Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Deborah Mai"'
Autor:
Amit Singh, David K Crossman, Deborah Mai, Loni Guidry, Martin I Voskuil, Matthew B Renfrow, Adrie J C Steyn
Publikováno v:
PLoS Pathogens, Vol 5, Iss 8, p e1000545 (2009)
The metabolic events associated with maintaining redox homeostasis in Mycobacterium tuberculosis (Mtb) during infection are poorly understood. Here, we discovered a novel redox switching mechanism by which Mtb WhiB3 under defined oxidizing and reduci
Externí odkaz:
https://doaj.org/article/bd5a30f329df4ff6bfce98bb7332f434
Autor:
Megan Lyon, Deborah Maiese, Rhonda West, Marci Sontag, Vivian Pan, Cinthya Zepeda Mendoza, Joann Bodurtha
Publikováno v:
Genetics in Medicine Open, Vol 2, Iss , Pp 101398- (2024)
Externí odkaz:
https://doaj.org/article/17991cadf73f4107ad18c14f6f983b55
Autor:
Laura Jean Bierut, Tabitha P. Hendershot, Neal L. Benowitz, K. Michael Cummings, Robin J. Mermelstein, Megan E. Piper, Scott I. Vrieze, Theodore L. Wagener, Mark D. Nelms, Cataia Ives, Deborah Maiese, Carol M. Hamilton, Gary E. Swan
Publikováno v:
Addiction Neuroscience, Vol 7, Iss , Pp 100081- (2023)
The use of standard protocols in studies supports consistent data collection, improves data quality, and facilitates cross-study analyses. Funded by the National Institutes of Health, the PhenX (consensus measures for Phenotypes and eXposures) Toolki
Externí odkaz:
https://doaj.org/article/3c0a6b71090842e78d90c672e506eb01
Autor:
Deborah Mai, John W. Rodgers, Olaf Kutsch, John L. Hartman, Jennifer Jones, Adrie J. C. Steyn
Publikováno v:
ASSAY and Drug Development Technologies. 9:299-310
Despite extensive efforts in tuberculosis (TB) drug research, very few novel inhibitors have been discovered. This issue emphasizes the need for innovative methods to discover new anti-TB drugs. In this study, we established a new high-throughput scr
Autor:
Alexander J. Ropelewski, Megan A. Rizzo, Jason R. Swedlow, Jan Huisken, Pavel Osten, Neda Khanjani, Kurt Weiss, Vesselina Bakalov, Michelle Engle, Lauren Gridley, Michelle Krzyzanowski, Tom Madden, Deborah Maiese, Meisha Mandal, Justin Waterfield, David Williams, Carol M. Hamilton, Wayne Huggins
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-8 (2022)
Abstract Recent advances in fluorescence microscopy techniques and tissue clearing, labeling, and staining provide unprecedented opportunities to investigate brain structure and function. These experiments’ images make it possible to catalog brain
Externí odkaz:
https://doaj.org/article/3d9ee52d708f418a9656854eb7dbcc34
Autor:
Gregory I. Giles, Amit Singh, Loni Guidry, K. V. Narasimhulu, Deborah Mai, Jack R. Lancaster, Kevin Redding, John E. Trombley, Adrie J. C. Steyn
Publikováno v:
Proceedings of the National Academy of Sciences. 104:11562-11567
A fundamental challenge in the redox biology of Mycobacterium tuberculosis ( Mtb ) is to understand the mechanisms involved in sensing redox signals such as oxygen (O 2 ), nitric oxide (NO), and nutrient depletion, which are thought to play a crucial
Publikováno v:
Proceedings of the National Academy of Sciences. 103:11346-11351
The sudden increase in information derived from the completed Mycobacterium tuberculosis ( Mtb ) genome sequences has revealed the need for approaches capable of converting raw genome sequence data into functional information. To date, an experimenta
Publikováno v:
Genetics in Medicine Open, Vol 1, Iss 1, Pp 100762- (2023)
Externí odkaz:
https://doaj.org/article/d22a7b339b284ddfba83020719429fe3
Publikováno v:
Systems Biology of Tuberculosis ISBN: 9781461449652
An important challenge for TB investigators in the postgenomic era is to integrate distinct functional strategies to study the molecular mechanism of Mycobacterium tuberculosis (Mtb) virulence. However, the biological function of the majority of Mtb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c642d2d46c3d1eda4c0655cd24d1a7fe
https://doi.org/10.1007/978-1-4614-4966-9_5
https://doi.org/10.1007/978-1-4614-4966-9_5
Autor:
Mansi Mehta, Kevin Redding, Nimi Vashi, Manbeena Chawla, Pankti Parikh, Anup Srivastava, Amit Singh, Adrie J. C. Steyn, Dhiraj Kumar, MohamedHusen Munshi, K. V. Narasimhulu, Alka Saxena, Deborah Mai
Publikováno v:
Molecular Microbiology
Host-generated oxidative stress is considered one of the main mechanisms constraining Mycobacterium tuberculosis (Mtb) growth. The redox-sensing mechanisms in Mtb are not completely understood. Here we show that WhiB4 responds to oxygen (O2) and nitr