Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Deborah Noack"'
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4755 (2009)
Bacillus anthracis lethal toxin (LT) is a key virulence factor of anthrax and contributes significantly to the in vivo pathology. The enzymatically active component is a Zn(2+)-dependent metalloprotease that cleaves most isoforms of mitogen-activated
Externí odkaz:
https://doaj.org/article/c89d6ff88b9545a2a3f2450e326a720b
Publikováno v:
Molecular and Cellular Biology. 30:961-975
Regulated generation of reactive oxygen species (ROS) is primarily accomplished by NADPH oxidases (Nox). Nox1 to Nox4 form a membrane-associated heterodimer with p22(phox), creating the docking site for assembly of the activated oxidase. Signaling sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f89e51afce99c044785a6d9b6fedfd
https://doi.org/10.1128/mcb.01393-09
https://doi.org/10.1128/mcb.01393-09
Publikováno v:
Journal of Biological Chemistry. 283:35273-35282
The integral membrane protein p22phox forms a heterodimeric enzyme complex with NADPH oxidases (Noxs) and is required for their catalytic activity. Nox4, a Nox linked to cardiovascular disease, angiogenesis, and insulin signaling, is unique in its ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5226fb3d6aaaafad396dc08908f15391
https://doi.org/10.1074/jbc.m804200200
https://doi.org/10.1074/jbc.m804200200
Publikováno v:
Blood. 100:1845-1851
The p47-phox gene, NCF-1, has 2 nearly identical pseudogenes (psiNCF-1) in proximity at chromosomal locus 7q11.23. A dinucleotide deletion (DeltaGT) at the beginning of exon 2 that leads to a frameshift and premature stop codon is considered the sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c03808d0dd2bdeba7f3522d1b884389
https://doi.org/10.1182/blood-2002-03-0861
https://doi.org/10.1182/blood-2002-03-0861
Autor:
Ching Chuan Liu, Deborah Noack, Shio Jean Lin, Bor-Luen Chiang, Chi Chang Shieh, Ching Yuan Lin, Chin Mu Yang, Paul G. Heyworth, Ya Fang Huang, Ji Yao Wang, Jing Yi Chen
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1586:275-286
Chronic granulomatous disease (CGD) is an inherited immunodeficiency disease caused by defects in leukocyte NADPH oxidase. Various inherited defects in one of the membrane-bound components of NADPH oxidase, gp91-phox, cause X-linked (X91) CGD. Analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485f703603f5f9b6df0db1ee0be8f8f4
https://doi.org/10.1016/s0925-4439(01)00106-5
https://doi.org/10.1016/s0925-4439(01)00106-5
Publikováno v:
Human Genetics. 109:234-238
The most common form of chronic granulomatous disease (CGD) is caused by mutations in the CYBB gene that is carried on the X-chromosome and give rise to the X-linked form of the disease. The product of this gene is the large subunit of flavocytochrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b5e244e3caec746a36cf62c557ed79
https://doi.org/10.1007/s004390100551
https://doi.org/10.1007/s004390100551
Autor:
Beverly A. Ellis, Andrew R. Cross, Julie Rae, John T. Curnutte, Paul G. Heyworth, Peter E. Newburger, Deborah Noack
Publikováno v:
Blood. 97:305-311
Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defects in any one of 4 genes encoding phagocyte NADPH oxidase subunits. Unlike other CGD subtypes, in which there is great heterogeneity among mutations, 97% of affected all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49622731fb2ee24517541c70bb856856
https://doi.org/10.1182/blood.v97.1.305
https://doi.org/10.1182/blood.v97.1.305
Publikováno v:
Blood Cells, Molecules, and Diseases. 26:561-565
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a3fdd90af90cc412f92ecd14fd9e03
https://doi.org/10.1006/bcmd.2000.0333
https://doi.org/10.1006/bcmd.2000.0333
Autor:
Andrew R. Cross, John T. Curnutte, Beverly A. Ellis, Paul G. Heyworth, Julie Rae, Deborah Noack
Publikováno v:
Blood. 96:1106-1112
Chronic granulomatous disease is a rare inherited disorder caused by nonexistent or severely decreased phagocyte superoxide production that results in a severe defect in host defense and consequent predisposition to microbial infection. The enzyme re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b793c7e88f9a24794398a32415976f5a
https://doi.org/10.1182/blood.v96.3.1106
https://doi.org/10.1182/blood.v96.3.1106
Autor:
Julie Rae, Deborah Noack, Paul G. Heyworth, Beverly A. Ellis, John T. Curnutte, Andrew R. Cross
Publikováno v:
Blood. 96:1106-1112
Chronic granulomatous disease is a rare inherited disorder caused by nonexistent or severely decreased phagocyte superoxide production that results in a severe defect in host defense and consequent predisposition to microbial infection. The enzyme re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::704a1f4ae21b8d5b9b3e3bf3567a7913
https://doi.org/10.1182/blood.v96.3.1106.015k44_1106_1112
https://doi.org/10.1182/blood.v96.3.1106.015k44_1106_1112