Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Debra A, Cockayne"'
Autor:
Debra A Cockayne, Donavan T Cheng, Benjamin Waschki, Sriram Sridhar, Palanikumar Ravindran, Holly Hilton, Galina Kourteva, Hans Bitter, Sreekumar G Pillai, Sudha Visvanathan, Kai-Christian Müller, Olaf Holz, Helgo Magnussen, Henrik Watz, Jay S Fine
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38629 (2012)
The identification and validation of biomarkers to support the assessment of novel therapeutics for COPD continues to be an important area of research. The aim of the current study was to identify systemic protein biomarkers correlated with measures
Externí odkaz:
https://doaj.org/article/d670836d162341129c02f54fff4b294d
Autor:
Szabolcs Deladi, Debra A. Cockayne, Erik Godefridus Antonius Harks, David E. Haines, Matthew Wright, Rob Brink, Joseph Cefalu, Darrell L. Rankin, Harm Jan Willem Belt, William Stoffregen, Alexander F. Kolen, Steven Antonie Willem Fokkenrood
Publikováno v:
Wright, M, Harks, E, Deladi, S, Fokkenrood, S, Brink, R, Belt, H, Kolen, A F, Rankin, D, Stoffregen, W, Cockayne, D A, Cefalu, J & Haines, D E 2018, ' Characteristics of Radiofrequency Catheter Ablation Lesion Formation in Real Time In Vivo Using Near Field Ultrasound Imaging ', JACC: Clinical Electrophysiology . https://doi.org/10.1016/j.jacep.2018.04.002
Objectives Visualizing myocardium with near field ultrasound (NFUS) transducers in the tip of the catheter might provide an image of the evolving pathological lesion during energy delivery. BackgroundRadiofrequency (RF) catheter ablation has been eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9d976271db919398e0d96b8f3e0fc8
https://doi.org/10.1016/j.jacep.2018.04.002
https://doi.org/10.1016/j.jacep.2018.04.002
Autor:
Allen F. Ryan, Gary D. Housley, Debra A. Cockayne, Srdjan M. Vlajkovic, Rachel T. Morton-Jones, Peter R. Thorne
Publikováno v:
Purinergic Signalling, vol 11, iss 4
In the cochlea, Reissner's membrane separates the scala media endolymphatic compartment that sustains the positive endocochlear potential and ion composition necessary for sound transduction, from the scala vestibuli perilymphatic compartment. It is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda44300533958a6bf441a350c215e03
https://doi.org/10.1007/s11302-015-9473-4
https://doi.org/10.1007/s11302-015-9473-4
Autor:
Donavan T, Cheng, Deog Kyeom, Kim, Debra A, Cockayne, Anton, Belousov, Hans, Bitter, Michael H, Cho, Annelyse, Duvoix, Lisa D, Edwards, David A, Lomas, Bruce E, Miller, Niki, Reynaert, Ruth, Tal-Singer, Emiel F M, Wouters, Alvar, Agustí, Leonardo M, Fabbri, Alex, Rames, Sudha, Visvanathan, Stephen I, Rennard, Paul, Jones, Harsukh, Parmar, William, MacNee, Gerhard, Wolff, Edwin K, Silverman, Ruth J, Mayer, Sreekumar G, Pillai, Stephen, Rennard
Publikováno v:
American Journal of Respiratory and Critical Care Medicine, 188(8), 948-957. American Thoracic Society
Emphysema in chronic obstructive pulmonary disease (COPD) can be characterized by high-resolution chest computed tomography (HRCT); however, the repeated use of HRCT is limited because of concerns regarding radiation exposure and cost.To evaluate bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f375ce5b7dd71f7b4df45f363e1568e
https://cris.maastrichtuniversity.nl/en/publications/6a0ff943-6ca2-4a9a-a6e9-f5882682b0d0
https://cris.maastrichtuniversity.nl/en/publications/6a0ff943-6ca2-4a9a-a6e9-f5882682b0d0
Autor:
Timothy K. Y. Kaan, Philip A. Nunn, Yu Zhong, Meirion Davies, Anthony H. Dickenson, Debra A. Cockayne, Sital Patel, Fabien Marchand, Ping K. Yip, Stephen B. McMahon, Marzia Malcangio, Anthony P.D.W. Ford
Publikováno v:
Brain. 133:2549-2564
