Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Deborah Moorad-Doctor"'
Autor:
Bryan J. McCranor, Melissa A. Olert, Deborah Moorad-Doctor, Catherine A. Hofstetter, Gregory E. Garcia, Douglas M. Cerasoli
Publikováno v:
Chemico-biological interactions. 259
To develop a prophylactic for organophosphorus (OP) poisoning utilizing catalytic bioscavengers, the circulatory stability of the enzymes needs to be increased. One strategy for increasing the bioavailability of OP bioscavengers is to target them to
Autor:
Andres Castillo, Deborah Moorad-Doctor, Ruthie H Ratcliffe, Gregory E. Garcia, Harry Singh, Katie Wachtel
Publikováno v:
Journal of Analytical Toxicology. 31:69-74
A rapid and sensitive assay for pyridinium oximes in plasma and tissue was developed. The method was suitable for the analysis of mono- and di-pyridinium oximes and utilizes ultrafiltration followed by cation-exchange high-performance liquid chromato
Publikováno v:
Chemico-biological interactions. 187(1-3)
The US Army utilizes pralidoxime (2-PAM) for the reactivation of OP-inhibited AChE. While 2-PAM effectively reactivates acetylcholinesterase (AChE) in the body, it does not cross the blood–brain barrier (BBB) at therapeutically relevant levels. To
Publikováno v:
The FASEB Journal. 23
Publikováno v:
The FASEB Journal. 23
Publikováno v:
The FASEB Journal. 23
Autor:
Deborah Moorad-Doctor, Mark L. Jewell, Ruthie H Ratcliffe, LaTawnya Y. Askins, John H. Carra, Harry Singh, Richard K. Gordon, Diane M. Calinski, Julie J. Ha, Gregory E. Garcia
Publikováno v:
The FASEB Journal. 20
Autor:
Haresh S. Ved, Rickey P. Hicks, Bhupendra P. Doctor, David J. Skanchy, Deborah Moorad-Doctor, Gregory E. Garcia
Publikováno v:
Journal of analytical toxicology. 28(5)
Huperzine A (Hup A) is under investigation as a treatment of Alzheimer's disease because of its properties of reversible and specific AChE inhibition. It has additional interesting pharmacological effects such as the protection of primary neuronal ce