Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Deborah Stuart"'
Publikováno v:
Physiological Reports, Vol 10, Iss 5, Pp n/a-n/a (2022)
Abstract Loss of nephron primary cilia due to disruption of the Ift88 gene results in sex‐ and age‐specific phenotypes involving renal cystogenesis, blood pressure (BP) and urinary Na+ excretion. Previous studies demonstrated that male mice under
Externí odkaz:
https://doaj.org/article/aed50ae43f554bd4895dbdff4305e005
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 14 (2018)
Background In vitro studies suggest that nephron nitric oxide synthase 3 (NOS3) modulates tubule Na+ transport. Methods and Results To assess nephron NOS3 relevance in vivo, knockout (KO) mice with doxycycline‐inducible nephron‐wide deletion of N
Externí odkaz:
https://doaj.org/article/e76d9d41a3644f04bb23e722ababed42
Autor:
Kai Song, Deborah Stuart, Nikita Abraham, Fei Wang, Shuping Wang, Tianxin Yang, Curt D Sigmund, Donald E Kohan, Nirupama Ramkumar
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159872 (2016)
Collecting duct (CD)-derived renin is involved in the hypertensive response to chronic angiotensin-II (Ang-II) administration. However, whether CD renin is involved in Ang-II independent hypertension is currently unknown. To begin to examine this, 12
Externí odkaz:
https://doaj.org/article/9f99f98c5df04f83bd498281073c64d7
Publikováno v:
Physiology. 38
Background: Cleavage of the extra-cellular domain of the (pro)renin receptor (PRR) yields a soluble fragment (sPRR), that has been implicated in the pathogenesis of hypertension. We recently developed a novel mouse model with mutation in the cleavage
Autor:
Grant Russell, Susannah Westbury, Sharon Clifford, Elizabeth Sturgiss, Anna Fragkoudi, Rob Macindoe, Deborah Stuart, Marina Kunin, Jill Walsh, Cathie Scott
Publikováno v:
Australian Journal of Primary Health. 28:143-150
Access to appropriate health and social care is challenging for vulnerable populations. We used a ‘pop-up’ delivery model to bring community-based services in contact with communities with poor access to health and social care. Our aim was to exa
Autor:
Masaaki Yoshigi, Deborah Stuart, Kennedy Koehler, Harini Srinivasan, Douglas C Eaton, Nirupama Ramkumar, Brandi M Wynne
Publikováno v:
Hypertension. 79
Hypertension (HTN) is associated with an increase in pro-inflammatory cytokines. Sentinel renal dendritic cells (rDCs) form an intricate network within the kidney cortex. DCs can activate immune cells and secrete pro-inflammatory cytokines. We hypoth
Autor:
Deborah Stuart, Caitlin S. Peterson, Chunyan Hu, Monica P. Revelo, Yufeng Huang, Donald E. Kohan, Nirupama Ramkumar
Publikováno v:
Canadian journal of physiology and pharmacology. 100(8)
Two recent clinical trials, using sodium glucose cotransporter (SGLT2) or endothelin-A receptor (ET-A) blocker, reported the first efficacious treatments in 18 years to slow progression of diabetic kidney disease (DKD). We hypothesized that combined
Publikováno v:
The FASEB Journal. 35
Autor:
William Wheatley, J. David Symons, Caitlin S. Peterson, Jae Min Cho, Donald E. Kohan, Chunyan Hu, Deborah Stuart, Nirupama Ramkumar
Publikováno v:
Circ Res
Rationale: Cleavage of the extracellular domain of the PRR ([pro]renin receptor) yields a soluble fragment (sPRR). Although changes in plasma sPRR levels have been reported in hypertension, the causal role of sPRR in blood pressure regulation is unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::718b8ed16fc5a3f9129bd4b472bcd0b9
https://europepmc.org/articles/PMC8225587/
https://europepmc.org/articles/PMC8225587/
Autor:
Donald E. Kohan, James D. Stockand, Deborah Stuart, Jayalakshmi Lakshmipathi, Nirupama Ramkumar, Nikita Abraham, Yang Gao, Elena Mironova, Shuping Wang
Publikováno v:
American Journal of Physiology-Renal Physiology. 315:F607-F617
The collecting duct is the predominant nephron site of prorenin and prorenin receptor (PRR) expression. We previously demonstrated that the collecting duct PRR regulates epithelial Na+ channel (ENaC) activity and water transport; however, which cell