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pro vyhledávání: '"Deborah Lynette Jackson"'
Autor:
Richard L. Jarvest, Richard Stocker, John Andrew Corfield, S. Fernandes, Martin John Slater, C.D. Hartley, Onkar M. P. Singh, C. Wilkinson, V.L.H. Lovegrove, K.J. Medhurst, Malcolm Ellis, George Burton, Pia Thommes, Deborah Lynette Jackson, David Haigh, Nigel R. Parry, E.M. Amphlett, G. Bravi, Alan J. Wonacott, R. Guidetti, Helen Susanne Price, Anne Cheasty, R. Fenwick, P. Shah, David M. Andrews, Peter David Howes
Publikováno v:
Journal of medicinal chemistry. 50(5)
Optimization of a pyrrolidine-based template using structure-based design and physicochemical considerations has provided a development candidate 20b (3082) with submicromolar potency in the HCV replicon and good pharmacokinetic properties.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d53be85a2e2d11edeea984592657a4
https://pubmed.ncbi.nlm.nih.gov/17269759
https://pubmed.ncbi.nlm.nih.gov/17269759
