Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Deborah S. Cunninghame-Graham"'
Autor:
Yuxuan Wang, Suri Guga, Kejia Wu, Zoe Khaw, Konstantinos Tzoumkas, Phil Tombleson, Mary E Comeau, Carl D Langefeld, Deborah S Cunninghame Graham, David L Morris, Timothy J Vyse
Publikováno v:
PLoS Genetics, Vol 18, Iss 11, p e1010253 (2022)
Genome wide association studies show there is a genetic component to severe COVID-19. We find evidence that the genome-wide genetic association signal with severe COVID-19 is correlated with that of systemic lupus erythematosus (SLE), having formally
Externí odkaz:
https://doaj.org/article/a5da860cf869428e9d470798b580693c
Autor:
Christopher A. Odhams, Amy L. Roberts, Susan K. Vester, Carolina S. T. Duarte, Charlie T. Beales, Alexander J. Clarke, Sonja Lindinger, Samuel J. Daffern, Antonino Zito, Lingyan Chen, Leonardo L. Jones, Lora Boteva, David L. Morris, Kerrin S. Small, Michelle M. A. Fernando, Deborah S. Cunninghame Graham, Timothy J. Vyse
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Systemic lupus erythematosus (SLE) shows a striking bias towards higher prevalence in females. Here, the authors perform fine-mapping of an SLE-associated locus at Xp21.2 and characterise a candidate gene, CXorf21, as IFN-responsive in immune cells t
Externí odkaz:
https://doaj.org/article/26e43468667241ccb8271a65e26175aa
Autor:
Carl D. Langefeld, Hannah C. Ainsworth, Deborah S. Cunninghame Graham, Jennifer A. Kelly, Mary E. Comeau, Miranda C. Marion, Timothy D. Howard, Paula S. Ramos, Jennifer A. Croker, David L. Morris, Johanna K. Sandling, Jonas Carlsson Almlöf, Eduardo M. Acevedo-Vásquez, Graciela S. Alarcón, Alejandra M. Babini, Vicente Baca, Anders A. Bengtsson, Guillermo A. Berbotto, Marc Bijl, Elizabeth E. Brown, Hermine I. Brunner, Mario H. Cardiel, Luis Catoggio, Ricard Cervera, Jorge M. Cucho-Venegas, Solbritt Rantapää Dahlqvist, Sandra D’Alfonso, Berta Martins Da Silva, Iñigo de la Rúa Figueroa, Andrea Doria, Jeffrey C. Edberg, Emőke Endreffy, Jorge A. Esquivel-Valerio, Paul R. Fortin, Barry I. Freedman, Johan Frostegård, Mercedes A. García, Ignacio García de la Torre, Gary S. Gilkeson, Dafna D. Gladman, Iva Gunnarsson, Joel M. Guthridge, Jennifer L. Huggins, Judith A. James, Cees G. M. Kallenberg, Diane L. Kamen, David R. Karp, Kenneth M. Kaufman, Leah C. Kottyan, László Kovács, Helle Laustrup, Bernard R. Lauwerys, Quan-Zhen Li, Marco A. Maradiaga-Ceceña, Javier Martín, Joseph M. McCune, David R. McWilliams, Joan T. Merrill, Pedro Miranda, José F. Moctezuma, Swapan K. Nath, Timothy B. Niewold, Lorena Orozco, Norberto Ortego-Centeno, Michelle Petri, Christian A. Pineau, Bernardo A. Pons-Estel, Janet Pope, Prithvi Raj, Rosalind Ramsey-Goldman, John D. Reveille, Laurie P. Russell, José M. Sabio, Carlos A. Aguilar-Salinas, Hugo R. Scherbarth, Raffaella Scorza, Michael F. Seldin, Christopher Sjöwall, Elisabet Svenungsson, Susan D. Thompson, Sergio M. A. Toloza, Lennart Truedsson, Teresa Tusié-Luna, Carlos Vasconcelos, Luis M. Vilá, Daniel J. Wallace, Michael H. Weisman, Joan E. Wither, Tushar Bhangale, Jorge R. Oksenberg, John D. Rioux, Peter K. Gregersen, Ann-Christine Syvänen, Lars Rönnblom, Lindsey A. Criswell, Chaim O. Jacob, Kathy L. Sivils, Betty P. Tsao, Laura E. Schanberg, Timothy W. Behrens, Earl D. Silverman, Marta E. Alarcón-Riquelme, Robert P. Kimberly, John B. Harley, Edward K. Wakeland, Robert R. Graham, Patrick M. Gaffney, Timothy J. Vyse
