Výsledky vyhledávání - "Debra A. Cheng"

Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis

Autor: Eric Hansen, Lih-Yun Hsu, Debra A. Cheng, Julie Zikherman, Judith F. Ashouri, Marina Sirota, Arthur Weiss, Lisa L. Lattanza, Yiling Chen, Dmitry Rychkov, Steven Yu

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 37

Significance How arthritis-causing T cells trigger rheumatoid arthritis (RA) is not understood since it is difficult to differentiate T cells activated by inflammation in arthritic joints from those activated through their T cell antigen receptor (TC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8b3b92009ae4696c750baabc52dc45
https://doi.org/10.1073/pnas.1904271116

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Atypical presentation of anti-N-methyl-D-aspartate receptor encephalitis in a 61-year-old Hispanic man

Autor: Daa Xiao, Esme Irvine, Debra A. Cheng

Publikováno v: BMJ Case Rep

A 61-year-old Hispanic man with no psychiatric history presented with an acute onset of personality changes, including aggression and hypersexuality, which progressed to hallucinations and fluctuations in mental status, and was diagnosed with anti-N-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af75dc31d4bab87e2ba4bba4f4f9bf59
https://europepmc.org/articles/PMC7733109/

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Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness

Autor: Lih-Yun Hsu, Yiling Chen, Arthur Weiss, Hong-Erh Liang, Debra A. Cheng

Publikováno v: The Journal of experimental medicine, vol 214, iss 3
The Journal of Experimental Medicine

Hsu et al. show that a hypermorphic allele of Zap70, characterized by reduced autoinhibition, is associated with increased TCR signaling and triggers regulatory mechanisms by which negative selection and inhibitory receptors restrain TCR signaling to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc1e914d8a5420e9832c154e7a08c03
https://escholarship.org/uc/item/5x92s2b3

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Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development

Autor: Arthur Weiss, Julie Zikherman, Kevan M. Shokat, Ellen A. Robey, Jenny O. Ross, Debra A. Cheng, Heather J. Melichar, Byron B. Au-Yeung

Publikováno v: Nature immunology

The catalytic activity of Zap70 is crucial for T cell antigen receptor (TCR) signaling, but the quantitative and temporal requirements for its function in thymocyte development are not known. Using a chemical-genetic system to selectively and reversi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632bf07219293e51e51f89fd01f6d073
https://doi.org/10.1038/ni.2918

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The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway

Autor: Arthur R. Salomon, Aaron J. Cantor, Qinqin Ji, Debra A. Cheng, John Kuriyan, Theresa A. Kadlecek, Hanna Sjolin-Goodfellow, Arup K. Chakraborty, Arthur Weiss, Maria P. Frushicheva

Publikováno v: Science signaling, vol 8, iss 377
Sjölin-Goodfellow, H; Frushicheva, MP; Ji, Q; Cheng, DA; Kadlecek, TA; Cantor, AJ; et al.(2015). The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway. Science Signaling, 8(377), ra49. doi: 10.1126/scisignal.2005596. UCSF: Retrieved from: http://www.escholarship.org/uc/item/9rz7n24s
PMC

T cell activation by antigens binding to the T cell receptor (TCR) must be properly regulated to ensure normal T cell development and effective immune responses to pathogens and transformed cells while avoiding autoimmunity. The Src family kinase Lck

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6445e5638c26fe8399c2290a7e56201b
https://escholarship.org/uc/item/9rz7n24s

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A sharp T-cell antigen receptor signaling threshold for T-cell proliferation

Autor: Kevan M. Shokat, James L. Mueller, Yiling Chen, Judith F. Ashouri, Mehrdad Matloubian, Debra A. Cheng, Arthur Weiss, Byron B. Au-Yeung, Julie Zikherman

Publikováno v: Au-Yeung, BB; Zikherman, J; Mueller, JL; Ashouri, JF; Matloubian, M; Cheng, DA; et al.(2014). A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Proceedings of the National Academy of Sciences of the United States of America, 111(35). doi: 10.1073/pnas.1413726111. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1sb1f11z
Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 35

T-cell antigen receptor (TCR) signaling is essential for activation, proliferation, and effector function of T cells. Modulation of both intensity and duration of TCR signaling can regulate these events. However, it remains unclear how individual T c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec24e2f9ad0bbd352592b3b7fc3d4ba
https://europepmc.org/articles/PMC4156735/

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Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation

Autor: Jonathan Chernoff, Olga Pryshchep, Kyle Leonard O'Hagan, Rachelle Kosoff, Marianne Mollenauer, Debra A. Cheng, Stephanie Grace Fairbairn, Arthur Weiss, Hyewon Phee, Maria Radu, Byron B. Au-Yeung

Publikováno v: eLife, Vol 3 (2014)
eLife, vol 3, iss 3
Phee, H; Au-Yeung, BB; Pryshchep, O; O'Hagan, KL; Fairbairn, SG; Radu, M; et al.(2014). Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation. eLife, 2014(3). doi: 10.7554/eLife.02270. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/7p08b232
eLife

The molecular mechanisms that govern thymocyte development and maturation are incompletely understood. The P21-activated kinase 2 (Pak2) is an effector for the Rho family GTPases Rac and Cdc42 that regulate actin cytoskeletal remodeling, but its role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d553632de36f1e967ff718038560311
https://elifesciences.org/articles/02270

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