074/jbc.274.5.2786
https://doi.org/10.1074/jbc.274.5.2786
Autor:
Debra A. Horstman, Ron Wisdom, Glenn E. Winnier, Kevin D. Niswender, Graham Carpenter, Mark A. Magnuson, Qun Sheng Ji
Publikováno v:
Proceedings of the National Academy of Sciences. 94:2999-3003
The activation of many tyrosine kinases leads to the phosphorylation and activation of phospholipase C-γ1 (PLC-γ1). To examine the biological function of this protein, homologous recombination has been used to selectively disrupt the Plcg1 gene in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23012b240fc023e8462fa24bf5c09798
https://doi.org/10.1073/pnas.94.7.2999
https://doi.org/10.1073/pnas.94.7.2999
Publikováno v:
Biochemical Journal. 273:541-546
Various experimental strategies were employed in an effort to explain the previously reported [Horstman, Takemura & Putney (1988) J. Biol. Chem. 263, 15297-15303] paradoxically high levels of inositol 1,4,5-trisphosphate [(1,4,5)IP3] in resting and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46f139f9b096b16a1f6382fc9341f42
https://doi.org/10.1042/bj2730541
https://doi.org/10.1042/bj2730541
Publikováno v:
Journal of Biological Chemistry. 265:21590-21595
The residue involved in sodium regulation of G-protein-coupled receptors has been identified by site-directed mutagenesis of the alpha 2-adrenergic receptor gene. Mutation of Asp-79 to Asn-79 entirely eliminates allosteric regulation of ligand bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54e902305c675d63771d0f0866ab7647
https://doi.org/10.1016/s0021-9258(18)45781-x
https://doi.org/10.1016/s0021-9258(18)45781-x
Publikováno v:
Journal of Biological Chemistry. 265:17307-17317
The gene for an alpha 2-adrenergic receptor has been cloned from a porcine genomic library, using as a probe a 0.95-kilobase Pst fragment of the gene for the human platelet alpha 2-adrenergic receptor. The identity of the cloned porcine gene was conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::add43bb763b12e636526c1f9dec1a2ca
https://doi.org/10.1016/s0021-9258(17)44904-0
https://doi.org/10.1016/s0021-9258(17)44904-0
Publikováno v:
American Peptide Symposia ISBN: 0792351606
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57a72e32fe08a80c91d30e20260be262
https://doi.org/10.1007/0-306-46862-x_225
https://doi.org/10.1007/0-306-46862-x_225
Publikováno v:
Archives of biochemistry and biophysics. 361(1)
Phospholipase C-gamma1, a substrate for many growth factor receptor and nonreceptor tyrosine kinases, produces second messenger molecules that are elements of signal transduction pathways related to cell proliferation. The influence of deletion mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d445dbb16c00c1e1292c31f6db3043e4
https://pubmed.ncbi.nlm.nih.gov/9882440
https://pubmed.ncbi.nlm.nih.gov/9882440
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 93(15)
The X and Y domains of phospholipase C (PLC)-gamma1, which are conserved in all mammalian phosphoinositide-specific PLC isoforms and are proposed to interact to form the catalytic site, have been expressed as individual hexahistidine-tagged fusion pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f11a03b09c5dfd9240e847dd3139d2
https://pubmed.ncbi.nlm.nih.gov/8755506
https://pubmed.ncbi.nlm.nih.gov/8755506
Publikováno v:
Science (New York, N.Y.). 257(5072)
The alpha 2A-adrenergic receptor (adrenoceptor) was stably expressed in AtT20 mouse pituitary tumor cells; adrenoceptor agonists inhibited adenylyl cyclase, inhibited voltage-dependent calcium currents, and increased inwardly rectifying potassium cur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0199701d3b0bb8e3b51a2efdb09c7702
https://pubmed.ncbi.nlm.nih.gov/1354394
https://pubmed.ncbi.nlm.nih.gov/1354394
Autor:
Gary S. Bird, Debra A. Horstman, Kerry G. Oliver, Frank S. Menniti, Arlene R. Hughes, James W. Putney, Hiroshi Sugiya, Katsumi Nogimori, Haruo Takemura, J. F. Obie
Publikováno v:
Annals of the New York Academy of Sciences. 632
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4312291e128a1c8ad743cff0e2b49630
https://pubmed.ncbi.nlm.nih.gov/1719914
https://pubmed.ncbi.nlm.nih.gov/1719914