Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Deborah L. Letourneau"'
Publikováno v:
Antimicrobial Agents and Chemotherapy. 46:2344-2348
Hexapeptide (des- N -methylleucyl) derivatives of LY264826 were prepared in order to examine further the role of N-substituted hydrophobic side chains in defining the mechanisms of action of semisynthetic glycopeptide antibiotics. The hexapeptide of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94a47549f610be4a26df71928bf8653
https://doi.org/10.1128/aac.46.8.2344-2348.2002
https://doi.org/10.1128/aac.46.8.2344-2348.2002
Autor:
Deborah L. Letourneau, Norris E. Allen
Publikováno v:
Analytical Biochemistry. 246:62-66
Capillary electrophoretic methods were used to examine dimerization and estimate dimerization constants ( K dim ) for the glycopeptide antibiotics vancomycin, ristocetin A, and LY264826 (A82846B). The K dim for LY264826 was 60- and 200-fold higher th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e760239e801ffedde8f16670cf52e4ff
https://doi.org/10.1006/abio.1997.2004
https://doi.org/10.1006/abio.1997.2004
Publikováno v:
The Journal of Antibiotics. 50:677-684
Vancomycin, LY264826 and four N-substituted derivatives of LY264826 were examined for dimerization, binding to D-alanyl-D-alanine- and D-alanyl-D-lactate-containing cell wall ligands, and binding to bacterial membrane vesicles. The six glycopeptide a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9a41c49706ee9921ac0655492d5fa8
https://doi.org/10.7164/antibiotics.50.677
https://doi.org/10.7164/antibiotics.50.677
Autor:
Ana Sanchez, Thomas R. Parr, Carole J. Boylan, Beatriz López de Uralde, Lourdes Prieto, Justina Martin, Alfonso De Dios, Jesus Ezquerra, Deborah L. Letourneau, Mark Joseph Tebbe, Almudena Rubio, Michele C. Smith, James McGee, Jose Alfredo Martin
Publikováno v:
Journal of medicinal chemistry. 45(20)
The first potent inhibitors of glutamate racemase (MurI) enzyme that show whole cell antibacterial activity are described. Optically pure 4-substituted D-glutamic acid analogues with (2R,4S) stereochemistry and bearing aryl-, heteroaryl-, cinnamyl-,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792df3b6de9750aa23216dbb90950d3e
https://pubmed.ncbi.nlm.nih.gov/12238935
https://pubmed.ncbi.nlm.nih.gov/12238935
Autor:
J. W. Foley, Philip W. Iversen, Carole J. Boylan, H. L. Rocchetta, D. E. Jenkins, Carl L. McMillian, Deborah L. Letourneau, Pamela R. Contag, Thomas R. Parr
A noninvasive, real-time detection technology was validated for qualitative and quantitative antimicrobial treatment applications. The lux gene cluster of Photorhabdus luminescens was introduced into an Escherichia coli clinical isolate, EC14, on a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a705ce5c3f1ab65adf0d1d0a353d1d
https://europepmc.org/articles/PMC90250/
https://europepmc.org/articles/PMC90250/
Publikováno v:
Antimicrobial agents and chemotherapy. 41(1)
LY191145 is an N-alkylated glycopeptide antibiotic (the p-chlorobenzyl derivative of LY264826) with activity against vancomycin-susceptible and -resistant bacteria. Similar to vancomycin, LY191145 inhibited polymerization of peptidoglycan when muramy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91bf8ee9357ee51e325cdec465a520a7
https://pubmed.ncbi.nlm.nih.gov/8980756
https://pubmed.ncbi.nlm.nih.gov/8980756