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong ethnic and gender bias. In a transancestral genetic association study, Langefeldet al. identify 24 novel regions associated with risk to lupus and propose a cumulative hits hyp
Externí odkaz:
https://doaj.org/article/a68227bc3ba0457486591e4743061bf9
Publikováno v:
PLoS Genetics, Vol 13, Iss 10, p e1007071 (2017)
Genome-wide association studies have identified hundreds of risk loci for autoimmune disease, yet only a minority (~25%) share genetic effects with changes to gene expression (eQTLs) in immune cells. RNA-Seq based quantification at whole-gene resolut
Externí odkaz:
https://doaj.org/article/a2a3a10683114beeb26dea5fe28d62b6
Autor:
He Li, Tove Ragna Reksten, John A Ice, Jennifer A Kelly, Indra Adrianto, Astrid Rasmussen, Shaofeng Wang, Bo He, Kiely M Grundahl, Stuart B Glenn, Corinne Miceli-Richard, Simon Bowman, Sue Lester, Per Eriksson, Maija-Leena Eloranta, Johan G Brun, Lasse G Gøransson, Erna Harboe, Joel M Guthridge, Kenneth M Kaufman, Marika Kvarnström, Deborah S Cunninghame Graham, Ketan Patel, Adam J Adler, A Darise Farris, Michael T Brennan, James Chodosh, Rajaram Gopalakrishnan, Michael H Weisman, Swamy Venuturupalli, Daniel J Wallace, Kimberly S Hefner, Glen D Houston, Andrew J W Huang, Pamela J Hughes, David M Lewis, Lida Radfar, Evan S Vista, Contessa E Edgar, Michael D Rohrer, Donald U Stone, Timothy J Vyse, John B Harley, Patrick M Gaffney, Judith A James, Sean Turner, Ilias Alevizos, Juan-Manuel Anaya, Nelson L Rhodus, Barbara M Segal, Courtney G Montgomery, R Hal Scofield, Susan Kovats, Xavier Mariette, Lars Rönnblom, Torsten Witte, Maureen Rischmueller, Marie Wahren-Herlenius, Roald Omdal, Roland Jonsson, Wan-Fai Ng, for UK Primary Sjögren's Syndrome Registry, Gunnel Nordmark, Christopher J Lessard, Kathy L Sivils
Publikováno v:
PLoS Genetics, Vol 13, Iss 6, p e1006820 (2017)
Sjögren's syndrome (SS) is a common, autoimmune exocrinopathy distinguished by keratoconjunctivitis sicca and xerostomia. Patients frequently develop serious complications including lymphoma, pulmonary dysfunction, neuropathy, vasculitis, and debili
Externí odkaz:
https://doaj.org/article/de75960e36dc428c8be5c64c20d692ba
Autor:
Sharon A. Chung, Gökhan Keser, Ayten Yazici, Zeynep Ozbalkan, R. Maughan, Servet Akar, Fatma Alibaz-Oner, Nurullah Akkoc, Kathleen McKinnon-Maksimowicz, Patrick Coit, Güher Saruhan-Direskeneli, Chris Wallace, Omer Karadag, Muge Bicakcigil, Antoine G. Sreih, Ahmet Mesut Onat, Paul A. Monach, Ying Sun, Kenan Aksu, Carol A. Langford, Mehmet Akif Ozturk, Izzet Fresko, Eren Erken, Lindsay Lally, Lindsy J. Forbess, Christian Pagnoux, Ayse Cefle, Ediz Dalkilic, Timothy J. Vyse, Veli Cobankara, Peter C. Grayson, Guillermo Reales, David Cuthbertson, Philip Seo, Gozde Yildirim Cetin, Curry L. Koening, Sibel P. Yentür, Yaşar Karaaslan, Lourdes Ortiz-Fernández, Nilufer Alpay-Kanitez, Bunyamin Kisacik, Xiufang Kong, Sibel Zehra Aydin, Enrico Tombetti, Sule Yavuz, Lindi Jiang, Fatos Onen, Allan P. Kiprianos, Nurşen Düzgün, Nader Khalidi, Justin C. Mason, Huiyong Chen, Aşkın Ateş, Angelo A. Manfredi, Murat Inanc, Sevil Kamali, Sema Kaymaz-Tahra, Steven R. Ytterberg, Timuçin Kaşifoğlu, Emire Seyahi, Elena Baldissera, Deborah S. Cunninghame-Graham, Sedat Kiraz, Jason M. Springer, Peter A. Merkel, Haner Direskeneli, Jonathan D. Wren, Kenneth J. Warrington, Carol A. McAlear, Amr H. Sawalha, Huseyin T. E. Ozer
