Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Deborah S. Cooper"'
Autor:
Marla Gearing, Hong Pang, Hyder A. Jinnah, Diane J. Sutcliffe, Cecília N. Prudente, Martin Göttle, Jonathan D. Glass, Rong Fu, Jasper E. Visser, Emir Veledar, Deborah S. Cooper
Publikováno v:
Annals of Neurology. 76:95-107
Lesch–Nyhan disease (LND) is an inherited disorder with a characteristic neurobehavioral phenotype that includes a movement disorder dominated by generalized dystonia, intellectual disability, and recurrent self-injurious behavior.1–4 The disorde
Autor:
Marcela Catano, Jialing Wu, Ramiro Echeverry, Manuel Yepes, Woldeab B. Haile, Jie An, Fang Wu, Deborah S. Cooper
Publikováno v:
Molecular and Cellular Neuroscience. 52:9-19
The release of the serine proteinase tissue-type plasminogen activator (tPA) from cerebral cortical neurons has a neuroprotective effect in the ischemic brain. Because excitotoxicity is a basic mechanism of ischemia-induced cell death, here we invest
Autor:
Jonathan D. Glass, Li Ku, Marla Gearing, Yue Feng, Nicholas T. Seyfried, Deborah S. Cooper, Junmin Peng, Laura E. Donovan, Qiangwei Xia, Jianjun Chang, Eric B. Dammer, James J. Lah, Duc M. Duong, Howard D. Rees, Allan I. Levey, Malú G. Tansey, Yair M. Gozal, Jeremy H. Herskowitz
Publikováno v:
Journal of Proteome Research. 11:2721-2738
A hallmark of neurodegeneration is the aggregation of disease related proteins that are resistant to detergent extraction. In the major pathological subtype of frontotemporal lobar degeneration (FTLD), modified TAR-DNA binding protein 43 (TDP-43), in
Autor:
Marla Gearing, Terrell E. Brotherton, Jeffrey D. Rothstein, Kevin B. Boylan, Yingjie Li, Jean-Pierre Julien, Deborah S. Cooper, Jonathan D. Glass
Publikováno v:
Proceedings of the National Academy of Sciences. 109:5505-5510
Mutations in the gene encoding superoxide dismutase 1 (SOD1) account for about 20% of the cases of familial amyotrophic lateral sclerosis (fALS). It is not known how the mutant protein causes disease, or why only a subset of cell types (motor neurons
Publikováno v:
Experimental Physiology. 94:1114-1123
The Na+–HCO3– cotransporter NBCn1 (SLC4A7) has multiple variants depending upon splice domains in the cytoplasmic amino- and carboxy-termini of the protein. In this study, we examined the role of the amino-terminal splice domain containing 123 am
Autor:
C. Chris Yun, Eunjin Kim, Peijian He, Ira Rajbhandari, Han Soo Yang, Deborah S. Cooper, Inyeong Choi
Publikováno v:
European Journal of Neuroscience. 29:437-446
Growing evidence suggests that pharmacological inhibition of Na/H exchange and Na/HCO(3) transport provides protection against damage or injury in cardiac ischemia. In this study, we examined the contribution of the sodium/bicarbonate cotransporter N
Autor:
James J. Lah, Chadwick M. Hales, Deborah S. Cooper, Stewart Neill, Marla Gearing, Jonathan D. Glass
Publikováno v:
Neurology. 83(24)
Chronic traumatic encephalopathy (CTE) is a syndrome that manifests with behavioral disturbance and cognitive decline in patients with repetitive head trauma.1 The syndrome was first described in boxers in the 1920s,2 but there are concerns that othe
Publikováno v:
Journal of Biomedical Science. 13:593-595
In this study, we examined the tissue-specific expression of two electroneutral Na/HCO(3) cotransporter (NBCn1) variants that differ from each other by the presence of the N-terminal 123 amino acids (cassette II). A rat Northern blot with the probe t
Autor:
Marla Gearing, Dipan Karmali, Carson D. Van Sanford, Deborah S. Cooper, Adam L. Orr, Ranjita Betarbet, Elaine L. Pranski, Nirjari V. Dalal, James J. Lah, Allan I. Levey
RING finger protein 11 (RNF11), a negative regulator of NF-κB signaling pathway, colocalizes with α-synuclein and is sequestered in Lewy bodies in Parkinson's disease (PD). Since persistent NF-κB activation is reported in PD, in this report we inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14b1b5333df85c40981f83eb00f49c3
https://europepmc.org/articles/PMC3699785/
https://europepmc.org/articles/PMC3699785/
Autor:
Adam L. Orr, Elaine L. Pranski, Carson D. Van Sanford, Deborah S. Cooper, Craig J. Heilman, Ranjita Betarbet, Marla Gearing, James J. Lah, Allan I. Levey, Dipan Karmali, Nichole Costa, Nirjari V. Dalal
Publikováno v:
Neuroscience letters. 520(1)
Activation of innate and adaptive immune responses is tightly regulated, as insufficient activation could result in defective clearance of pathogens, while excessive activation might lead to lethal systemic inflammation or autoimmunity. A20 functions