Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Deborah Lang"'
Autor:
Marc A. Vittoria, Nathan Kingston, Kristyna Kotynkova, Eric Xia, Rui Hong, Lee Huang, Shayna McDonald, Andrew Tilston-Lunel, Revati Darp, Joshua D. Campbell, Deborah Lang, Xiaowei Xu, Craig J. Ceol, Xaralabos Varelas, Neil J. Ganem
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Activating mutations of BRAF alone are inadequate to drive melanoma formation. Here the authors show that activation of Hippo signalling by oncogenic BRAF represents an additional safeguard to limit BRAF-dependent human melanocyte growth and melanoma
Externí odkaz:
https://doaj.org/article/f742ba331c9e4c36a7f1fe1c4bdef362
Autor:
Deborah Lang, Jag Bhawan, Candice Brem, Adil J. Haresi, Sixia Xiao, Elizabeth C. Little, Stephen P.G. Moore, Jason W. Lui, Jennifer La, Yougang Zhai, Lee Huang
Supplementary data and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e58d950cd92320d21e2fe8f276fc85
https://doi.org/10.1158/0008-5472.22425945.v1
https://doi.org/10.1158/0008-5472.22425945.v1
Autor:
Deborah Lang, Jag Bhawan, Candice Brem, Adil J. Haresi, Sixia Xiao, Elizabeth C. Little, Stephen P.G. Moore, Jason W. Lui, Jennifer La, Yougang Zhai, Lee Huang
The failure of once promising target-specific therapeutic strategies often arises from redundancies in gene expression pathways. Even with new melanoma treatments, many patients are not responsive or develop resistance, leading to disease progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c053a03864aad412562ba7b59ffe3a
https://doi.org/10.1158/0008-5472.c.6512190.v1
https://doi.org/10.1158/0008-5472.c.6512190.v1
Autor:
Deborah Lang, Jag Bhawan, Candice Brem, Adil J. Haresi, Sixia Xiao, Elizabeth C. Little, Stephen P.G. Moore, Jason W. Lui, Jennifer La, Yougang Zhai, Lee Huang
Supplementary figures S1, S2, and S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fcf14f05c2b3760889a26c097410d4e
https://doi.org/10.1158/0008-5472.22425942.v1
https://doi.org/10.1158/0008-5472.22425942.v1
Autor:
Deborah Lang Froggatt
Publikováno v:
Global Action for School Libraries ISBN: 9783110772586
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdfec145ed20d990bf7a72a90ded66f5
https://doi.org/10.1515/9783110772586-018
https://doi.org/10.1515/9783110772586-018
Autor:
Sixia Xiao, Jennifer La, Lee Huang, Stephen P.G. Moore, Jag Bhawan, Jason W Lui, Elizabeth C. Little, Deborah Lang, Candice E. Brem, Yougang Zhai, Adil J Haresi
Publikováno v:
Cancer Res
The failure of once promising target-specific therapeutic strategies often arises from redundancies in gene expression pathways. Even with new melanoma treatments, many patients are not responsive or develop resistance, leading to disease progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d8997dd53ae2ec8a70bd44a8111c0e
https://doi.org/10.1158/0008-5472.can-19-1668
https://doi.org/10.1158/0008-5472.can-19-1668
Publikováno v:
Journal of Biological Chemistry. 299:103400
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fdedfae6a38df81081abdf10434f6d4
https://doi.org/10.1016/j.jbc.2023.103400
https://doi.org/10.1016/j.jbc.2023.103400
Publikováno v:
Pigment Cell Melanoma Res
Yes Associated Protein 1 (YAP) and Transcriptional coactivator with PDZ-Binding Motif (TAZ) are transcriptional coactivators that have been implicated in driving metastasis and progression in many cancers, mainly through their transcriptional regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432489058ac7798d1e75f92eddffb90e
https://europepmc.org/articles/PMC8958630/
https://europepmc.org/articles/PMC8958630/
Autor:
Rui Hong, Shayna McDonald, Xiaowei Xu, Craig J. Ceol, Joshua D. Campbell, Andrew Tilston Lunel, Marc A. Vittoria, Xaralabos Varelas, Neil J. Ganem, Eric Xia, Lee Huang, Revati Darp, Nathan M Kingston, Deborah Lang
Human melanomas are commonly driven by activating mutations in BRAF, which promote melanocyte proliferation through constitutive stimulation of the MAPK pathway. However, oncogenic BRAF alone is insufficient to promote melanoma; instead, its expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdf851771f22317578da574a96f97929
https://doi.org/10.1101/2021.05.04.442615
https://doi.org/10.1101/2021.05.04.442615
Publikováno v:
Pigment Cell & Melanoma Research. 33:119-121
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0c37f7ddfec1621b0811f3c0eac42a5
https://doi.org/10.1111/pcmr.12821
https://doi.org/10.1111/pcmr.12821