Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Deborah P. French"'
Publikováno v:
Frontiers in Environmental Science, Vol 10 (2022)
Water-in-oil emulsification affects spilled oil fate and exposure, as well as the effectiveness of oil spill response options, via changes in oil viscosity. While oil weathering processes such as evaporation, dissolution, photo-oxidation, and biodegr
Externí odkaz:
https://doaj.org/article/ca0e4f99f6f644568b13f3b4d5525211
Autor:
Deborah P. French-McCay, Malcolm L. Spaulding, Deborah Crowley, Daniel Mendelsohn, Jeremy Fontenault, Matthew Horn
Publikováno v:
Frontiers in Marine Science, Vol 8 (2021)
Trajectory and fate modeling of the oil released during the Deepwater Horizon blowout was performed for April to September of 2010 using a variety of input data sets, including combinations of seven hydrodynamic and four wind models, to determine the
Externí odkaz:
https://doaj.org/article/01a19019a53345c58b3744e0ac5ca588
Autor:
Deborah P. French-McCay, Tayebeh Tajalli-Bakhsh, Kathy Jayko, Malcolm L. Spaulding, Zhengkai Li
Publikováno v:
Arctic Science, Vol 4, Iss 1, Pp 71-97 (2018)
Reliability of oil spill modeling in Arctic waters for response planning and risk assessments depends on the accuracy of winds, currents, and ice data (cover and drift) used as input. We compared predicted transport in ice, using ice and ocean model
Externí odkaz:
https://doaj.org/article/f1b42e142a484cce9276d395d8dffda5
Autor:
Clyde A. Campbell, Rodolfo Calderon, Giulia Pavani, Xiaoyi Cheng, Radwa Barakat, Elizabeth Snella, Fang Liu, Xiyu Peng, Jeffrey J. Essner, Karin S. Dorman, Maura McGrail, Paul Gadue, Deborah L. French, Raquel Espin-Palazon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Most gene functions have been discovered through phenotypic observations under loss of function experiments that lack temporal control. However, cell signaling relies on limited transcriptional effectors, having to be re-used temporally and
Externí odkaz:
https://doaj.org/article/3dcd259cad5344e190f688aa08345ae0
Autor:
Karla F. Leavens, Catherine Osorio-Quintero, Elisabeth Ashlyne Yeuteuh, Francesca T. Perez-Profeta, Anna Ada Dattoli, Fabian L. Cardenas-Diaz, Deborah L. French, Paul Gadue
Publikováno v:
Stem Cell Research, Vol 81, Iss , Pp 103559- (2024)
Over the past decade, the use of human stem cell-derived β cells (SC-β cells) to model pancreatic β cell development, function and disease has become increasingly common. Though protocols are rapidly improving, current directed differentiation str
Externí odkaz:
https://doaj.org/article/7e9dd37f13724c6c96ca51f2e1be1d9f
Autor:
Xiaoyi Cheng, Radwa Barakat, Giulia Pavani, Masuma Khatun Usha, Rodolfo Calderon, Elizabeth Snella, Abigail Gorden, Yudi Zhang, Paul Gadue, Deborah L. French, Karin S. Dorman, Antonella Fidanza, Clyde A. Campbell, Raquel Espin-Palazon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Uncovering the mechanisms regulating hematopoietic specification not only would overcome current limitations related to hematopoietic stem and progenitor cell (HSPC) transplantation, but also advance cellular immunotherapies. However, genera
Externí odkaz:
https://doaj.org/article/c2136f3074024e3ca14b63136730c55e
Autor:
