Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Deborah R. Davis"'
Autor:
Maria Alicia Carrillo-Sepulveda, Henry L Keen, Deborah R Davis, Justin L Grobe, Curt D Sigmund
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103786 (2014)
Peroxisome proliferator activated receptor γ (PPARγ) has been reported to play a protective role in the vasculature; however, the underlying mechanisms involved are not entirely known. We previously showed that vascular smooth muscle-specific overe
Externí odkaz:
https://doaj.org/article/afcd487d48c047aeb58c32d084f1394e
Autor:
Tayfun Ates, Deniz Atasoy, İltan Aklan, İlknur Çoban, Witold Konopka, Huxing Cui, Nilufer Sayar Atasoy, Merve Öncül, Fulya Köksalar, Gizem Filiz, Iskalen Cansu Topcu, Karolina Hajdukiewicz, Utku Cebecioğlu, Muhammed Ikbal Alp, Pelin Dilsiz, Deborah R. Davis, Yavuz Yavuz, Kenji Saito, Bayram Yilmaz
Publikováno v:
Cell Metab
Glucose is the essential energy source for the brain, whose deficit, triggered by energy deprivation or therapeutic agents, can be fatal. Increased appetite is the key behavioral defense against hypoglycemia; however, the central pathways involved ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da62397bddfc71ea776b6c6460ab8879
https://hdl.handle.net/20.500.12511/5121
https://hdl.handle.net/20.500.12511/5121
Autor:
Frederick W. Quelle, Curt D. Sigmund, Ko-Ting Lu, Jeffrey D. Singer, James A. McCormick, Henry L. Keen, Larry N. Agbor, Anand R. Nair, Jing Wu, Deborah R. Davis
Patients with mutations in Cullin-3 (CUL3) exhibit severe early onset hypertension but the contribution of the smooth muscle remains unclear. Conditional genetic ablation of CUL3 in vascular smooth muscle (S-CUL3KO) causes progressive impairment in r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5f224eac7626721b7cc665c8365457
https://europepmc.org/articles/PMC6675584/
https://europepmc.org/articles/PMC6675584/
Publikováno v:
Physiological Genomics. 48:124-134
The ligand activated nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) in the endothelium regulates vascular function and blood pressure (BP). We previously reported that transgenic mice (E-V290M) with selectively targeted endot
Autor:
Larry N. Agbor, Henry L. Keen, Frederick W. Quelle, Ko-Ting Lu, Jing Wu, Jeffrey D. Singer, James A. McCormick, Deborah R. Davis, Curt D. Sigmund, Anand R. Nair
Publikováno v:
The FASEB Journal. 32
Autor:
Larry N Agbor, Anand Nair, Jing Wu, Deborah R Davis, Henry L Keen, Frederick W Quelle, James A McCormick, Jeffrey D Singer, Curt D Sigmund
Publikováno v:
Hypertension. 70
Mutations in Cullin-3 ( Cul3 ) resulting in exon 9 skipping (CUL3α9) cause human hypertension. We demonstrated that selective expression of CUL3α9 in smooth muscle causes arterial stiffness and hypertension. We hypothesized that deletion of CUL3 in
Autor:
Deborah R. Davis, Curt D. Sigmund, Jing Wu, Chunyan Hu, Xuebo Liu, Henry L. Keen, Stella-Rita C Ibeawuchi, Ko-Ting Lu, Silke Vogel, Frederick W. Quelle
Publikováno v:
JCI Insight. 2
Impaired PPARγ activity in endothelial cells causes oxidative stress and endothelial dysfunction which causes a predisposition to hypertension, but the identity of key PPARγ target genes that protect the endothelium remain unclear. Retinol-binding
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 307:R376-R386
Increased activity of the renin-angiotensin system within the brain elevates fluid intake, blood pressure, and resting metabolic rate. Renin and angiotensinogen are coexpressed within the same cells of the subfornical organ, and the production and ac
Autor:
Henry L. Keen, Jing Wu, Chunyan Hu, Stella-Rita C Ibeawuchi, Deborah R. Davis, Curt D. Sigmund, Larry N. Agbor, Frederick W. Quelle
Publikováno v:
JCI Insight. 1
Cullin-3 (CUL3) mutations (CUL3Δ9) were previously identified in hypertensive patients with pseudohypoaldosteronism type-II (PHAII), but the mechanism causing hypertension and whether this is driven by renal tubular or extratubular mechanisms remain
Autor:
Keisuke Shinohara, Deborah R. Davis, Martin D. Cassell, Justin L. Grobe, Curt D. Sigmund, Donald A. Morgan, Maria Luisa S. Sequeira-Lopez, Kamal Rahmouni, Xuebo Liu
The renin–angiotensin system (RAS) in the brain is a critical determinant of blood pressure, but the mechanisms regulating RAS activity in the brain remain unclear. Expression of brain renin (renin-b) occurs from an alternative promoter-first exon.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c8dda9989598865cc926cdc55e67e1
https://europepmc.org/articles/PMC5159235/
https://europepmc.org/articles/PMC5159235/