Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Debra A Shearer"'
Monitoring mouse papillomavirus-associated cancer development using longitudinal Pap smear screening
Autor:
Hannah M. Atkins, Aysegul Aksakal Uslu, Jingwei J. Li, Debra A. Shearer, Sarah A. Brendle, Chen Han, Michael Kozak, Paul Lopez, Deesha Nayar, Karla K. Balogh, Catherine Abendroth, Jean Copper, Keith C. Cheng, Neil D. Christensen, Yusheng Zhu, Stefanie Avril, Adam D. Burgener, Thomas T. Murooka, Jiafen Hu
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT A substantial percentage of the population remains at risk for cervical cancer due to pre-existing human papillomavirus (HPV) infections, despite prophylactic vaccines. Early diagnosis and treatment are crucial for better disease outcomes. T
Externí odkaz:
https://doaj.org/article/6e22c5056c51441a99de50ea519d0897
Autor:
Ning Wang, Kristin A Eckert, Ali R Zomorrodi, Ping Xin, Weihua Pan, Debra A Shearer, Judith Weisz, Costas D Maranus, Gary A Clawson
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39446 (2012)
Expression of the serine protease HtrA1 is decreased or abrogated in a variety of human primary cancers, and higher levels of HtrA1 expression are directly related to better response to chemotherapeutics. However, the precise mechanisms leading to Ht
Externí odkaz:
https://doaj.org/article/a9961bde03c94bccb03f60e1ddc45556
Autor:
Nancy M. Cladel, Pengfei Jiang, Jingwei J. Li, Xuwen Peng, Timothy K. Cooper, Vladimir Majerciak, Karla K. Balogh, Thomas J. Meyer, Sarah A. Brendle, Lynn R. Budgeon, Debra A. Shearer, Regina Munden, Maggie Cam, Raghavan Vallur, Neil D. Christensen, Zhi-Ming Zheng, Jiafen Hu
Publikováno v:
Emerging Microbes and Infections, Vol 8, Iss 1, Pp 1108-1121 (2019)
ABSTRACTHuman papillomaviruses (HPV) contribute to most cervical cancers and are considered to be sexually transmitted. However, papillomaviruses are often found in cancers of internal organs, including the stomach, raising the question as to how the
Externí odkaz:
https://doaj.org/article/14b4fcbaf652421bacab4a29543817a2
Autor:
Jiafen Hu, Sarah A. Brendle, Jingwei J. Li, Vonn Walter, Nancy M. Cladel, Timothy Cooper, Debra A. Shearer, Karla K. Balogh, Neil D. Christensen
Publikováno v:
Viruses, Vol 14, Iss 5, p 980 (2022)
Contraceptives such as Depo-medroxyprogesterone (DMPA) are used by an estimated 34 million women worldwide. DMPA has been associated with increased risk of several viral infections including Herpes simplex virus-2 (HSV-2) and Human immunodeficiency v
Externí odkaz:
https://doaj.org/article/c8a4a3ac337d434eb03821a6a0c4b453
Autor:
Sarah Brendle, Jingwei J. Li, Nancy M. Cladel, Debra A. Shearer, Lynn R. Budgeon, Karla K. Balogh, Hannah Atkins, Marina Costa-Fujishima, Paul Lopez, Neil D. Christensen, John Doorbar, Thomas T. Murooka, Jiafen Hu
Publikováno v:
Viruses, Vol 13, Iss 9, p 1824 (2021)
Papillomavirus L1 and L2, the major and minor capsid proteins, play significant roles in viral assembly, entry, and propagation. In the current study, we investigate the impact of L1 and L2 on viral life cycle and tumor growth with a newly establishe
Externí odkaz:
https://doaj.org/article/1a3b57b1851d435f82214a82c7040daf
Autor:
Sarah A. Brendle, Jingwei Li, Nancy M. Cladel, Karla K. Balogh, Jennifer Booth, Debra A. Shearer, Vonn Walter, Song Lu, Neil D. Christensen, Danielle Covington, Jake DeBroff, Janice Milici, Yusheng Zhu, Raphael Viscidi, Jiafen Hu
Publikováno v:
J Virol
We have established a mouse papillomavirus (MmuPV1) model that induces both cutaneous and mucosal infections and cancers. In the current study, we use this model to test our hypothesis that passive immunization using a single neutralizing monoclonal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d635fb648406bfe59b7af716c9dbbf77
https://europepmc.org/articles/PMC9400481/
https://europepmc.org/articles/PMC9400481/
Autor:
Marina Costa-Fujishima, Karla K. Balogh, Lynn R. Budgeon, Hannah Atkins, Paul Lopez, Debra A. Shearer, Neil D. Christensen, Nancy M. Cladel, John Doorbar, Sarah A. Brendle, Jingwei J. Li, Jiafen Hu, Thomas T. Murooka
Publikováno v:
Viruses
Viruses, Vol 13, Iss 1824, p 1824 (2021)
Volume 13
Issue 9
Viruses, Vol 13, Iss 1824, p 1824 (2021)
Volume 13
Issue 9
Papillomavirus L1 and L2, the major and minor capsid proteins, play significant roles in viral assembly, entry, and propagation. In the current study, we investigate the impact of L1 and L2 on viral life cycle and tumor growth with a newly establishe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767e24dc65e4497735ce39cdf6d860ba
https://pubmed.ncbi.nlm.nih.gov/34578405
https://pubmed.ncbi.nlm.nih.gov/34578405
Autor:
Judith Weisz, David S. Phelps, Vernon M. Chinchilli, Joanna Floros, Xuesheng Zhang, Lili Yang, Debra A. Shearer
Publikováno v:
JCI Insight, Vol 5, Iss 24 (2020)
JCI Insight
JCI Insight
Alveolar macrophages (AMs) are differentially regulated by human surfactant protein-A1 (SP-A1) or SP-A2. However, AMs are very heterogeneous and differences are difficult to characterize in intact cells. Using the Toponome Imaging System (TIS), an im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9decfc53c0e183f7075bb1610a6e11
https://doaj.org/article/05278761296545e2b9272819245cbac5
https://doaj.org/article/05278761296545e2b9272819245cbac5
Autor:
Andrea J Osborne, Sarah A. Brendle, Jiafen Hu, Debra A. Shearer, Karla K. Balogh, Clare E. Sample, Neil D. Christensen, Hannah M Atkins
Publikováno v:
Comp Med
Epstein-Barr Virus (EBV) is a γ-herpesvirus which infects over 90% of the adult human population. Most notably, this virus causes infectious mononucleosis but it is also associated with cancers such as Hodgkin and Burkitt lymphoma. EBV is a species-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374a9ed61a5e522ffba72715e07a7e2b
https://europepmc.org/articles/PMC7574219/
https://europepmc.org/articles/PMC7574219/
Autor:
Karam El-Bayoumy, Raphael P. Viscidi, Jingwei Li, Krishne Gowda, Neil D. Christensen, Hannah M Atkins, Cesar Aliaga, Sarah A. Brendle, Debra A. Shearer, Kun Ming Chen, Jiafen Hu, Vonn Walter, Karla K. Balogh, Yuan Wan Sun, Shantu Amin, Douglas B. Stairs
Publikováno v:
Chem Biol Interact
HPV infections in the oral cavity that progress to cancer are on the increase in the USA. Model systems to study co-factors for progression of these infections are lacking as HPVs are species-restricted and cannot grow in preclinical animal models. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308fa6fdc9bf4fc60a13e95174a7d644
https://pubmed.ncbi.nlm.nih.gov/33186600
https://pubmed.ncbi.nlm.nih.gov/33186600