Carolina Gracia-Diaz, Yijing Zhou, Qian Yang, Reza Maroofian, Paula Espana-Bonilla, Chul-Hwan Lee, Shuo Zhang, Natàlia Padilla, Raquel Fueyo, Elisa A. Waxman, Sunyimeng Lei, Garrett Otrimski, Dong Li, Sarah E. Sheppard, Paul Mark, Margaret H. Harr, Hakon Hakonarson, Lance Rodan, Adam Jackson, Pradeep Vasudevan, Corrina Powel, Shehla Mohammed, Sateesh Maddirevula, Hamad Alzaidan, Eissa A. Faqeih, Stephanie Efthymiou, Valentina Turchetti, Fatima Rahman, Shazia Maqbool, Vincenzo Salpietro, Shahnaz H. Ibrahim, Gabriella di Rosa, Henry Houlden, Maha Nasser Alharbi, Nouriya Abbas Al-Sannaa, Peter Bauer, Giovanni Zifarelli, Conchi Estaras, Anna C. E. Hurst, Michelle L. Thompson, Anna Chassevent, Constance L. Smith-Hicks, Xavier de la Cruz, Alexander M. Holtz, Houda Zghal Elloumi, M J Hajianpour, Claudine Rieubland, Dominique Braun, Siddharth Banka, Genomic England Research Consortium, Deborah L. French, Elizabeth A. Heller, Murielle Saade, Hongjun Song, Guo-li Ming, Fowzan S. Alkuraya, Pankaj B. Agrawal, Danny Reinberg, Elizabeth J. Bhoj, Marian A. Martínez-Balbás, Naiara Akizu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Genetic variants in chromatin regulators are frequently found in neurodevelopmental disorders, but their effect in disease etiology is rarely determined. Here, we uncover and functionally define pathogenic variants in the chromatin modifier
Externí odkaz:
https://doaj.org/article/78105606e072432f9749da08dbbd20b7
Autor:
Astrid Wintering, Anna Hecht, Julia Meyer, Eric B. Wong, Juwita Hübner, Sydney Abelson, Kira Feldman, Vanessa E. Kennedy, Cheryl A.C. Peretz, Deborah L. French, Jean Ann Maguire, Chintan Jobaliya, Marta Rojas Vasquez, Sunil Desai, Robin Dulman, Eneida Nemecek, Hilary Haines, Mahmoud Hammad, Alaa El Haddad, Scott C. Kogan, Zied Abdullaev, Farid F. Chehab, Sarah K. Tasian, Catherine C. Smith, Mignon L. Loh, Elliot Stieglitz
Publikováno v:
Haematologica, Vol 999, Iss 1 (2023)
Mutations in five canonical Ras pathway genes (NF1, NRAS, KRAS, PTPN11 and CBL) are detected in nearly 90% of patients with juvenile myelomonocytic leukemia (JMML), a frequently fatal malignant neoplasm of early childhood. In this report, we describe
Externí odkaz:
https://doaj.org/article/6b7a3df1a4054f309e85875af70a1441
Mapping PTBP2 binding in human brain identifies SYNGAP1 as a target for therapeutic splice switching
Autor:
Jennine M. Dawicki-McKenna, Alex J. Felix, Elisa A. Waxman, Congsheng Cheng, Defne A. Amado, Paul T. Ranum, Alexey Bogush, Lea V. Dungan, Jean Ann Maguire, Alyssa L. Gagne, Elizabeth A. Heller, Deborah L. French, Beverly L. Davidson, Benjamin L. Prosser
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Alternative splicing of neuronal genes is controlled partly by the coordinated action of polypyrimidine tract binding proteins (PTBPs). While PTBP1 is ubiquitously expressed, PTBP2 is predominantly neuronal. Here, we define the PTBP2 footpri
Externí odkaz:
https://doaj.org/article/8fbfb46edfea4a479ef94d2853340d5a
Publikováno v:
Stem Cell Research, Vol 72, Iss , Pp 103198- (2023)
Transient myeloproliferative disorder (TMD) is a pre-leukemic condition that occurs only in neonates with Trisomy 21 (T21), and is attributed to a genetic interaction between the third copy of chromosome 21 (HSA21) and a mutation in the transcription
Externí odkaz:
https://doaj.org/article/f8c9135c166d4e149878ad04c97721c5