Zobrazeno 1 - 10
of 245
pro vyhledávání: '"Deborah M Muoio"'
Autor:
Tsunehisa Yamamoto, Santosh K. Maurya, Elizabeth Pruzinsky, Kirill Batmanov, Yang Xiao, Sarah M. Sulon, Tomoya Sakamoto, Yang Wang, Ling Lai, Kendra S. McDaid, Swapnil V. Shewale, Teresa C. Leone, Timothy R. Koves, Deborah M. Muoio, Pieterjan Dierickx, Mitchell A. Lazar, E. Douglas Lewandowski, Daniel P. Kelly
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
During the development of heart failure (HF), the capacity for cardiomyocyte (CM) fatty acid oxidation (FAO) and ATP production is progressively diminished, contributing to pathologic cardiac hypertrophy and contractile dysfunction. Receptor-interact
Externí odkaz:
https://doaj.org/article/73b6b8d5e2734d2b968b0ca4b0b2ae53
Autor:
Adilson Guilherme, Leslie A. Rowland, Nicole Wetoska, Emmanouela Tsagkaraki, Kaltinaitis B. Santos, Alexander H. Bedard, Felipe Henriques, Mark Kelly, Sean Munroe, David J. Pedersen, Olga R. Ilkayeva, Timothy R. Koves, Lauren Tauer, Meixia Pan, Xianlin Han, Jason K. Kim, Christopher B. Newgard, Deborah M. Muoio, Michael P. Czech
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112488- (2023)
Summary: Disruption of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) in mice induces browning in inguinal white adipose tissue (iWAT). However, adipocyte FASN knockout (KO) increases acetyl-coenzyme A (CoA) and malonyl
Externí odkaz:
https://doaj.org/article/12bc2d6551c14f2b8d253e56cdc46fc0
Autor:
Brian J. Andonian, Alec Koss, Timothy R. Koves, Elizabeth R. Hauser, Monica J. Hubal, David M. Pober, Janet M. Lord, Nancie J. MacIver, E. William St Clair, Deborah M. Muoio, William E. Kraus, David B. Bartlett, Kim M. Huffman
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Rheumatoid arthritis (RA) T cells drive autoimmune features via metabolic reprogramming that reduces oxidative metabolism. Exercise training improves cardiorespiratory fitness (i.e., systemic oxidative metabolism) and thus may impact RA T ce
Externí odkaz:
https://doaj.org/article/d278494452384d9c98c274272259150e
Autor:
Rodrigo F. Mancilla, Lucas Lindeboom, Lotte Grevendonk, Joris Hoeks, Tim R. Koves, Deborah M. Muoio, Patrick Schrauwen, Vera Schrauwen-Hinderling, Matthijs K.C. Hesselink
Publikováno v:
JCI Insight, Vol 8, Iss 1 (2023)
BACKGROUND At the onset of exercise, the speed at which phosphocreatine (PCr) decreases toward a new steady state (PCr on-kinetics) reflects the readiness to activate mitochondrial ATP synthesis, which is secondary to Acetyl-CoA availability in skele
Externí odkaz:
https://doaj.org/article/8e326707d1094bde815ebc4daea2ec00
Autor:
Yvo J.M. op den Kamp, Anne Gemmink, Marlies de Ligt, Bas Dautzenberg, Esther Kornips, Johanna A. Jorgensen, Gert Schaart, Russell Esterline, Diego A. Pava, Joris Hoeks, Vera B. Schrauwen-Hinderling, Sander Kersten, Bas Havekes, Timothy R. Koves, Deborah M. Muoio, Matthijs K.C. Hesselink, Jan Oscarsson, Esther Phielix, Patrick Schrauwen
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101620- (2022)
Objective: SGLT2 inhibitors increase urinary glucose excretion and have beneficial effects on cardiovascular and renal outcomes; the underlying mechanism may be metabolic adaptations due to urinary glucose loss. Here, we investigated the cellular and
Externí odkaz:
https://doaj.org/article/ce94ee3f45bd45f3ad7d1120c2287583
Autor:
Maria J. Torres, Xu Zhang, Dorothy H. Slentz, Timothy R. Koves, Hailee Patel, George A. Truskey, Deborah M. Muoio
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105189- (2022)
Summary: Two prominent frontline breast cancer (BC) chemotherapies commonly used in combination, doxorubicin (DOX) and docetaxel (TAX), are associated with long-lasting cardiometabolic and musculoskeletal side effects. Whereas DOX has been linked to
Externí odkaz:
https://doaj.org/article/c8925c5ae8554c5e8f3c1c0d1e770e8d
Publikováno v:
Data in Brief, Vol 42, Iss , Pp 108051- (2022)
STIM1 is an ER/SR transmembrane protein that interacts with ORAI1 to activate store operated Ca2+ entry (SOCE) upon ER/SR depletion of calcium. Normally highly expressed in skeletal muscle, STIM1 deficiency causes significant changes to mitochondrial
Externí odkaz:
https://doaj.org/article/d125f6344da6454d846204e94267e8bf
Autor:
Rebecca J. Wilson, Scott P. Lyons, Timothy R. Koves, Victoria G. Bryson, Hengtao Zhang, TianYu Li, Scott B. Crown, Jin-Dong Ding, Paul A. Grimsrud, Paul B. Rosenberg, Deborah M. Muoio
Publikováno v:
Molecular Metabolism, Vol 57, Iss , Pp 101429- (2022)
Objective: Stromal interaction molecule 1 (STIM1) is a single-pass transmembrane endoplasmic/sarcoplasmic reticulum (E/SR) protein recognized for its role in a store operated Ca2+ entry (SOCE), an ancient and ubiquitous signaling pathway. Whereas STI
Externí odkaz:
https://doaj.org/article/64af5c6488244928abf80bd0658ef3e5
Autor:
Ashley S. Williams, Timothy R. Koves, Yasminye D. Pettway, James A. Draper, Dorothy H. Slentz, Paul A. Grimsrud, Olga R. Ilkayeva, Deborah M. Muoio
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103635- (2022)
Summary: Nicotinamide riboside supplements (NRS) have been touted as a nutraceutical that promotes cardiometabolic and musculoskeletal health by enhancing nicotinamide adenine dinucleotide (NAD+) biosynthesis, mitochondrial function, and/or the activ
Externí odkaz:
https://doaj.org/article/613c482ce3f74ec8b3a7c71691a2c885
Autor:
Hengtao Zhang, Victoria Graham Bryson, Chaojian Wang, TianYu Li, Jaclyn P. Kerr, Rebecca Wilson, Deborah M. Muoio, Robert J. Bloch, Christopher Ward, Paul B. Rosenberg
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
Stromal interaction molecule 1 (STIM1), the sarcoplasmic reticulum (SR) transmembrane protein, activates store-operated Ca2+ entry (SOCE) in skeletal muscle and, thereby, coordinates Ca2+ homeostasis, Ca2+-dependent gene expression, and contractility
Externí odkaz:
https://doaj.org/article/4ef5dfde9ee943f784bb8eee0d805e3a