Low unspliced cell-associated HIV RNA in early treated adolescents living with HIV on long suppressive ART

Autor: Kathleen Gärtner, Sara Domínguez-Rodríguez, Judith Heaney, Triantafylia Gkouleli, Paul Grant, Karim Dorgham, Delphine Sauce, Cathia Soulie, Eloise J. Busby, Denise M. O’Sullivan, Moira Spyer, Johannes C. Botha, Maria Angeles Muñoz-Fernandez, Alfredo Tagarro, Nicola Cotugno, Jim F. Huggett, Nigel Klein, Paolo Palma, Pablo Rojo Conejo, Caroline Foster, Carlo Giaquinto, Paolo Rossi, Deborah Persaud, Anita De Rossi, Anne-Geneviève Marcelin, Eleni Nastouli

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionInitiation of antiretroviral treatment (ART) in patients early after HIV-infection and long-term suppression leads to low or undetectable levels of HIV RNA and cell-associated (CA) HIV DNA and RNA. Both CA-DNA and CA-RNA, overestimate the

Externí odkaz: https://doaj.org/article/4ff5de9e0e7d46feaef69aac5332bac4

Assessing the Variability of Cell-Associated HIV DNA Quantification through a Multicenter Collaborative Study

Autor: Yann Le Duff, Kathleen Gärtner, Eloise J. Busby, Annalisa Dalzini, Sivapragashini Danaviah, José Luis Jiménez Fuentes, Carlo Giaquinto, Jim F. Huggett, Matthew Hurley, Anne-Geneviève Marcellin, María Ángeles Muñoz-Fernández, Denise M. O’Sullivan, Deborah Persaud, Laura Powell, Peter Rigsby, Paolo Rossi, Anita de Rossi, Lilly Siems, Theresa Smit, Sarah A. Watters, Neil Almond, Eleni Nastouli

Publikováno v: Microbiology Spectrum, Vol 10, Iss 3 (2022)

ABSTRACT Reliable and accurate quantification of cell-associated HIV DNA (CA HIV DNA) is critical for early infant diagnosis, clinical management of patients under therapy, and to inform new therapeutics efficacy. The present study assessed the varia

Externí odkaz: https://doaj.org/article/94c480c573cc4c8dacfb127ce8fbdce8

Determinants of B-Cell Compartment Hyperactivation in European Adolescents Living With Perinatally Acquired HIV-1 After Over 10 Years of Suppressive Therapy

Autor: Alessandra Ruggiero, Giuseppe Rubens Pascucci, Nicola Cotugno, Sara Domínguez-Rodríguez, Stefano Rinaldi, Alfredo Tagarro, Pablo Rojo, Caroline Foster, Alasdair Bamford, Anita De Rossi, Eleni Nastouli, Nigel Klein, Elena Morrocchi, Benoit Fatou, Kinga K. Smolen, Al Ozonoff, Michela Di Pastena, Katherine Luzuriaga, Hanno Steen, Carlo Giaquinto, Philip Goulder, Paolo Rossi, Ofer Levy, Savita Pahwa, Paolo Palma, the EPIICAL Consortium, Mark Cotton, Shaun Barnabas, Thanyawee Puthanakit, Louise Kuhn, Andrew Yates, Avy Violari, Kennedy Otwombe, Paula Vaz, Maria Grazia Lain, Tacilta Nampossa, Denise Naniche, Sheila Fernandez-Luis, Elisa Lopez, Holly Peay, Moira Spyer, Vincent Calvez, Anne-Genevieve Marcelin, Maria Angeles Munoz, Annalisa Dalzini, Raffaella Petrara, Kathleen Gartner, Lesley De Armas, Pahwa Rajendra, Suresh Pallikkuth, Deborah Persaud, Nicolas Chomont, Mathias Lichterfeld, Silvia Faggion, Daniel Gomez Pena, Andrea Oletto, Alessandra Nardone, Paola Zangari, Silvia Di Cesare, Chiara Medri, Olga Kolesova, Carla Paganin, William James, Inger Lindfors - Rossi, Shrabon Samiur Hassan, Francesca Mazzetto, Hellen Akisinku, Musakanya Chingandu, Francesca Rocchi, Ilaria Pepponi, Rob J. De Boer, Juliane Schroter, Viviana Giannuzzi, Sinead Morris

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

BackgroundDespite a successful antiretroviral therapy (ART), adolescents living with perinatally acquired HIV (PHIV) experience signs of B-cell hyperactivation with expansion of ‘namely’ atypical B-cell phenotypes, including double negative (CD27

Externí odkaz: https://doaj.org/article/4c3438cc6e094cf89b7fa756b480c8ba

Insights from Clonal Expansion and HIV Persistence in Perinatal Infections

Autor: Adit Dhummakupt, Deborah Persaud

Publikováno v: mBio, Vol 12, Iss 4 (2021)

ABSTRACT The latent HIV reservoir forms early in the course of infection and is maintained for life despite effective antiretroviral treatment (ART), including early treatment. Perinatal HIV infection presents a unique opportunity to limit seeding of

Externí odkaz: https://doaj.org/article/3113ca5c608a44f593f50e56723e67a3

Paucity of Intact Non-Induced Provirus with Early, Long-Term Antiretroviral Therapy of Perinatal HIV Infection.

Autor: Kaitlin Rainwater-Lovett, Carrie Ziemniak, Douglas Watson, Katherine Luzuriaga, George Siberry, Ann Petru, YaHui Chen, Priyanka Uprety, Margaret McManus, Ya-Chi Ho, Susanna L Lamers, Deborah Persaud

Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0170548 (2017)

The latent reservoir is a major barrier to HIV eradication. Reservoir size is emerging as an important biomarker to assess the likelihood of HIV remission in the absence of antiretroviral therapy (ART) and may be reduced by earlier initiation of ART

Externí odkaz: https://doaj.org/article/608b954791e54b9a822fa6c2f46b03d5