Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Deborah L. Donahue"'
Autor:
Jonathan J. Molina, Kurt N. Kohler, Christopher Gager, Marissa J. Andersen, Ellsa Wongso, Elizabeth R. Lucas, Andrew Paik, Wei Xu, Deborah L. Donahue, Karla Bergeron, Aleksandra Klim, Michael G. Caparon, Scott J. Hultgren, Alana Desai, Victoria A. Ploplis, Matthew J. Flick, Francis J. Castellino, Ana L. Flores-Mireles
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Catheter-associated urinary tract infections (CAUTIs) are amongst the most common nosocomial infections worldwide and are difficult to treat partly due to development of multidrug-resistance from CAUTI-related pathogens. Importantly, CAUTI o
Externí odkaz:
https://doaj.org/article/3cbe7c971bf8491cb4d5b2b0b02ebda0
Autor:
Daniel E. Hammers, Deborah L. Donahue, Zachary D. Tucker, Brandon L. Ashfeld, Victoria A. Ploplis, Francis J. Castellino, Shaun W. Lee
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Group A Streptococcus (GAS, Streptococcus pyogenes) is a Gram-positive human pathogen that employs several secreted and surface-bound virulence factors to manipulate its environment, allowing it to cause a variety of disease outcomes. One such virule
Externí odkaz:
https://doaj.org/article/397b7e5730124dff91f61b76073941ea
Autor:
Henry M. Vu, Daniel E. Hammers, Zhong Liang, Gabrielle L. Nguyen, Mary E. Benz, Thomas E. Moran, Dustin L. Higashi, Claudia J. Park, Yetunde A. Ayinuola, Deborah L. Donahue, Ana L. Flores-Mireles, Victoria A. Ploplis, Francis J. Castellino, Shaun W. Lee
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Invasive outcomes of Group A Streptococcus (GAS) infections that involve damage to skin and other tissues are initiated when these bacteria colonize and disseminate via an open wound to gain access to blood and deeper tissues. Two critical GAS virule
Externí odkaz:
https://doaj.org/article/cedcfe7385ce465e9a17ac5cc038221c
Autor:
Kamlesh K. Gupta, Deborah L. Donahue, Mayra J. Sandoval-Cooper, Francis J. Castellino, Victoria A. Ploplis
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Plasminogen activator inhibitor-1 (PAI-1) is known to protect mice against cardiac fibrosis. It has been speculated that PAI-1 may regulate cardiac fibrosis by inactivating urokinase-type plasminogen activator (uPA) and ultimately plasmin (P
Externí odkaz:
https://doaj.org/article/b61808fa7a1343d587e54e6e25fbad0a
Autor:
Rebecca A. Flaherty, Deborah L. Donahue, Katelyn E. Carothers, Jessica N. Ross, Victoria A. Ploplis, Francis J. Castellino, Shaun W. Lee
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
The bacterial pathogen Group A Streptococcus (GAS) has been shown to induce a variety of human diseases ranging in severity from pharyngitis to toxic shock syndrome and necrotizing fasciitis. GAS produces a powerful peptide toxin known as Streptolysi
Externí odkaz:
https://doaj.org/article/b305cae75284480f822e0383340eb322
Autor:
Yetunde A. Ayinuola, Deborah L. Donahue, Jermilia Charles, Zhong Liang, Francis J. Castellino, Victoria A. Ploplis
Publikováno v:
Journal of Thrombosis and Haemostasis. 21:1630-1635
Autor:
Deborah L. Donahue, William T. Andrews, Rashna D. Balsara, Adam R. Holmes, Amanda B. Hummon, Francis J. Castellino
Publikováno v:
Analytical and Bioanalytical Chemistry. 412:6275-6285
The N-methyl-D-aspartate (NMDA) receptor is a crucial mediator of pathological glutamate-driven excitotoxicity and subsequent neuronal death in acute ischemic stroke. Although the roles of the NMDAR's composite GluN2A-C subunits have been investigate
Autor:
Kamlesh K Gupta, Deborah L Donahue, Mayra J Sandoval-Cooper, Francis J Castellino, Victoria A Ploplis
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120728 (2015)
Sepsis-induced acute kidney injury (AKI) contributes to the high mortality and morbidity in patients. Although the pathogenesis of AKI during sepsis is poorly understood, it is well accepted that plasminogen activator inhibitor-1 (PAI-1) and vitronec
Externí odkaz:
https://doaj.org/article/2ebb137a2bcc41899be7cf91e2bfd9aa
Autor:
Jeffrey A Mayfield, Zhong Liang, Garima Agrahari, Shaun W Lee, Deborah L Donahue, Victoria A Ploplis, Francis J Castellino
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100698 (2014)
The cluster of virulence sensor (CovS)/responder (CovR) two-component operon (CovRS) regulates ∼15% of the genes of the Group A Streptococcal pyogenes (GAS) genome. Bacterial clones containing inactivating mutations in the covS gene have been isola
Externí odkaz:
https://doaj.org/article/34ad268c760145c9bb8b3c83fd5e2b3d
Autor:
Victoria A. Ploplis, Francis J. Castellino, Mijoon Lee, Bill Boggess, Katelyn E. Carothers, Jeffrey A. Mayfield, Deborah L. Donahue, Shaun W. Lee, Zhong Liang
Publikováno v:
Journal of Bacteriology
Streptococcus pyogenes (GAS) causes a range of diseases in humans, ranging from mild to severe, and produces many virulence factors in order to be a successful pathogen. One factor produced by many GAS strains is the protease SpeB, which has been stu