Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Deborah R. Gill"'
Autor:
Killian Hurley, Mari Ozaki, Quentin Philippot, Liam Galvin, David Crosby, Mary Kirwan, Deborah R. Gill, Konstantinos-Dionysios Alysandratos, Gisli Jenkins, Matthias Griese, Nadia Nathan, Raphael Borie, Deborah Snijders, Nicolaus Schwerk, Nico Lachmann, Daniel O'Toole
Publikováno v:
EBioMedicine, Vol 104, Iss , Pp 105135- (2024)
Summary: Interstitial lung diseases (ILDs) in adults and children (chILD) are a heterogeneous group of lung disorders leading to inflammation, abnormal tissue repair and scarring of the lung parenchyma often resulting in respiratory failure and death
Externí odkaz:
https://doaj.org/article/d1a53dcebee04116a10cbbac5081b2fb
Autor:
Rosie J. Munday, Tiziana Coradin, Rachael Nimmo, Yatish Lad, Stephen C. Hyde, Kyriacos Mitrophanos, Deborah R. Gill
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 239-252 (2022)
A lentiviral vector (LV) pseudotype derived from the fusion (F) and hemagglutinin-neuraminidase (HN) glycoproteins of a murine respirovirus (Sendai virus) facilitates efficient targeting of murine lung in vivo. Since targeting of the human lung will
Externí odkaz:
https://doaj.org/article/241605041a2345d097db4e7ae694bd95
Autor:
Helena Lund-Palau, Claudia Ivette Juarez-Molina, Cuixiang Meng, Anushka Bhargava, Aikaterini Pilou, Kiran Aziz, Nora Clarke, Naoko Atsumi, Ali Ashek, Michael R. Wilson, Masao Takata, Simon Padley, Deborah R. Gill, Stephen C. Hyde, Cliff Morgan, Eric W.F.W. Alton, Uta Griesenbach
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 382-391 (2022)
We developed a novel lentiviral vector, pseudotyped with the F and HN proteins from Sendai virus (rSIV.F/HN), that produces long-lasting, high-efficiency transduction of the respiratory epithelium. Here we addressed whether this platform technology c
Externí odkaz:
https://doaj.org/article/4c2433997a7f402b8741006400d6273c
Autor:
Altar M. Munis, Benjamin Wright, Frederic Jackson, Helen Lockstone, Stephen C. Hyde, Catherine M. Green, Deborah R. Gill
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 62-70 (2022)
Understanding pulmonary diseases requires robust culture models that are reproducible, sustainable in long-term culture, physiologically relevant, and suitable for assessment of therapeutic interventions. Primary human lung cells are physiologically
Externí odkaz:
https://doaj.org/article/81b582810f854445b47efeadc72469e4
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Epidemiological efforts to model the spread of SARS-CoV-2, the virus that causes COVID-19, are crucial to understanding and containing current and future outbreaks and to inform public health responses. Mutations that occur in viral genomes
Externí odkaz:
https://doaj.org/article/0f5350e19d5d4b4dbc98ab52f66eb2ac
Autor:
Agata Antepowicz, Omar Habib, Freja Kirsebom, Cecilia Johansson, Deborah R. Gill, Stephen C. Hyde
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Respiratory syncytial virus (RSV) infection is a common cause of hospitalisation in infants and the elderly. Palivizumab prophylaxis is the only approved treatment modality but is costly and only offered to select vulnerable populations. Her
Externí odkaz:
https://doaj.org/article/02a847cbdd3747d0b7746de8f6676a1b
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 237-246 (2021)
Surfactant protein B (SPB) deficiency is a severe monogenic interstitial lung disorder that leads to loss of life in infants as a result of alveolar collapse and respiratory distress syndrome. The development and assessment of curative therapies for
Externí odkaz:
https://doaj.org/article/ce065d88a2414cff8e78d523fca519d4
Autor:
Yue Du, Shengnan Zhang, Zhaoyong Zhang, Kamran M. Miah, Peilan Wei, Lu Zhang, Yuhui Zhu, Zhengtu Li, Feng Ye, Deborah R. Gill, Stephen C. Hyde, Yanqun Wang, Jincun Zhao
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Vaccines for COVID-19 are now a crucial public health need, but the degree of protection provided by conventional vaccinations for individuals with compromised immune systems is unclear. The use of viral vectors to express neutralizing monoclonal ant
Externí odkaz:
https://doaj.org/article/882b0663b0c74c2d88e868f70d05fc7a
Autor:
Helena Meyer-Berg, Lucia Zhou Yang, María Pilar de Lucas, Alberto Zambrano, Stephen C. Hyde, Deborah R. Gill
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-6 (2020)
Abstract Gene therapy is being investigated for a range of serious lung diseases, such as cystic fibrosis and emphysema. Recombinant adeno-associated virus (rAAV) is a well-established, safe, viral vector for gene delivery with multiple naturally occ
Externí odkaz:
https://doaj.org/article/cfd60483467343929fab9a7c02913e3f
Autor:
Lee A. Davies, Graciela A. Nunez-Alonso, Henry L. Hebel, Ron K. Scheule, Seng H. Cheng, Stephen C. Hyde, Deborah R. Gill
Publikováno v:
BioTechniques, Vol 49, Iss 3, Pp 666-668 (2010)
Nonviral gene therapy utilizing plasmid DNA (pDNA) complexed with cationic lipids (lipoplexes) or cationic polymers (polyplexes) has demonstrated considerable potential for the treatment of a variety of diseases. However, progress toward clinical app
Externí odkaz:
https://doaj.org/article/3e046d23ba124e4cbd0b7377bfd128a7