Výsledky vyhledávání - "Deborah L. Widomski"

Effect of the Multitargeted Receptor Tyrosine Kinase Inhibitor, ABT-869 [N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N′-(2-fluoro-5-methylphenyl)urea], on Blood Pressure in Conscious Rats and Mice: Reversal with Antihypertensive Agents and Effect on Tumor Growth Inhibition

Autor: Bryan F. Cox, Steven K. Davidsen, Daniel H. Albert, William T. Noonan, Deborah L. Widomski, Paul Tapang, Gary A. Gintant, Pamela H. Franklin, Ryan M. Fryer, Jason A. Segreti, Patricia N. Banfor, Kelly J. Larson

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 329:928-937

ABT-869 [N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea] is a novel multitargeted inhibitor of the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor tyrosine kinase family members. AB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511ec23ea8a2a42e3086cda5b3ea3409
https://doi.org/10.1124/jpet.108.144816

Zobrazit plný text záznamu

A novel secretagogue increases cardiac contractility by enhancement of L-type Ca2+ current

Autor: Bryan F. Cox, James T. Limberis, Gary A. Gintant, Zhi Su, Xiaoqin Liu, Ruth L. Martin, Deborah L. Widomski, Jonathon Green, Gilbert Diaz

Publikováno v: Biochemical pharmacology. 80(7)

N′1-(3,3,6,8-tetramethyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yliden)-2-cyanoethanohydrazide (TTYC) increases secretion of glucagon-like peptide-1 and intracellular Ca 2+ concentration in GLUTag cells. The purpose of the present study was to examin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249fd590e68ca50eefe8e2ac4a9447d3
https://pubmed.ncbi.nlm.nih.gov/20599796

Zobrazit plný text záznamu

ETA receptor blockade with atrasentan prevents hypertension with the multitargeted tyrosine kinase inhibitor ABT-869 in telemetry-instrumented rats

Autor: Steven K. Davidsen, Ryan M. Fryer, Pamela A Franklin, Gary A. Gintant, Deborah L. Widomski, Bryan F. Cox, Daniel H. Albert, Jason A. Segreti, Patricia N. Banfor

Publikováno v: Journal of cardiovascular pharmacology. 53(2)

ABT-869 is a novel multitargeted inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinases (RTKs) with potent antiangiogenic properties that slow tumor progression. Vascular endothelial growth factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a26bbd77ec9ef5b0148a19685c0eb70d
https://pubmed.ncbi.nlm.nih.gov/19188829

Zobrazit plný text záznamu

Systemic activation of the calcium sensing receptor produces acute effects on vascular tone and circulatory function in uremic and normal rats: focus on central versus peripheral control of vascular tone and blood pressure by cinacalcet

Autor: Glenn A. Reinhart, Deborah L. Widomski, Kristin A. Koch, J. Ruth Wu-Wong, Pamela H. Franklin, Masaki Nakane, Ryan M. Fryer, Bryan F. Cox, Jason A. Segreti, Patricia N. Banfor

Publikováno v: The Journal of pharmacology and experimental therapeutics. 323(1)

Calcium-sensing receptor (CaR) activation decreases serum parathyroid hormone (PTH) and Ca2+ and, despite long-term reductions in mean arterial blood pressure (MAP), may produce acute hypertension in rats, an effect we hypothesized was mediated by co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff028adcf6680ff3a864931a2e2a7e9f
https://pubmed.ncbi.nlm.nih.gov/17636005

Zobrazit plný text záznamu

N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as acetyl-coA carboxylase inhibitors--improvement of cardiovascular and neurological liabilities via structural modifications

Publikováno v: Journal of medicinal chemistry. 50(5)

A preliminary safety evaluation of ACC2 inhibitor 1-(S) revealed serious neurological and cardiovascular liabilities of this chemotype. A systematic structure-toxicity relationship study identified the alkyne linker as the key motif responsible for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1688a54fd2d6e83db7ff5cfe8990bf69
https://pubmed.ncbi.nlm.nih.gov/17298049

Zobrazit plný text záznamu

Synthesis and biological characterization of L-N(6)-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor

Autor: Sofya Tsymbalov, Yan Zhang, Jane R. Connor, Mark G. Currie, Donald W. Hansen, Pamela T. Manning, Linda F. Branson, Clifford R. Dorn, Deborah L. Widomski, William M. Moore, Gina M. Jerome, Barnett S. Pitzele, E. Ann Hallinan

Publikováno v: Journal of medicinal chemistry. 45(8)

The 5-tetrazole amide of L-N(6)-(1-iminoethyl)lysine (L-NIL), L-N(6)-(1-iminoethyl)lysine 5-tetrazole amide (1), has been prepared and evaluated. In contrast to L-NIL, 1 is a stable, nonhygroscopic, crystalline solid. Unlike L-NIL, 1 has minimal inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599592a38db5f4fd3d6c6453848f3850
https://pubmed.ncbi.nlm.nih.gov/11931623

Zobrazit plný text záznamu

Akademický článek

N-3-2-(4-Alkoxyphenoxy)thiazol-5-yl-1-methylprop-2-ynylcarboxy Derivatives as Acetyl-CoA Carboxylase InhibitorsImprovement of Cardiovascular and Neurological Liabilities via Structural Modifications.

Publikováno v: Journal of Medicinal Chemistry; Mar2007, Vol. 50 Issue 5, p1078-1082, 5p

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání