Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Deborah L Galson"'
Publikováno v:
Journal of Bone Oncology, Vol 13, Iss , Pp 62-70 (2018)
Multiple myeloma (MM) is the most frequent cancer to involve the skeleton with patients developing osteolytic bone lesions due to hyperactivation of osteoclasts and suppression of BMSCs differentiation into functional osteoblasts. Although new therap
Externí odkaz:
https://doaj.org/article/370f384d84a040bf9a8e82f8bf0c3ed9
Autor:
Daniela N Petrusca, Denise Toscani, Feng-Ming Wang, Cheolkyu Park, Colin D Crean, Judith L Anderson, Silvia Marino, Khalid S Mohammad, Dan Zhou, Rebecca Silbermann, Quanhong Sun, Noriyoshi Kurihara, Deborah L Galson, Nicola Giuliani, G David Roodman
Publikováno v:
Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-14 (2018)
Abstract Background In spite of major advances in treatment, multiple myeloma (MM) is currently an incurable malignancy due to the emergence of drug-resistant clones. We previously showed that MM cells upregulate the transcriptional repressor, growth
Externí odkaz:
https://doaj.org/article/208324c0cf064ed1a922de5482666482
Publikováno v:
JBMR Plus, Vol 3, Iss 3, Pp n/a-n/a (2019)
ABSTRACT Multiple myeloma (MM) bone disease is characterized by the development of osteolytic lesions, which cause severe complications affecting the morbidity, mortality, and treatment of myeloma patients. Myeloma tumors seeded within the bone micro
Externí odkaz:
https://doaj.org/article/0f1fe92918b84f49b8666bfb0a39b2f6
Autor:
Juraj Adamik, Kent Z Q Wang, Sebnem Unlu, An-Jey A Su, Gillian M Tannahill, Deborah L Galson, Luke A O'Neill, Philip E Auron
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70622 (2013)
Interleukin-1β and Tumor Necrosis Factor α play related, but distinct, roles in immunity and disease. Our study revealed major mechanistic distinctions in the Toll-like receptor (TLR) signaling-dependent induction for the rapidly expressed genes (I
Externí odkaz:
https://doaj.org/article/d6aa7508b0234904a188fdc251d14e52
Autor:
Shivendra V. Singh, Prashant N. Kumta, Boeun Lee, Rebecca J. Watters, Kurt R. Weiss, Deborah L. Galson, Juraj Adamik, Carolyn J. Anderson, Joseph D. Latoche, Lea Nyiranshuti, Krishna B. Singh, Su-Hyeong Kim, Eun-Ryeong Hahm, Subrata K. Pore
Consensus binding sequences for transcription factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd090210304acc1e6136632d1f1ace2
https://doi.org/10.1158/1535-7163.22521588.v1
https://doi.org/10.1158/1535-7163.22521588.v1
Autor:
Shivendra V. Singh, Prashant N. Kumta, Boeun Lee, Rebecca J. Watters, Kurt R. Weiss, Deborah L. Galson, Juraj Adamik, Carolyn J. Anderson, Joseph D. Latoche, Lea Nyiranshuti, Krishna B. Singh, Su-Hyeong Kim, Eun-Ryeong Hahm, Subrata K. Pore
Expression of runt-related transcription factor 2 (RUNX2) protein in luminal-type breast cancers and normal mammary tissues.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d53e8a3486cb065405199697dea1239
https://doi.org/10.1158/1535-7163.22521597
https://doi.org/10.1158/1535-7163.22521597
Autor:
Shivendra V. Singh, Prashant N. Kumta, Boeun Lee, Rebecca J. Watters, Kurt R. Weiss, Deborah L. Galson, Juraj Adamik, Carolyn J. Anderson, Joseph D. Latoche, Lea Nyiranshuti, Krishna B. Singh, Su-Hyeong Kim, Eun-Ryeong Hahm, Subrata K. Pore
Bone is the most preferred site for colonization of metastatic breast cancer cells for each subtype of the disease. The standard of therapeutic care for breast cancer patients with bone metastasis includes bisphosphonates (e.g., zoledronic acid), whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd2a024fd1a914000a0387ee50e9c13
https://doi.org/10.1158/1535-7163.c.6543075.v1
https://doi.org/10.1158/1535-7163.c.6543075.v1
Autor:
David N. Boone, Yuanyuan Chen, Kenneth J. DeHaan, Sheila Pratt, Tobias A. Baker, Steve Evans, Malihe Alikhani, Steffi Oesterreich, Jennifer M. Atkinson, Andrew W. Duncan, Deborah L. Galson, Greg M. Delgoffe, Tullia C. Bruno, Solomon Livshits, Richard D. Boyce, Joseph C. Ayoob
Publikováno v:
J STEM Outreach
The University of Pittsburgh Medical Center Hillman Cancer Center Academy (Hillman Academy) has the primary goal of reaching high school students from underrepresented and disadvantaged backgrounds and guiding them through a cutting-edge research and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0b1ee826dad0b18fda472b94a26cbd
https://europepmc.org/articles/PMC9997544/
https://europepmc.org/articles/PMC9997544/
Autor:
Daniela N, Petrusca, Patrick L, Mulcrone, David A, Macar, Ryan T, Bishop, Evgeny, Berdyshev, Attaya, Suvannasankha, Judith L, Anderson, Quanhong, Sun, Philip E, Auron, Deborah L, Galson, G David, Roodman
Publikováno v:
Cancers. 14(3)
Multiple myeloma (MM) remains incurable for most patients due to the emergence of drug resistant clones. Here we report a p53-independent mechanism responsible for Growth Factor Independence-1 (GFI1) support of MM cell survival by its modulation of s
Autor:
Peng Zhang, David A. Macar, Quanhong Sun, Deborah L. Galson, Sree H Pulugulla, Juraj Adamik, Philip E. Auron, Konstantinos Lontos
Publikováno v:
J Bone Miner Res
Key osteoclast (OCL) regulatory gene promoters in bone marrow-derived monocytes harbor bivalent histone modifications that combine activating Histone 3 lysine 4 tri-methyl (H3K4me3) and repressive H3K27me3 marks, which upon RANKL stimulation resolve