Pain remains an area of considerable unmet clinical need, and this is particularly true of pain associated with bone metastases, in part because existing analgesic drugs show only limited efficacy in many patients and in part because of the adverse s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb157748e20f56486240c130b8c8afb
https://doi.org/10.1093/brain/awq194
https://doi.org/10.1093/brain/awq194
Autor:
Charles Alois Dvorak, Francisco Javier Lopez-Tapia, Xiaojun Huang, Brad Loe, Debra A. Cockayne, William L. Fitch, Scott Broadbent, Berger Jacob, Christine E. Brotherton-Pleiss, Keith A. M. Walker, Rebecca Suttmann, David L. Bourdet, Lee Edwin Lowrie, Shelley K. Gleason, Dov Nitzan, Paul J. Wagner, Jiang Zhu, Zhao Shu-Hai, Fernando Padilla, André Alker, Joanie Caroon, Deborah Phippard, Alam Jahangir, Pankaj D. Rege
Publikováno v:
Journal of medicinal chemistry. 58(21)
Identification of singleton P2X7 inhibitor 1 from HTS gave a pharmacophore that eventually turned into potential clinical candidates 17 and 19. During development, a number of issues were successfully addressed, such as metabolic stability, plasma st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e880f027ef8eadeaef6f8cc77b4f99c
https://pubmed.ncbi.nlm.nih.gov/26460788
https://pubmed.ncbi.nlm.nih.gov/26460788
Autor:
Joel R Gever, Michael Patrick Dillon, Geoffrey Burnstock, Anthony P.D.W. Ford, Debra A. Cockayne
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 452:513-537
Significant progress in understanding the pharmacological characteristics and physiological importance of homomeric and heteromeric P2X channels has been achieved in recent years. P2X channels, gated by ATP and most likely trimerically assembled from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a06d2017e4da9b77609bc4215d79921
https://doi.org/10.1007/s00424-006-0070-9
https://doi.org/10.1007/s00424-006-0070-9
Autor:
Philip A. Nunn, Anthony P.D.W. Ford, Michael Patrick Dillon, Joseph S. Cefalu, Joel R Gever, Yu Zhong, Debra A. Cockayne
Publikováno v:
British Journal of Pharmacology. 147:S132-S143
Lower urinary tract symptoms (LUTS) are present in many common urological syndromes. However, their current suboptimal management by muscarinic and α1-adrenoceptor antagonists leaves a significant opportunity for the discovery and development of sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8610849e3f4b6dedfc831effc66384d
https://doi.org/10.1038/sj.bjp.0706637
https://doi.org/10.1038/sj.bjp.0706637
Autor:
Jey-Myung Lee, Stacey Barrick, Lori A. Birder, Elena M. Balestreire, Wily G. Ruiz, Debra A. Cockayne, Edward Wang, Gerard Apodaca, Maximilian von Bodungen
Publikováno v:
Journal of Clinical Investigation. 115:2412-2422
The umbrella cells that line the bladder are mechanosensitive, and bladder filling increases the apical surface area of these cells; however, the upstream signals that regulate this process are unknown. Increased pressure stimulated ATP release from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24dac2d635740e837da6692aac2dfafb
https://doi.org/10.1172/jci24086
https://doi.org/10.1172/jci24086
Autor:
Yun Guan, Debra A. Cockayne, Michael J. Caterina, Srinivasa N. Raja, Michael F. Jarvis, Chengshui Zhao, Tohko Iida, Isao Shimizu
Publikováno v:
Pain. 116:96-108
P2X3 is an ATP-gated cation channel subtype expressed by a subpopulation of primary sensory neurons. In vivo spinal cord recordings in mice lacking P2X3 ( P 2 X 3 − / − ) have suggested that this protein may be important for the coding of periphe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940d7f08e9de1abe5a001078633319ae
https://doi.org/10.1016/j.pain.2005.03.030
https://doi.org/10.1016/j.pain.2005.03.030