Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Deborah Y. Kwon"'
Autor:
Dilara O. Halim, Gopinath Krishnan, Evan P. Hass, Soojin Lee, Mamta Verma, Sandra Almeida, Yuanzheng Gu, Deborah Y. Kwon, Thomas G. Fazzio, Fen-Biao Gao
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114375- (2024)
Summary: GGGGCC (G4C2) repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). How this genetic mutation leads to neurodegeneration remains largely unknown. Using CRISPR-C
Externí odkaz:
https://doaj.org/article/db2eea12f92c422ea5615950ffbf79b1
Autor:
Deborah Y. Kwon, Bing Xu, Peng Hu, Ying-Tao Zhao, Jonathan A. Beagan, Jonathan H. Nofziger, Yue Cui, Jennifer E. Phillips-Cremins, Julie A. Blendy, Hao Wu, Zhaolan Zhou
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The mechanisms underlying the chronic stress-induced increased risk for major depressive disorder and anxiety are unclear. Here, the authors show the transcriptional changes occurring in neocortical neurons and identify YY1 as a regulator of chronic
Externí odkaz:
https://doaj.org/article/a4ebaaa7bd0e4a8ca9b257ee066c81e7
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
CRISPR-Cas9 has been utilized, through the fusion of catalytic dead nuclease with chromatin-remodellers, to modify the epigenetic state of specific loci. Here the authors manipulate locus-specific histone acetylation and describe the parameters that
Externí odkaz:
https://doaj.org/article/68674fac55494938b72e23f926e02371
Autor:
Emily Foran, Deborah Y. Kwon, Jonathan H. Nofziger, Eveline S. Arnold, Matthew D. Hall, Kenneth H. Fischbeck, Barrington G. Burnett
Publikováno v:
Neurobiology of Disease, Vol 88, Iss , Pp 118-124 (2016)
The development of therapeutics for neurological disorders is constrained by limited access to the central nervous system (CNS). ATP-binding cassette (ABC) transporters, particularly P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP),
Externí odkaz:
https://doaj.org/article/891d7a1cee84474a87764f91c4d60f2e
Autor:
Yoshifumi Sonobe, Soojin Lee, Gopinath Krishnan, Yuanzheng Gu, Deborah Y. Kwon, Fen-Biao Gao, Raymond P. Roos, Paschalis Kratsios
A hexanucleotide repeat expansion in the first intron of C9ORF72 is the most common monogenic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A hallmark of ALS/FTD pathology is the presence of dipeptide repeat (DPR) pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e3f1f0135b761a1807c4ea922aa5822
https://doi.org/10.1101/2022.08.06.503063
https://doi.org/10.1101/2022.08.06.503063
Autor:
Ying-Tao Zhao, Julie A. Blendy, Yue Cui, Hao Wu, Bing Xu, Jonathan A. Beagan, Jonathan H. Nofziger, Deborah Y. Kwon, Peng Hu, Zhaolan Zhou, Daria Zaitseva, Jennifer E. Phillips-Cremins
Prolonged stress exposure is a major risk factor for the development of depression and comorbid anxiety. Efforts to understand how recurrent stress induces behavioral maladaptation have largely concentrated on the neuronal synapse with limited unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44eb4b1173c27e365d4078bf9ff61e1f
https://doi.org/10.1101/2020.07.06.190280
https://doi.org/10.1101/2020.07.06.190280
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30437 (2012)
P-element vectors are commonly used to make transgenic Drosophila and generally insert in the genome in a nonselective manner. However, when specific fragments of regulatory DNA from a few Drosophila genes are incorporated into P-transposons, they ca
Externí odkaz:
https://doaj.org/article/3fdc49d8bdb54bdf950b664a24466efa
Autor:
Jonathan H. Nofziger, Barrington G. Burnett, Emily Foran, Eveline S. Arnold, Matthew D. Hall, Deborah Y. Kwon, Kenneth H. Fischbeck
Publikováno v:
Neurobiology of Disease, Vol 88, Iss, Pp 118-124 (2016)
The development of therapeutics for neurological disorders is constrained by limited access to the central nervous system (CNS). ATP-binding cassette (ABC) transporters, particularly P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c538a5911348b95dc73227dd68558656
https://doi.org/10.1016/j.nbd.2016.01.008
https://doi.org/10.1016/j.nbd.2016.01.008
Autor:
Tae Hoon Kim, Golnaz Vahedi, Brian S. Johnson, Ying-Tao Zhao, Chuan He, Maria Fasolino, Deborah Y. Kwon, Janine M. Lamonica, Zhaolan Zhou, Yoon Jung Kim, Boxuan Simen Zhao
Publikováno v:
Genome research. 28(7)
Genetic variants associated with autism spectrum disorders (ASDs) are enriched in genes encoding synaptic proteins and chromatin regulators. Although the role of synaptic proteins in ASDs is widely studied, the mechanism by which chromatin regulators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c500d784e81014012d9ad69c97c9b96e
https://pubmed.ncbi.nlm.nih.gov/29848492
https://pubmed.ncbi.nlm.nih.gov/29848492
Summary Massively parallel single-cell RNA sequencing can precisely resolve cellular diversity in a high-throughput manner at low cost, but unbiased isolation of intact single cells from complex tissues such as adult mammalian brains is challenging.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3272a6f4ec5c6af17a2ff2773b7bea93
https://europepmc.org/articles/PMC5743496/
https://europepmc.org/articles/PMC5743496/