Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Debra, Dunlap"'
Autor:
Jennifer Cantley, Xiaofen Ye, Emma Rousseau, Tom Januario, Brian D. Hamman, Christopher M. Rose, Tommy K. Cheung, Trent Hinkle, Leofal Soto, Connor Quinn, Alicia Harbin, Elizabeth Bortolon, Xin Chen, Roy Haskell, Eva Lin, Shang-Fan Yu, Geoff Del Rosario, Emily Chan, Debra Dunlap, Hartmut Koeppen, Scott Martin, Mark Merchant, Matt Grimmer, Fabio Broccatelli, Jing Wang, Jennifer Pizzano, Peter S. Dragovich, Michael Berlin, Robert L. Yauch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
SMARCA2 has been identified as a synthetic lethal target in SMARCA4 mutated tumors, however, homology between the two has hindered the development of selective SMARCA2 inhibitors. Here, the authors synthesize a proteolysis targeting chimera (PROTAC)
Externí odkaz:
https://doaj.org/article/8a0e9dc628914f238a2a801adba2571a
Autor:
Arna Katewa, Eric Suto, Jessica Hui, Jose Heredia, Jie Liang, Jason Hackney, Keith Anderson, Tuija M Alcantar, Natasha Bacarro, Debra Dunlap, Jeffrey Eastham, Andres Paler-Martinez, Xin Y Rairdan, Zora Modrusan, Wyne P Lee, Cary D Austin, Daniel Lafkas, Nico Ghilardi
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0244439 (2021)
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease representing a serious unmet medical need. The disease is associated with the loss of self-tolerance and exaggerated B cell activation, resulting in autoantibody production and the fo
Externí odkaz:
https://doaj.org/article/ed0d04cf471f47d69accfbf3ee12f167
Autor:
Akshay T. Krishnamurty, Justin A. Shyer, Minh Thai, Vineela Gandham, Matthew B. Buechler, Yeqing Angela Yang, Rachana N. Pradhan, Amber W. Wang, Patricia L. Sanchez, Yan Qu, Beatrice Breart, Cécile Chalouni, Debra Dunlap, James Ziai, Justin Elstrott, Neelie Zacharias, Weiguang Mao, Rebecca K. Rowntree, Jack Sadowsky, Gail D. Lewis, Thomas H. Pillow, Barzin Y. Nabet, Romain Banchereau, Lucinda Tam, Roger Caothien, Natasha Bacarro, Merone Roose-Girma, Zora Modrusan, Sanjeev Mariathasan, Sören Müller, Shannon J. Turley
Publikováno v:
Nature. 611:148-154
Recent single-cell studies of cancer in both mice and humans have identified the emergence of a myofibroblast population specifically marked by the highly restricted leucine-rich-repeat-containing protein 15 (LRRC15)1–3. However, the molecular sign
Autor:
Ben Korin, Shimrit Avraham, Reuben Moncada, Terence Ho, Mayra Cruz Tleugabulova, Hari Menon, Spyros Darmanis, Yuxin Liang, Zora Modrusan, Cecile Chalouni, Charles Victoria, Linda Rangell, Charles Havnar, Will Ewart, Charles Jones, Jian Jiang, Debra Dunlap, Monika Dohse, Andrew McKay, Joshua D Webster, Steffen Durinck, Andrey S Shaw
The kidney is a complex organ that governs many physiological parameters. It is roughly divided into three parts, the renal pelvis, medulla, and cortex. Covering the cortex is the renal capsule, a serosal tissue that provides protection and forms a b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::814df12cc71dbee0413511301194ee45
https://doi.org/10.1101/2023.05.11.540033
https://doi.org/10.1101/2023.05.11.540033
Autor:
Teemu T. Junttila, Yan Wu, Jian Payandeh, C. Andrew Boswell, Genee Lee, Klara Totpal, James Ziai, Diego Ellerman, Dionysos Slaga, Elaine Mai, Daniel Bravo-Perez, Meric Ovacik, Hao Cai, Thinh Pham, Debra Dunlap, Kathy Hötzel, Wei-Ching Liang, Dorothee Nickles, Robyn Clark, Maria Hristopoulos, Danielle Mandikian, Ji Li, Jennifer Johnston, Amy A. Lo
Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04daf2ea0517ac17fcc1c07f5890422c
https://doi.org/10.1158/1535-7163.22522546
https://doi.org/10.1158/1535-7163.22522546
Autor:
Teemu T. Junttila, Yan Wu, Jian Payandeh, C. Andrew Boswell, Genee Lee, Klara Totpal, James Ziai, Diego Ellerman, Dionysos Slaga, Elaine Mai, Daniel Bravo-Perez, Meric Ovacik, Hao Cai, Thinh Pham, Debra Dunlap, Kathy Hötzel, Wei-Ching Liang, Dorothee Nickles, Robyn Clark, Maria Hristopoulos, Danielle Mandikian, Ji Li, Jennifer Johnston, Amy A. Lo
Ovarian cancer is a diverse class of tumors with very few effective treatment options and suboptimal response rates in early clinical studies using immunotherapies. Here we describe LY6/PLAUR domain containing 1 (LYPD1) as a novel target for therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05eedefc11b81d2abce20352199842ec
https://doi.org/10.1158/1535-7163.c.6543427
https://doi.org/10.1158/1535-7163.c.6543427
Autor:
Ganapati V Hegde, Cecile de la Cruz, Jennifer M Giltnane, Lisa Crocker, Avinashnarayan Venkatanarayan, Gabriele Schaefer, Debra Dunlap, Joerg D Hoeck, Robert Piskol, Florian Gnad, Zora Modrusan, Frederic J de Sauvage, Christian W Siebel, Erica L Jackson
Publikováno v:
eLife, Vol 8 (2019)
Squamous cell carcinomas (SCCs) account for the majority of cancer mortalities. Although TP63 is an established lineage-survival oncogene in SCCs, therapeutic strategies have not been developed to target TP63 or it’s downstream effectors. In this s
Externí odkaz:
https://doaj.org/article/6f4e75535ef4450d90e11913cada4356
Fibroblast growth factors (FGF) play important roles in development, angiogenesis, and cancer. FGF19 uniquely binds to FGF receptor 4 (FGFR4). Our previous study has shown that FGF19 transgenic tumors have an activated Wnt-pathway phenotype. Wnt sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8473f1014c4ac22d4faa02cc68f258c
https://doi.org/10.1158/0008-5472.c.6497124
https://doi.org/10.1158/0008-5472.c.6497124
Supplementary Table 1 from Inhibition of Fibroblast Growth Factor 19 Reduces Tumor Growth by Modulating β-Catenin Signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255be2f0f463f10d61befcdb48a916da
https://doi.org/10.1158/0008-5472.22373535
https://doi.org/10.1158/0008-5472.22373535
Supplementary Figure 1-8 from Inhibition of Fibroblast Growth Factor 19 Reduces Tumor Growth by Modulating β-Catenin Signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2feb2dcee025f2b26a08de24316046e9
https://doi.org/10.1158/0008-5472.22373538
https://doi.org/10.1158/0008-5472.22373538