Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Deborah R. Wysong"'
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
PDF file - 34K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd0a58f7cbd736328e57e7a23f7e5ec
https://doi.org/10.1158/1078-0432.22446309.v1
https://doi.org/10.1158/1078-0432.22446309.v1
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
Purpose: Small-molecule inhibitors of Aurora A (AAK) and B (ABK) kinases, which play important roles in mitosis, are currently being pursued in oncology clinical trials. We developed three novel assays to quantitatively measure biomarkers of AAK inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2b8c17037133a1bc1c17abc8089fa3
https://doi.org/10.1158/1078-0432.c.6520713
https://doi.org/10.1158/1078-0432.c.6520713
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
PDF file - 27K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::889d43f96b1d811fca5e3c164e018a19
https://doi.org/10.1158/1078-0432.22446306
https://doi.org/10.1158/1078-0432.22446306
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
PDF file - 65K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9737acec25fe2137ea4f1aa5f53a36c5
https://doi.org/10.1158/1078-0432.22446312.v1
https://doi.org/10.1158/1078-0432.22446312.v1
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
PDF file - 36K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fa6e54e4641152cddff0837b8a5697
https://doi.org/10.1158/1078-0432.22446315
https://doi.org/10.1158/1078-0432.22446315
Autor:
Todd B. Sells, Ryan Chau, Jeffrey A. Ecsedy, Rachel E. Gershman, Kara Hoar, Jessica Huck, David A. Janowick, Vivek J. Kadambi, Patrick J. LeRoy, Matthew Stirling, Stephen G. Stroud, Tricia J. Vos, Gabriel S. Weatherhead, Deborah R. Wysong, Mengkun Zhang, Suresh K. Balani, Joseph B. Bolen, Mark G. Manfredi, Christopher F. Claiborne
Publikováno v:
ACS Medicinal Chemistry Letters. 6:630-634
The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, select
Autor:
Vaishali Shinde, Stephen G. Stroud, Melissa S. Germanos, Mengkun Zhang, Wei Chen, Sells Todd B, Deborah R. Wysong, Arijit Chakravarty, Matthew D. Silva, Marc L. Hyer, Mark Manfredi, Christopher F. Claiborne, Jeffrey Ecsedy, Patrick J. LeRoy, Jessica Huck, Lee Silverman, David A. Janowick, Kara Hoar, Joseph B. Bolen, Rachel E. Gershman
Publikováno v:
Clinical Cancer Research. 17:7614-7624
Purpose: Small-molecule inhibitors of Aurora A (AAK) and B (ABK) kinases, which play important roles in mitosis, are currently being pursued in oncology clinical trials. We developed three novel assays to quantitatively measure biomarkers of AAK inhi
Publikováno v:
Cell Cycle. 8:876-888
The spindle assembly checkpoint functions during mitosis to ensure that chromosomes are properly aligned in mitotic cells prior to the onset of anaphase, thereby ensuring an equal segregation of genetic material to each daughter cell. Defects in the
Autor:
Deborah R. Wysong, Tony Wood, Patrick R. Errada, Tanya Parkinson, Karen J. McGovern, Ian M. Willis, Ronald K. Blackman, Liping Wu, Alexandra E. Gould, Vala Thoroddsen, Timothy D. Ocain, Daniel Kornitzer, Lawrence R. Dick, Patrick Dorr, Christine E. Bulawa, Jing Pan, Ziva Weissman
Publikováno v:
Eukaryotic Cell. 2:256-264
A genetic approach utilizing the yeast Saccharomyces cerevisiae was used to identify the target of antifungal compounds. This analysis led to the identification of small molecule inhibitors of RNA polymerase (Pol) III from Saccharomyces cerevisiae .
Autor:
Deborah R. Wysong, Ryan Hastey, Tova Meshulam, Elizabeth R. Simons, Richard D. Diamond, Laurent Christin
Publikováno v:
Infection and Immunity. 66:1181-1189
Neutropenia is considered a significant risk factor for invasive aspergillosis but is almost always associated with concurrent thrombocytopenia. Studies determined that platelets, like neutrophils, attached to cell walls of the invasive hyphal form o