Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Deborah S. Malley"'
Autor:
Shani A. Mulholland, David T.W. Jones, Koichi Ichimura, Rifat Hamoudi, Danita M. Pearson, Caroline M. Smith, L. Magnus Bäcklund, V. Peter Collins, Sylvia Kocialkowski, Jamie M J Weaver, Deborah S. Malley
Publikováno v:
International Journal of Cancer. 131:1104-1113
We have previously identified a region containing 16 CpGs within the MGMT CpG islands which is critical for the transcriptional control of MGMT (Malley, Acta Neuropathol 2011). To investigate the patterns and incidence of MGMT methylation in astrocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd6372a2172041e8d877e0cee792cbc
https://doi.org/10.1002/ijc.26499
https://doi.org/10.1002/ijc.26499
Autor:
Rifat Hamoudi, Sylvia Kocialkowski, Vincent Peter Collins, Danita M. Pearson, Deborah S. Malley, Koichi Ichimura
Publikováno v:
Acta Neuropathologica. 121:651-661
O(6)-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein that removes alkyl DNA adducts such as those induced by alkylating agents. Loss of MGMT expression through transcriptional silencing by hypermethylation of its CpG island (CGI) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89888c845234426898c8cdbf23ae3857
https://doi.org/10.1007/s00401-011-0803-5
https://doi.org/10.1007/s00401-011-0803-5
Publikováno v:
Neuropathology and Applied Neurobiology. 36:505-514
P. J. Kullar, D. M. Pearson, D. S. Malley, V. P. Collins and K. Ichimura (2010) Neuropathology and Applied Neurobiology36, 505–514 CpG island hypermethylation of the neurofibromatosis type 2 (NF2) gene is rare in sporadic vestibular schwannomas Aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95056adc8aa1ed0865c0cad9067e4484
https://doi.org/10.1111/j.1365-2990.2010.01090.x
https://doi.org/10.1111/j.1365-2990.2010.01090.x
Autor:
Shani A. Mulholland, Deborah S. Malley, Samuel W. S. Openshaw, David T.W. Jones, Koichi Ichimura, Lu Liu, V. Peter Collins, Sally R. Lambert, L. Magnus Bäcklund, Danita M. Pearson
Publikováno v:
Acta neuropathologica. 121(6)
Diffuse astrocytomas (WHO grade II) typically present as slow-growing tumours showing significant cellular differentiation, but possessing a tendency towards malignant progression. They account for ~10% of all astrocytic tumours, with a peak incidenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40707d319f84cf8f2f7a5c77ca094783
https://pubmed.ncbi.nlm.nih.gov/21327941
https://pubmed.ncbi.nlm.nih.gov/21327941
Publikováno v:
Cancer Research. 71:LB-181
Introduction: Astrocytomas are the most common subtype of glioma, accounting for about 70% of all malignant tumors found in the central nervous system. Genetic alterations in gliomas have been extensively researched, but epigenetic changes are less w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aff0455389bcb490fc2cefac591d4513
https://doi.org/10.1158/1538-7445.am2011-lb-181
https://doi.org/10.1158/1538-7445.am2011-lb-181
Autor:
Koichi Ichimura, Shani A. Mulholland, Sylvia Kocialkowski, D. Pearson, Rifat Hamoudi, V. Peter Collins, Deborah S. Malley
Publikováno v:
Cancer Research. 71:2794-2794
Background: Astrocytic, oligodendroglial and oligoastrocytic tumors are major subtypes of human gliomas, which are the most common malignant primary brain tumor. IDH1/IDH2 mutations are found in more than 50% of WHO grade II and III tumors in each of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4233b08bc9a863f93fddc3f2e495bf0d
https://doi.org/10.1158/1538-7445.am2011-2794
https://doi.org/10.1158/1538-7445.am2011-2794