Výsledky vyhledávání - "Deborah Peana"

Arrhythmogenesis in the aged heart following ischaemia–reperfusion: role of transient receptor potential vanilloid 4

Autor: Luis Polo-Parada, Deborah Peana, Timothy L. Domeier

Publikováno v: Cardiovascular Research. 118:1126-1137

Aims Cardiomyocyte Ca2+ homoeostasis is altered with ageing and predisposes the heart to Ca2+ intolerance and arrhythmia. Transient receptor potential vanilloid 4 (TRPV4) is an osmotically activated cation channel with expression in cardiomyocytes of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9f815dd3a9b2f21c49026eb48d5821
https://doi.org/10.1093/cvr/cvab141

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TRPV4 Contributes to Pro-arrhythmic Calcium Signaling in Cardiomyocytes of Aged Mice

Autor: Timothy L. Domeier, Deborah Peana

Publikováno v: Biophysical Journal. 118:34a-35a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d01c2d1be4353bfcd6b6ef7ee8d9dca
https://doi.org/10.1016/j.bpj.2019.11.367

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Transient receptor potential vanilloid-4 contributes to stretch-induced hypercontractility and time-dependent dysfunction in the aged heart

Autor: Michelle D. Lambert, Timothy L. Domeier, Kerry S. McDonald, Adam B. Veteto, Deborah Peana

Publikováno v: Cardiovasc Res

Aims Cardiovascular disease remains the greatest cause of mortality in Americans over 65. The stretch-activated transient receptor potential vanilloid-4 (TRPV4) ion channel is expressed in cardiomyocytes of the aged heart. This investigation tests th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd08636a3487d378ebf9694cb0d22d33
https://europepmc.org/articles/PMC7449559/

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TRPV4 increases cardiomyocyte calcium cycling and contractility yet contributes to damage in the aged heart following hypoosmotic stress

Autor: Michael A. Hill, Natalia G. Karasseva, Michelle D. Lambert, Brian R. Lindman, Timothy L. Domeier, Deborah Peana, Maike Krenz, Zahra Nourian, Christopher P. Baines, John L. Jones, Adam B. Veteto

AimsCardiomyocyte Ca2+ homeostasis is altered with aging via poorly-understood mechanisms. The Transient Receptor Potential Vanilloid 4 (TRPV4) ion channel is an osmotically-activated Ca2+ channel, and there is limited information on the role of TRPV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2265e6ea56de99bbe04ec03087ffbe0b
https://europepmc.org/articles/PMC6302264/

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Cardiomyocyte Ca2+ homeostasis as a therapeutic target in heart failure with reduced and preserved ejection fraction

Autor: Deborah Peana, Timothy L. Domeier

Heart failure is a highly prevalent syndrome of multiple etiologies and associated comorbidities, and aberrant intracellular Ca2+ homeostasis is a hallmark finding in heart failure patients. The cyclical changes in Ca2+ concentration within cardiomyo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4f15905ec0b4ed8114aead03ec9889
https://europepmc.org/articles/PMC5567788/

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TRPV4 Enhances Cardiomyocyte Calcium Transients and Cardiac Contractility Following Hypoosmotic Stress and Ischemia-Reperfusion

Autor: Deborah Peana, Timothy L. Domeier, John L. Jones, Michelle D. Lambert

Publikováno v: Biophysical Journal. 112:95a-96a

The Transient Receptor Potential (TRP) ion channel family plays an important role in cardiomyocyte calcium homeostasis, particularly in diseased states. Here, we test the hypothesis that the osmotically-activated TRP Vanilloid 4 (TRPV4) channel enhan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3eeb3332cee59ad44bfb793ef5669a04
https://doi.org/10.1016/j.bpj.2016.11.556

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