Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Debra A. Gearhart"'
Publikováno v:
Neurobiology of Disease, Vol 7, Iss 3, Pp 201-211 (2000)
Enzymatic β-carboline N-methyltransferase activities generate N-methylated β-carbolinium cations that are analogs of the parkinsonian-producing neurotoxin MPP+. We measured β-carboline-2N-methyltransferase and β-carboline-9N-methyltransferase act
Externí odkaz:
https://doaj.org/article/9fed7818268446559117bb50527fd487
Autor:
Michael G. Bartlett, Debra A. Gearhart, Mary-Louise Middlemore, Samantha E. Warner, Sahebarao P. Mahadik, Guodong Zhang, Elizabeth J. Hohnadel, Alvin V. Terry
Publikováno v:
Neuroscience. 150:413-424
The primary therapeutic agents used for schizophrenia, antipsychotic drugs, ameliorate psychotic symptoms; however, their chronic effects on cognition (or the physiologic processes of the brain that support cognition) are largely unknown. The purpose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfed674c921d2d393c26af14a6356fc
https://doi.org/10.1016/j.neuroscience.2007.09.014
https://doi.org/10.1016/j.neuroscience.2007.09.014
Autor:
Wayne D. Beck, Samantha E. Warner, Jennifer L. Waller, Guodong Zhang, Michael G. Bartlett, Mary-Louise Middlemore, Debra A. Gearhart, Alvin V. Terry, Sahebarao P. Mahadik
Publikováno v:
Neuroscience. 146:1316-1332
First and second generation antipsychotics (FGAs and SGAs) ameliorate psychotic symptoms of schizophrenia, however, their chronic effects on information processing and memory function (i.e. key determinants of long term functional outcome) are largel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab67f2c9098a52b8c9be08c9e427668
https://doi.org/10.1016/j.neuroscience.2007.03.003
https://doi.org/10.1016/j.neuroscience.2007.03.003
Autor:
Alvin V. Terry, Jerry J. Buccafusco, L. Ghayoumi, Debra A. Gearhart, M.M. Mullins, Mark A. Prendergast, Rachel L. Self, Katherine J. Smith, Tracy Butler
Publikováno v:
Neuroscience. 146:330-339
Prolonged exposure to organophosphate (OP) pesticides may produce cognitive deficits reflective of hippocampal injury in both humans and rodents. Recent work has indicated that microtubule trafficking is also adversely affected by exposure to the OP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7123a103128d787f7879a383facb67e4
https://doi.org/10.1016/j.neuroscience.2007.01.023
https://doi.org/10.1016/j.neuroscience.2007.01.023
Publikováno v:
Cellular & Molecular Biology Letters
The activity of indoleamine 2, 3-dioxygenase (IDO; E.C. 1.13.11.42) catalyzes the oxidative cleavage of tryptophan to form kynurenine. IDO activity consumes superoxide anions; therefore, we postulated that over-expression of IDO might mitigate supero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf1098dbc1d7d595f8493631eb31e86
http://europepmc.org/articles/PMC6275707
http://europepmc.org/articles/PMC6275707
Autor:
Anilkumar Pillai, Elizabeth J. Hohnadel, Samantha E. Warner, Sahebarao P. Mahadik, Alvin V. Terry, Vinay Parikh, Henry A. Nasrallah, Debra A. Gearhart
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 318:709-724
In this rodent study, we evaluated the effects of different time periods (7, 14, 45, and 90 days) of oral treatment with haloperidol (HAL; 2.0 mg/kg/day) or ziprasidone (ZIP; 12.0 mg/kg/day) on nerve growth factor (NGF) and choline acetyltransferase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8e01a813bbbd243f99dba5cbafb184
https://doi.org/10.1124/jpet.105.099218
https://doi.org/10.1124/jpet.105.099218
Autor:
Debra A. Gearhart, Jennifer L. Waller, S. Warsi, Alvin V. Terry, L.W. Davis, Sahebarao P. Mahadik
Publikováno v:
Neuroscience. 136:519-529
A decrease in alpha7 nicotinic acetylcholine receptors in the hippocampus has been hypothesized to contribute to alterations in auditory gating and other behavioral impairments in schizophrenia. However, while both typical and atypical neuroleptics a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833d4a21c5cf334435ee5adf323f9290
https://doi.org/10.1016/j.neuroscience.2005.08.006
https://doi.org/10.1016/j.neuroscience.2005.08.006
Publikováno v:
Neuroscience Research. 44:255-265
N-Methylated beta-carbolines, including 2-methylnorharman, are structural and functional analogs of the parkinsonian-inducing toxin, MPP+. We are investigating N-methylated beta-carbolines, including 2-methylnorharman, as possible etiologic factors i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51984a8dd5f1ad5d5755cac9f2627fbb
https://doi.org/10.1016/s0168-0102(02)00133-5
https://doi.org/10.1016/s0168-0102(02)00133-5
Publikováno v:
Neurochemistry International. 40:611-620
Mammalian brain has a β-carboline 2 N -methyltransferase activity that converts β-carbolines, such as norharman and harman, into 2 N -methylated β-carbolinium cations, which are structural and functional analogs of the Parkinsonian-inducing toxin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e436fa724778e7c13c1af942c9d490
https://doi.org/10.1016/s0197-0186(01)00115-2
https://doi.org/10.1016/s0197-0186(01)00115-2
Publikováno v:
Neurobiology of Disease, Vol 7, Iss 3, Pp 201-211 (2000)
Enzymatic beta-carboline N-methyltransferase activities generate N-methylated beta-carbolinium cations that are analogs of the parkinsonian-producing neurotoxin MPP+. We measured beta-carboline-2N-methyltransferase and beta-carboline-9N-methyltransfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38acc9e0f94960ccd267ed3477148b7a
https://doi.org/10.1006/nbdi.2000.0287
https://doi.org/10.1006/nbdi.2000.0287