Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Deborah L. Smith"'
Autor:
Akihiro Takano, Nahid Amini, Edmund J. Keliher, Christer Halldin, Lei Zhang, Richard E. Carson, Patrick Trapa, Sangram Nag, Ryosuke Arakawa, Deane M. Nason, Kevin P. Maresca, Zhisheng Jia, John Litchfield, Tarek A. Samad, Christopher Ryan Butler, Justin R. Piro, Timothy J. McCarthy, Deborah L. Smith, Steve O’Neil, Kari R. Fonseca
Background Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [11C]PF-06809247 into a clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b463c48140050426b0c96d37c2ff81
https://doi.org/10.21203/rs.3.rs-510615/v2
https://doi.org/10.21203/rs.3.rs-510615/v2
Autor:
Daniel P. Walker, Antonia F. Stepan, Mark A. Moen, Gregg D. Cappon, Christopher Houle, Annie C Won, Joshua R. Dunetz, Michael John Bohanon, Lei Zhang, Marc B. Skaddan, Patrick Robert Verhoest, Susan E. Drozda, Xinjun Hou, Kenneth R. Zasadny, Julie Cianfrogna, Deborah L. Smith, Ann S. Wright, John T. Lazzaro, Steven Victor O'neil, Patrick Trapa, Emily Miller, Somraj Ghosh, Gabriela Barreiro, John M. Marcek, Margaret M. Zaleska, Jason Barricklow, Michelle Marie Claffey, Lois K. Chenard, Jessica Mancuso, Christopher L. Shaffer, Jessica Whritenour, Gayatri Balan, Brian P. Boscoe, Vinod D. Parikh, Karen J. Coffman, Laigao Chen, Isao Sakurada, Jamison B. Tuttle, Matthew R. Reese, Karki Kapil Kumar
Publikováno v:
Journal of Medicinal Chemistry. 60:7764-7780
We previously observed a cutaneous type IV immune response in nonhuman primates (NHP) with the mGlu5 negative allosteric modulator (NAM) 7. To determine if this adverse event was chemotype- or mechanism-based, we evaluated a distinct series of mGlu5
Autor:
Deborah L. Smith-Shank
Publikováno v:
Chinese Semiotic Studies. 13:245-253
Children and adults absorb and interpret folk tales, fairy tales, and other stories through books, movies, and the vast resources available today on the Internet, including a multitude of storied games. The very best stories are personal, transparent
Autor:
Karen Keifer-Boyd, Deborah L. Smith
Publikováno v:
Visual Arts Research. 43:17-35
Supplementary material for this article can be found online at http://www.press.uillinois.edu/journals/var/media/43.1/keifer-boyd/index.html . Visual Culture & Gender (http://vcg.emitto.net) was conceived and published in 2005 as the first multimedia
Autor:
Christopher Ryan Butler, Timothy J. McCarthy, Ryosuke Arakawa, Deborah L. Smith, Klaas Schildknegt, Justin R. Piro, Lei Zhang, Kevin P. Maresca, Laura A. McAllister, Deane M. Nason, Zhisheng Jia, Sangram Nag, Akihiro Takano, Tarek A. Samad, Christer Halldin, Anabella Villalobos, Steven Victor O'neil, Patrick Trapa
Publikováno v:
Journal of medicinal chemistry. 62(18)
Monoacylglycerol lipase (MAGL), a serine hydrolase extensively expressed throughout the brain, serves as a key gatekeeper regulating the tone of endocannabinoid signaling. Preclinically, inhibition of MAGL is known to provide therapeutic benefits for
Autor:
Deborah L. Smith, Sarah J. Neal, Lei Zhang, Jeremy R. Edgerton, Jennifer E. Davoren, Sarah Grimwood, John T. Lazzaro, Chewah Lee
Publikováno v:
Molecular Pharmacology. 90:177-187
Selective activation of the M1 muscarinic acetylcholine receptor (mAChR) via a positive allosteric modulator (PAM) is a new approach for the treatment of the cognitive impairments associated with schizophrenia and Alzheimer's disease. Herein, we desc
Publikováno v:
Neuropharmacology. 86:174-180
Ketamine is used preclinically and clinically to study schizophrenia and depression. Accordingly, it is imperative to understand the temporal relationship between the central concentrations and N-methyl-d-aspartate receptor (NMDAR) interactions of bo
Autor:
Deborah L. Behringer, Vanessa R. Katona, Deborah L. Smith, Laura A. Hernon-Kenny, Alan T. Lewis, Michael D. Crenshaw
Publikováno v:
Forensic Science International. 241:7-14
A terrorist attack using toxic chemicals is an international concern. The utility of rubber cement and latex body paint as spray-on/spread-on peel-off collection media for signatures attributable to pesticides and chemical warfare agents from interio
Autor:
Patrick Robert Verhoest, Susan E. Drozda, Kenneth R. Zasadny, Emily Miller, Lei Zhang, Kari R. Fonseca, Gabriela Barreiro, Patrick Trapa, Michelle Marie Claffey, Julie Cianfrogna, Marc B. Skaddan, Deborah L. Smith, Margaret M. Zaleska, Joshua R. Dunetz, Christopher L. Shaffer, Jessica Mancuso, Isao Sakurada, Gayatri Balan, Jamison B. Tuttle, Lois K. Chenard, Bruce N. Rogers, Matthew R. Reese, Antonia F. Stepan, Paul Galatsis, Brian P. Boscoe, Daniel P. Walker, Sarah Grimwood, Ann S. Wright, John T. Lazzaro, Karen J. Coffman, Laigao Chen
Publikováno v:
Journal of Medicinal Chemistry. 57:861-877
A novel series of pyrazolopyrazines is herein disclosed as mGluR5 negative allosteric modulators (NAMs). Starting from a high-throughput screen (HTS) hit (1), a systematic structure-activity relationship (SAR) study was conducted with a specific focu