Publikováno v:
Am J Hum Genet
Takayasu arteritis is a rare inflammatory disease of large arteries. We performed a genetic study in Takayasu arteritis comprising 6,670 individuals (1,226 affected individuals) from five different populations. We discovered HLA risk factors and four
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa13832c2b14faa262d03689dbb58d8b
https://doi.org/10.1016/j.ajhg.2020.11.014
https://doi.org/10.1016/j.ajhg.2020.11.014
Publikováno v:
International Journal of Molecular Sciences
Background: Prioritizing tag-SNPs carried on extended risk haplotypes at susceptibility loci for common disease is a challenge. Methods: We utilized trans-ancestral exclusion mapping to reduce risk haplotypes at IKZF1 and IKZF3 identified in multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::20d4783582e791ed6b1d0bca9b9f97d1
https://pubmed.ncbi.nlm.nih.gov/33182226
https://pubmed.ncbi.nlm.nih.gov/33182226
Autor:
Xuejun Zhang, Lingyan Chen, Deborah S. Cunninghame Graham, Wangling Yang, David L. Morris, Yong-Fei Wang, Lu Liu, Adrianna Bielowka, Phil Tombleson, Christopher A. Odhams, Rahell Ahmed, Huoru Zhang, Amy L. Roberts, Timothy J. Vyse
Publikováno v:
Chen, L, Wang, Y F, Liu, L, Bielowka, A, Ahmed, R, Zhang, H, Tombleson, P, Roberts, A L, Odhams, C A, Cunninghame Graham, D S, Zhang, X, Yang, W, Vyse, T J & Morris, D L 2020, ' Genome-wide assessment of genetic risk for systemic lupus erythematosus and disease severity ', Human Molecular Genetics, vol. 29, no. 10, ddaa030, pp. 1745-1756 . https://doi.org/10.1093/hmg/ddaa030
Human Molecular Genetics
Human Molecular Genetics
ObjectiveUsing three European and two Chinese genome-wide association studies (GWAS), we investigated the performance of genetic risk scores (GRS) for predicting the susceptibility and severity of Systemic lupus erythematosus (SLE), using renal disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eefcb199a1e215a418b77741f7f46f24
Autor:
Deborah S Cunninghame Graham, David L Morris, Tushar R Bhangale, Lindsey A Criswell, Ann-Christine Syvänen, Lars Rönnblom, Timothy W Behrens, Robert R Graham, Timothy J Vyse
Publikováno v:
PLoS Genetics, Vol 7, Iss 10, p e1002341 (2011)
Systemic lupus erythematosus (SLE) is a complex trait characterised by the production of a range of auto-antibodies and a diverse set of clinical phenotypes. Currently, ~8% of the genetic contribution to SLE in Europeans is known, following publicati
Externí odkaz:
https://doaj.org/article/64c859e6432d4d708edf4eebf304408a
Publikováno v:
Abstracts.
Background Pinpointing causal risk alleles, carried on extended risk haplotypes, at susceptibility loci for common disease is challenging. We present a novel strategy to prioritise tag-SNPs at risk loci with the highest likelihood of biological relev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31ee4c8fa32a53a3f16d51cf1a4c30a8
https://doi.org/10.1136/lupus-2019-lsm.240
https://doi.org/10.1136/lupus-2019-lsm.240