Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Deborah Silvera"'
Autor:
Viviana Volta, Robert J. Schneider, Jinhua Wang, Deborah Silvera, Rezina Arju, Eileen P. Connolly, Amanda Ernlund
Publikováno v:
Molecular and Cellular Biology. 37
mTOR coordinates growth signals with metabolic pathways and protein synthesis and is hyperactivated in many human cancers. mTOR exists in two complexes: mTORC1, which stimulates protein, lipid, and ribosome biosynthesis, and mTORC2, which regulates c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc03204ac7c68535ac69051b99039b08
https://doi.org/10.1128/mcb.00577-16
https://doi.org/10.1128/mcb.00577-16
Autor:
Deborah Silvera, Ilana Belitskaya-Levy, Silvia C. Formenti, Alan A. Arslan, Shah Giashuddin, Robert J. Schneider, Rezina Arju
Publikováno v:
Breast Cancer Research and Treatment. 134:981-988
Locally advanced breast cancer (LABC) was initially characterized as a large primary tumor (≥5 cm), associated with or without skin or chest-wall involvement, fixed axillary lymph nodes, or disease spread to the ipsilateral internal mammary or supr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4300822c7cdf7403768a1864a4064467
https://doi.org/10.1007/s10549-012-2017-5
https://doi.org/10.1007/s10549-012-2017-5
Publikováno v:
Nature Reviews Cancer. 10:254-266
Remarkable progress has been made in defining a new understanding of the role of mRNA translation and protein synthesis in human cancer. Translational control is a crucial component of cancer development and progression, directing both global control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09957bc6a45489ce2f7d8ee12cedf517
https://doi.org/10.1038/nrc2824
https://doi.org/10.1038/nrc2824
Publikováno v:
Biology of the Cell. 98:353-361
Background information. Ku is an abundant nuclear heterodimeric protein composed of 70 and 86 kDa subunits. As an activator of the catalytic subunit of DNA-PK (DNA-dependent protein kinase), Ku plays an important role in DNA repair and recombination.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de4033cc6cb40877e9a0f8271770fc4
https://doi.org/10.1042/bc20050060
https://doi.org/10.1042/bc20050060
Publikováno v:
Journal of Virology. 71:7841-7850
Recombinant polioviruses expressing foreign antigens may provide a convenient vaccine vector to engender mucosal immunity. Replication-competent chimeric viruses can be constructed by fusing foreign antigenic sequences to several positions within the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c310d0f387373848413f9374adc320c
https://doi.org/10.1128/jvi.71.10.7841-7850.1997
https://doi.org/10.1128/jvi.71.10.7841-7850.1997
Autor:
Komal Jhaveri, Eleonora Teplinsky, F. Darvishian, Judith D. Goldberg, Robert J. Schneider, Francisco J. Esteva, Salman Hashmi, Silvia C. Formenti, Shah Giashuddin, Melissa Alexander, Deborah Silvera, Meena S. Moran, Rezina Arju, Tsivia Hochman, Paul H. Levine, Baljit Singh, Heather J. Hoffman, Ladan Zolfaghari, Amanda Valeta-Magara, Yasmeen Sarfraz
Publikováno v:
Clinical Breast Cancer. 16:113-122.e1
Introduction Inflammatory breast cancer (IBC) is an aggressive and rare cancer with a poor prognosis and a need for novel targeted therapeutic strategies. Preclinical IBC data showed strong activation of the phosphatidylinositide-3-kinase/mammalian t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152afd2523f6b350295c7ce479f49c7d
https://doi.org/10.1016/j.clbc.2015.11.006
https://doi.org/10.1016/j.clbc.2015.11.006
Autor:
Deborah Silvera, Heather J. Hoffman, Tsivia Hochman, Shah Giashuddin, F. Darvishian, Judith D. Goldberg, Melissa Alexander, Amanda Valeta, Komal Jhaveri, R Arzu, L Paul, Moran, Salman Hashmi, Eleonora Teplinsky, Baljit Singh, Yasmeen Sarfraz, S.C. Formenti, Robert J. Schneider, Pascale Levine
Publikováno v:
Cancer Research. 73:PD5-6
Background: IBC is an aggressive form of breast cancer with poor prognosis. Combined multi-modality therapy results in a 5 year OS of 30%, underscoring the unmet need for targeted therapy. Our preclinical research in cell lines & xenograft tumor mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c0f83a7393533b57d0bebbe1d27442f
https://doi.org/10.1158/0008-5472.sabcs13-pd5-6
https://doi.org/10.1158/0008-5472.sabcs13-pd5-6
Autor:
Robert J. Schneider, Deborah Silvera
Publikováno v:
Cell cycle (Georgetown, Tex.). 8(19)
We recently showed that overexpression of translation initiation factor eIF4G partially drives the unusual pathological features of Inflammatory Breast Cancer (IBC), the most lethal form of primary breast cancer. IBC has the peculiar feature that, ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620e3c0f0e914da2b334c62c173353f7
https://pubmed.ncbi.nlm.nih.gov/19755858
https://pubmed.ncbi.nlm.nih.gov/19755858
Autor:
Judith D. Goldberg, Ladan Zolfaghari, Rezina Arju, Farbod Darvishian, Deborah Silvera, Paul H. Levine, Robert J. Schneider, Silvia C. Formenti, Tsivia Hochman
Publikováno v:
Nature cell biology. 11(7)
Inflammatory breast cancer (IBC) is the most lethal form of primary breast cancer. IBC lethality derives from generation of tumour emboli, which are non-adherent cell clusters that rapidly spread by a form of continuous invasion known as passive meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32df014a009012e9c2fb9f1b6e9c671
https://pubmed.ncbi.nlm.nih.gov/19525934
https://pubmed.ncbi.nlm.nih.gov/19525934
Autor:
Deborah Silvera, T. Venuto, M. Badura, Robert J. Schneider, Stephanie V. Blank, Sharmilee Bansal Korets
Publikováno v:
Gynecologic Oncology. 125:S133-S134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8807de83201ea858d712a0932d522fac
https://doi.org/10.1016/j.ygyno.2011.12.326
https://doi.org/10.1016/j.ygyno.2011.12.326