Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Deborah Sanfelice"'
Autor:
Vikas Gupta, Karen W.L. Yee, Deborah Sanfelice, Andre C. Schuh, Aisha Shamas-Din, David W. Hedley, Matthew D. Seftel, Sue Chow, Joseph Brandwein, Aaron D. Schimmer
Publikováno v:
Leukemia & Lymphoma. 57:2437-2440
Elesclomol is a novel, injectable, small molecule chemotherapeutic agent that has demonstrated preclinical efficacy in AML.[1,2] Mechanistically, elesclomol binds copper (Cu) in the form of Cu2+ in...
Autor:
David W. Hedley, Mark D. Minden, Joseph Brandwein, Lisa W. Le, Jamie Arnott, Aaron D. Schimmer, Deborah Sanfelice, Karen W.L. Yee, Mark R. Bray, Sue Chow, Andre C. Schuh, Tara Johnson, C. Sidor, Hsiao-Wei T. Chen, Vikas Gupta
Publikováno v:
Investigational new drugs. 34(5)
ENMD-2076 is a novel, orally-active molecule that inhibits Aurora A kinase, as well as c-Kit, FLT3 and VEGFR2. A phase I study was conducted to determine the maximum tolerated dose (MTD), recommended phase 2 dose (RP2D) and toxicities of ENMD-2076 in
Autor:
Hsaio-Wei Tina Chen, Aaron D. Schimmer, Graham C. Fletcher, David W. Hedley, Mark D. Minden, Joseph Brandwein, Sue Chow, Karen W.L. Yee, Deborah Sanfelice, Jamie Arnott, Andre C. Schuh, Mark R. Bray, C. Sidor, Vikas Gupta
Publikováno v:
Blood. 116:3307-3307
Abstract 3307 Background: ENMD-2076 is a novel, orally-active molecule that inhibits Aurora A kinase and FLT3, as well as multiple receptor tyrosine kinases that drive tumor vascularization, including VEGFR2 (KDR), PDGFR and FGFR. A phase I study was
Autor:
Vikas Gupta, Mark R. Bray, Hsiao‐Wei Tina Chen, Jamie Arnott, David W. Hedley, Sue Chow, Deborah Sanfelice, Karen W.L. Yee, Aaron D. Schimmer, Joseph Brandwein, Mark D. Minden, Graham C. Fletcher, Andre C. Schuh, C. Sidor
Publikováno v:
Molecular Cancer Therapeutics. 8:A106-A106
ENMD-2076 is a novel, orally-active molecule that inhibits Aurora A kinase as well as multiple receptor tyrosine kinases that drive tumor vascularization, including VEGFR2 (KDR), PDGFR and FGFR. A phase 1 study was conducted to determine the maximum