Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Deborah M Eaton"'
Autor:
Yijun Yang, Jaslyn Johnson, Constantine D. Troupes, Eric A. Feldsott, Lindsay Kraus, Emily Megill, Zilin Bian, Ngefor Asangwe, Tabito Kino, Deborah M. Eaton, Tao Wang, Marcus Wagner, Lena Ma, Christopher Bryan, Markus Wallner, Hajime Kubo, Remus M. Berretta, Mohsin Khan, Hong Wang, Raj Kishore, Steven R. Houser, Sadia Mohsin
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102909- (2023)
Few therapies have produced significant improvement in cardiac structure and function after ischemic cardiac injury (ICI). Our possible explanation is activation of local inflammatory responses negatively impact the cardiac repair process following i
Externí odkaz:
https://doaj.org/article/f68a1e3939344780bdcabe697059e9a3
Autor:
Deborah M. Eaton, Thomas G. Martin, Michael Kasa, Natasa Djalinac, Senka Ljubojevic-Holzer, Dirk Von Lewinski, Maria Pöttler, Theerachat Kampaengsri, Andreas Krumphuber, Katharina Scharer, Heinrich Maechler, Andreas Zirlik, Timothy A. McKinsey, Jonathan A. Kirk, Steven R. Houser, Peter P. Rainer, Markus Wallner
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1509 (2022)
We recently established a large animal model that recapitulates key clinical features of heart failure with preserved ejection fraction (HFpEF) and tested the effects of the pan-HDAC inhibitor suberoylanilide hydroxamic acid (SAHA). SAHA reversed and
Externí odkaz:
https://doaj.org/article/8202b47d0850427680ff0cf1c88c361a
Autor:
Jaslyn Johnson, Yijun Yang, Zilin Bian, Giana Schena, Yijia Li, Xiaoying Zhang, Deborah M. Eaton, Polina Gross, Alexandra Angheloiu, Arshadullah Shaik, Michael Foster, Remus Berretta, Hajime Kubo, Sadia Mohsin, Ying Tian, Steven R. Houser
Publikováno v:
Circulation Research. 132:723-740
Background: A recent study suggests that systemic hypoxemia in adult male mice can induce cardiac myocytes to proliferate. The goal of the present experiments was to confirm these results, provide new insights on the mechanisms that induce adult card
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::907e04d9dfe2695558d41f5ca0788a77
https://doi.org/10.1161/circresaha.122.321604
https://doi.org/10.1161/circresaha.122.321604
Publikováno v:
JACC: Case Reports, Vol 3, Iss 1, Pp 39-40 (2021)
Externí odkaz:
https://doaj.org/article/64f12d8fb48a4a64863cd6a7b06981de
Autor:
Alaina L. Headrick, Jaslyn Johnson, Timothy A. McKinsey, Giana Schena, Yijun Yang, Sadia Mohsin, Deborah M Eaton, Raj Kishore, Keith A. Koch, John W. Elrod, Steven R. Houser, Hajime Kubo, Remus M. Berretta, Alycia N Hildebrand, Emma K Murray
Publikováno v:
Am J Physiol Heart Circ Physiol
Heart failure is the one of the leading causes of death in the United States. Heart failure is a complex syndrome caused by numerous diseases, including severe myocardial infarction (MI). MI occurs after an occlusion of a cardiac artery causing downs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876566a6f6474635de6efedc48a6a574
https://doi.org/10.1152/ajpheart.00197.2021
https://doi.org/10.1152/ajpheart.00197.2021
Autor:
Giulia Borghetti, Dirk von Lewinski, Deborah M. Eaton, Harald Sourij, Steven R. Houser, Markus Wallner
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Diabetes mellitus and the associated complications represent a global burden on human health and economics. Cardiovascular diseases are the leading cause of death in diabetic patients, who have a 2–5 times higher risk of developing heart failure th
Externí odkaz:
https://doaj.org/article/ba39eeab2fef447cacb327fc1923788f
Autor:
Deborah M. Eaton, Remus M. Berretta, Jacqueline E. Lynch, Joshua G. Travers, Ryan D. Pfeiffer, Michelle L. Hulke, Huaqing Zhao, Alexander R. H. Hobby, Giana Schena, Jaslyn P. Johnson, Markus Wallner, Edward Lau, Maggie P. Y. Lam, Kathleen C. Woulfe, Nathan R. Tucker, Timothy A. McKinsey, Marla R. Wolfson, Steven R. Houser
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 323(4)
Approximately 50% of all heart failure (HF) diagnoses can be classified as HF with preserved ejection fraction (HFpEF). HFpEF is more prevalent in females compared with males, but the underlying mechanisms are unknown. We previously showed that press
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0533c0ec3093f75dbffdca87ff1e9495
https://pubmed.ncbi.nlm.nih.gov/36053749
https://pubmed.ncbi.nlm.nih.gov/36053749
Autor:
John W. Elrod, Steven R. Houser, Markus Wallner, Remus M. Berretta, Dhanendra Tomar, Anh T Huynh, Joanne F Garbincius, Deborah M Eaton, Emma K Murray, Devin W. Kolmetzky, Andrew A. Gibb
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • Early cardiac mitochondrial dysfunction is mediated by transcriptional down-regulation of the mitochondrial proteome. • Comprehensive metabolic remodeling is conserved throughout HFpEF progression and includes in
Highlights • Early cardiac mitochondrial dysfunction is mediated by transcriptional down-regulation of the mitochondrial proteome. • Comprehensive metabolic remodeling is conserved throughout HFpEF progression and includes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474acd63270db1077349e2d878112f6b
https://doi.org/10.1016/j.jacbts.2021.07.004
https://doi.org/10.1016/j.jacbts.2021.07.004
Autor:
Daohai Yu, Victor Rizzo, Xiongwen Chen, Jonathan P. Lambert, Markus Wallner, Abdelkarim Sabri, Jaslyn Johnson, Carlos Manuel Romero, Yijun Yang, Claire Poulet, Julia Gorelik, Andrew A. Gibb, Polina Gross, Jose L. Sanchez-Alonso, Joanne F Garbincius, Remus M. Berretta, John W. Elrod, Deborah M Eaton, Erdem Varol, Hajime Kubo, Carla Lucarelli, Jean Ross, Steven R. Houser, Eric Feldsott
Publikováno v:
Circulation Research. 128:92-114
Rationale: Ca 2+ -induced Ca 2+ release (CICR) in normal hearts requires close approximation of L-type calcium channels (LTCCs) within the transverse tubules (T-tubules) and RyR (ryanodine receptors) within the junctional sarcoplasmic reticulum. CICR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f26ec0029d7f615793680e9749ea350
https://doi.org/10.1161/circresaha.119.315715
https://doi.org/10.1161/circresaha.119.315715
Autor:
Deborah M Eaton, Thomas G Martin, Michael Kasa, Natasa Djalinac, Jaslyn P Johnson, Ewald Kolesnik, Senka Ljubojevic-Holzer, Dirk von Lewinski, Maria Poettler, Heinrich Maechler, Andreas Zirlik, Timothy A McKinsey, Jonathan A Kirk, Steven R Houser, Peter P Rainer, Markus Wallner
Publikováno v:
Circulation. 144
Introduction: Heart failure (HF) is a global issue and approximately 50% of patients are classified as having HF with preserved Ejection Fraction (HFpEF), with no FDA approved therapies available. We previously characterized a large animal model that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16fc9979b5e14aae2c4f6a84adc531fd
https://doi.org/10.1161/circ.144.suppl_1.10254
https://doi.org/10.1161/circ.144.suppl_1.10254