Generation and characterization of anti-AA amyloid-specific monoclonal antibodies

Autor: Jonathan S Wall, Stephen J Kennel, Tina eRichey, Amy eAllen, Alan eStuckey, Deborah T Weiss, Sallie D Macy, Robin eBarbour, Peter eSeubert, Alan eSolomon, Dale eSchenk

Publikováno v: Frontiers in Immunology, Vol 2 (2011)

AA amyloidosis results from the pathologic deposition in the kidneys and other organs of fibrils composed of N-terminal fragments of serum amyloid A protein (SAA). Given that there are only limited means to visualize these deposits, we have developed

Externí odkaz: https://doaj.org/article/7cfe2d04166f4f87bcc8dde5821b273f

Recombinant HIV-1 vaccine candidates based on replication-defective flavivirus vector

Autor: B. H. Oakes, Thierry Calandra, Chelsey Bennett, Kathryn E. Foulds, Ralf Wagner, Matthieu Perreau, Mark Parrington, Annette Ives, J. McElrath, Konstantin V. Pugachev, Bertram L. Jacobs, Thierry Roger, Georgia D. Tomaras, Mariano Esteban, Guido Ferrari, Nicole L. Yates, David C. Montefiori, Harold Kleanthous, Mario Roederer, Bryan T. Mayer, Karen V. Kibler, Giuseppe Pantaleo, S. Ding, M. Vaine, Sanjay Phogat, Benedikt Asbach, Beatriz Perdiguero, Shing Fen Kao, Deborah T. Weiss, A. G. Spies, Gregory J. Mize, Jim Tartaglia, Raphael Gottardo, Maryann Giel-Moloney

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Scientific reports, vol. 9, no. 1, pp. 20005
Scientific Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname

Multiple approaches utilizing viral and DNA vectors have shown promise in the development of an effective vaccine against HIV. In this study, an alternative replication-defective flavivirus vector, RepliVax (RV), was evaluated for the delivery of HIV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c440ba3a669e2a4c5a0e11f58f180f82
http://hdl.handle.net/10261/241086

Novel Strategy To Adapt Simian-Human Immunodeficiency Virus E1 Carrying env from an RV144 Volunteer to Rhesus Macaques: Coreceptor Switch and Final Recovery of a Pathogenic Virus with Exclusive R5 Tropism

Autor: Jennifer Delgado, Sharon Orndorff, Amanda Strickland, Celia C. LaBranche, Maria Grazia Ferrari, Deborah T. Weiss, Punnee Pitisuttithum, Sorachai Nitayaphan, Jim Treece, Hemant K. Vyas, Agnès Laurence Chenine, Anthony Griffiths, Robert McLinden, Ruth M. Ruprecht, Hanna B. Scinto, Supachai Rerks-Ngarm, Sandeep Gupta, Merlin L. Robb, Siddappa N. Byrareddy, Swati Thorat, Ranajit Pal, Jerome H. Kim, Muhammad M. Mukhtar, Elizabeth Plake, Nelson L. Michael, David C. Montefiori

Publikováno v: Journal of Virology. 92

The phase III RV144 human immunodeficiency virus (HIV) vaccine trial conducted in Thailand remains the only study to show efficacy in decreasing the HIV acquisition risk. In Thailand, circulating recombinant forms of HIV clade A/E (CRF01_AE) predomin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9516bd609a9d638c2c55c9e4c1bd370
https://doi.org/10.1128/jvi.02222-17

Superiority in Rhesus Macaques of Targeting HIV-1 Env gp140 to CD40 versus LOX-1 in Combination with Replication-Competent NYVAC-KC for Induction of Env-Specific Antibody and T Cell Responses

Autor: Steve Self, Raphael Gottardo, Nicole L. Yates, Andres M. Salazar, Guido Ferrari, Yves Levy, Mario Roederer, Bertram L. Jacobs, Sandra Zurawski, Xuesong Yu, Gerard Zurawski, Christine Lacabaratz, Peter Klucar, Shing Fen Kao, Georgia D. Tomaras, Giuseppe Pantaleo, Celia C. LaBranche, Karen V. Kibler, Anthony D. Cristillo, Lindsey Galmin, William Fulp, Deborah T. Weiss, Sherry Stanfield-Oakley, Kathryn E. Foulds, Xiaoying Shen, David C. Montefiori, Zhiqing Wang, Alicia Sato

Publikováno v: Journal of Virology. 91

We compared the HIV-1-specific immune responses generated by targeting HIV-1 envelope protein (Env gp140) to either CD40 or LOX-1, two endocytic receptors on dendritic cells (DCs), in rhesus macaques primed with a poxvirus vector (NYVAC-KC) expressin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ecce758d8dcf28c799dda2a51011b93
https://doi.org/10.1128/jvi.01596-16

An HIV gp120-CD4 Immunogen Does Not Elicit Autoimmune Antibody Responses in Cynomolgus Macaques

Autor: Anthony L. DeVico, Jennifer Schwartz, Johnathan Misamore, Ilia Prado, Deborah T. Weiss, Timothy R. Fouts, George K. Lewis, Anthony D. Cristillo, Robert C. Gallo, Maria Cecilia Huaman, Jesse Francis, Ranajit Pal

Publikováno v: Clinical and vaccine immunology : CVI. 23(7)

A promising concept for human immunodeficiency virus (HIV) vaccines focuses immunity on the highly conserved transition state structures and epitopes that appear when the HIV glycoprotein gp120 binds to its receptor, CD4. We are developing chimeric a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9b10f95054ce5f4f606f3745d029bb
https://pubmed.ncbi.nlm.nih.gov/27193040