Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Debra A. Cheng"'
1
Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis
Autor: Eric Hansen, Lih-Yun Hsu, Debra A. Cheng, Julie Zikherman, Judith F. Ashouri, Marina Sirota, Arthur Weiss, Lisa L. Lattanza, Yiling Chen, Dmitry Rychkov, Steven Yu
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 37
Significance How arthritis-causing T cells trigger rheumatoid arthritis (RA) is not understood since it is difficult to differentiate T cells activated by inflammation in arthritic joints from those activated through their T cell antigen receptor (TC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8b3b92009ae4696c750baabc52dc45
https://doi.org/10.1073/pnas.1904271116
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2
Atypical presentation of anti-N-methyl-D-aspartate receptor encephalitis in a 61-year-old Hispanic man
Autor: Daa Xiao, Esme Irvine, Debra A. Cheng
Publikováno v: BMJ Case Rep
A 61-year-old Hispanic man with no psychiatric history presented with an acute onset of personality changes, including aggression and hypersexuality, which progressed to hallucinations and fluctuations in mental status, and was diagnosed with anti-N-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af75dc31d4bab87e2ba4bba4f4f9bf59
https://europepmc.org/articles/PMC7733109/
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3
Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness
Autor: Lih-Yun Hsu, Yiling Chen, Arthur Weiss, Hong-Erh Liang, Debra A. Cheng
Publikováno v: The Journal of experimental medicine, vol 214, iss 3
The Journal of Experimental Medicine
Hsu et al. show that a hypermorphic allele of Zap70, characterized by reduced autoinhibition, is associated with increased TCR signaling and triggers regulatory mechanisms by which negative selection and inhibitory receptors restrain TCR signaling to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc1e914d8a5420e9832c154e7a08c03
https://escholarship.org/uc/item/5x92s2b3
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4
The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway
Autor: Arthur R. Salomon, Aaron J. Cantor, Qinqin Ji, Debra A. Cheng, John Kuriyan, Theresa A. Kadlecek, Hanna Sjolin-Goodfellow, Arup K. Chakraborty, Arthur Weiss, Maria P. Frushicheva
Publikováno v: Science signaling, vol 8, iss 377
Sjölin-Goodfellow, H; Frushicheva, MP; Ji, Q; Cheng, DA; Kadlecek, TA; Cantor, AJ; et al.(2015). The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway. Science Signaling, 8(377), ra49. doi: 10.1126/scisignal.2005596. UCSF: Retrieved from: http://www.escholarship.org/uc/item/9rz7n24s
PMC
T cell activation by antigens binding to the T cell receptor (TCR) must be properly regulated to ensure normal T cell development and effective immune responses to pathogens and transformed cells while avoiding autoimmunity. The Src family kinase Lck
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6445e5638c26fe8399c2290a7e56201b
https://escholarship.org/uc/item/9rz7n24s
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5
A sharp T-cell antigen receptor signaling threshold for T-cell proliferation
Autor: Kevan M. Shokat, James L. Mueller, Yiling Chen, Judith F. Ashouri, Mehrdad Matloubian, Debra A. Cheng, Arthur Weiss, Byron B. Au-Yeung, Julie Zikherman
Publikováno v: Au-Yeung, BB; Zikherman, J; Mueller, JL; Ashouri, JF; Matloubian, M; Cheng, DA; et al.(2014). A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Proceedings of the National Academy of Sciences of the United States of America, 111(35). doi: 10.1073/pnas.1413726111. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1sb1f11z
Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 35
T-cell antigen receptor (TCR) signaling is essential for activation, proliferation, and effector function of T cells. Modulation of both intensity and duration of TCR signaling can regulate these events. However, it remains unclear how individual T c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec24e2f9ad0bbd352592b3b7fc3d4ba
https://europepmc.org/articles/PMC4156735/
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6
Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation
Autor: Jonathan Chernoff, Olga Pryshchep, Kyle Leonard O'Hagan, Rachelle Kosoff, Marianne Mollenauer, Debra A. Cheng, Stephanie Grace Fairbairn, Arthur Weiss, Hyewon Phee, Maria Radu, Byron B. Au-Yeung
Publikováno v: eLife, Vol 3 (2014)
eLife, vol 3, iss 3
Phee, H; Au-Yeung, BB; Pryshchep, O; O'Hagan, KL; Fairbairn, SG; Radu, M; et al.(2014). Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation. eLife, 2014(3). doi: 10.7554/eLife.02270. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/7p08b232
eLife
The molecular mechanisms that govern thymocyte development and maturation are incompletely understood. The P21-activated kinase 2 (Pak2) is an effector for the Rho family GTPases Rac and Cdc42 that regulate actin cytoskeletal remodeling, but its role
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d553632de36f1e967ff718038560311
https://elifesciences.org/articles/02270
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8
A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity
Autor: Chao Zhang, Susan E. Levin, Arthur Weiss, Kevan M. Shokat, Lih-Yun Hsu, Nigel Killeen, Debra A. Cheng, Byron B. Au-Yeung
Publikováno v: Nature immunology
To investigate the role of the kinase Zap70 in T cells, we generated mice expressing a Zap70 mutant whose catalytic activity can be selectively blocked by a small-molecule inhibitor. We found that conventional naive, effector and memory T cells were
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d83a57b61bb89770d938f7deeb664a
https://pubmed.ncbi.nlm.nih.gov/21037577
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