Clonal somatic copy number altered driver events inform drug sensitivity in high-grade serous ovarian cancer

Autor: Filipe Correia Martins, Dominique-Laurent Couturier, Ines de Santiago, Carolin Margarethe Sauer, Maria Vias, Mihaela Angelova, Deborah Sanders, Anna Piskorz, James Hall, Karen Hosking, Anumithra Amirthanayagam, Sabina Cosulich, Larissa Carnevalli, Barry Davies, Thomas B. K. Watkins, Ionut G. Funingana, Helen Bolton, Krishnayan Haldar, John Latimer, Peter Baldwin, Robin Crawford, Matthew Eldridge, Bristi Basu, Mercedes Jimenez-Linan, Andrew W. Mcpherson, Nicholas McGranahan, Kevin Litchfield, Sohrab P. Shah, Iain McNeish, Carlos Caldas, Gerard Evan, Charles Swanton, James D. Brenton

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Chromosomal instability is a major challenge to patient stratification and targeted drug development for high-grade serous ovarian carcinoma. Here we show that identification of clonal somatic copy number alterations in frequently amplified cancer ge

Externí odkaz: https://doaj.org/article/63184752d1ca4e718d39186ab46bf815

Predicting response to cytotoxic chemotherapy

Autor: Laura Madrid, Joseph Thompson, Maria Vias, Maria Escobar-Rey, Wing-Kit Leung, Jamie Huckstep, Magdalena Sekowska, Karen Hosking, Mercedes Jimenez-Linan, Marika Reinius, Carolin Sauer, Harry Dobson, Ángel Fernández-Sanromán, Deborah Sanders, Filipe Correia Martins, Florian Markowetz, Jason Yip, James D Brenton, Ania Piskorz, Geoff Macintyre

Cytotoxic chemotherapies have been a mainstay of cancer treatment for over 40 years. As they are typically administered without the use of precision biomarkers, some patients can suffer severe side effects without any benefit. The development of nove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f48772e41a62da6fa060c3e94930147a
https://doi.org/10.1101/2023.01.28.525988

Can China promote stability in the Black Sea Region?

Autor: Deborah Sanders

Publikováno v: Southeast European and Black Sea Studies. 21:415-436

China has become an increasingly important actor in the Black Sea Region (BSR), and this looks set to continue in the future. Beijing has actively engaged with all of the Black Sea states and has l...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e67d0831eb134ddf20d8cca2776b12e
https://doi.org/10.1080/14683857.2021.1935771

The Rise of China and the Black Sea Region: Opportunities and Challenges for NATO

Autor: DEBORAH SANDERS

Publikováno v: King's College London

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c6115888a5417c3cb95c7d4b1e19639
https://doi.org/10.5771/9783748921011-209

The Ukraine Conflict and the Problems of War Termination

Autor: Christopher Tuck, Deborah Sanders

Publikováno v: Sanders, D & Tuck, C 2020, ' The Ukraine Conflict and the Problems of War Termination ', Journal of Slavic Military Studies, vol. 33, no. 1, pp. 22-43 . https://doi.org/10.1080/13518046.2020.1723219

The war in the east of Ukraine is now in its fifth year and, despite the cost-benefit logic for both sides of securing a peace, the chances of terminating this conflict remain remote. Using the theoretical literature on war termination, this article

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89983d8265e872166288fe6624d395b9
https://kclpure.kcl.ac.uk/en/publications/23ad663a-dfae-473e-9695-6f8a6573435c