Výsledky vyhledávání - "Deborah L Diamond"

Akademický článek

Genomic analysis reveals a potential role for cell cycle perturbation in HCV-mediated apoptosis of cultured hepatocytes.

Autor: Kathie-Anne Walters, Andrew J Syder, Sharon L Lederer, Deborah L Diamond, Bryan Paeper, Charles M Rice, Michael G Katze

Publikováno v: PLoS Pathogens, Vol 5, Iss 1, p e1000269 (2009)

The mechanisms of liver injury associated with chronic HCV infection, as well as the individual roles of both viral and host factors, are not clearly defined. However, it is becoming increasingly clear that direct cytopathic effects, in addition to i

Externí odkaz: https://doaj.org/article/043b8f260cfd40e3be4ba75102e49306

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Advancing the High Throughput Identification of Liver Fibrosis Protein Signatures Using Multiplexed Ion Mobility Spectrometry

Publikováno v: Molecular & Cellular Proteomics. 13:1119-1127

Rapid diagnosis of disease states using less invasive, safer, and more clinically acceptable approaches than presently employed is a crucial direction for the field of medicine. While MS-based proteomics approaches have attempted to meet these object

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c741518419983f659b9abd6abc20a2
https://doi.org/10.1074/mcp.m113.034595

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Chronic immune activation is a distinguishing feature of liver and PBMC gene signatures from HCV/HIV coinfected patients and may contribute to hepatic fibrogenesis

Autor: Victoria S. Carter, Lisa V. Thomassen, Roger Ulrich, Margaret C. Shuhart, Deborah L. Diamond, Christopher J. Roberts, Janine T. Bryan, I-Ming Wang, Christopher M. Williams, Yudong He, Sean Proll, Marcus J. Korth, Razvan Cristescu, Angela L. Rasmussen, Michael G. Katze

Publikováno v: Virology. 430(1):43-52

Hepatitis C virus/human immunodeficiency virus (HCV/HIV) coinfected patients demonstrate accelerated progression to severe liver injury in comparison to HCV monoinfected patients, although the underlying mechanisms are unclear owing to infection of s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264f9e822a5de7d2bf4dfc077105c434

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Systems Virology Identifies a Mitochondrial Fatty Acid Oxidation Enzyme, Dodecenoyl Coenzyme A Delta Isomerase, Required for Hepatitis C Virus Replication and Likely Pathogenesis

Autor: Deborah L. Diamond, Melissa M. Matzke, Katrina M. Waters, Sarah E. Belisle, Richard D. Smith, Thomas O. Metz, Michael G. Katze, Angela L. Rasmussen, Marcus J. Korth, Xiaoli Gao, Jason E. McDermott, Victoria S. Carter

Publikováno v: Journal of Virology. 85:11646-11654

We previously employed systems biology approaches to identify the mitochondrial fatty acid oxidation enzyme dodecenoyl coenzyme A delta isomerase (DCI) as a bottleneck protein controlling host metabolic reprogramming during hepatitis C virus (HCV) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad5a524271ade562031fa7309d76db8
https://doi.org/10.1128/jvi.05605-11

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Is systems biology the key to preventing the next pandemic?

Autor: Sarah E. Belisle, Jennifer R. Tisoncik, Michael G. Katze, Marcus J. Korth, Deborah L. Diamond

Publikováno v: Future Virology

Sporadic outbreaks of epizootics including SARS coronavirus and H5N1 avian influenza remind us of the potential for communicable diseases to quickly spread into worldwide epidemics. To confront emerging viral threats, nations have implemented strateg

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Virus–host interactions: from systems biology to translational research

Autor: Yu Li, Eric Y. Chan, Marcus J. Korth, Michael G. Katze, Deborah L. Diamond, Xinxia Peng

Publikováno v: Current Opinion in Microbiology. 12:432-438

Research embracing systems biology approaches and careful analysis of the critical host response has greatly expanded our understanding of infectious diseases. First-generation studies based on genomics and proteomics have made significant progress i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531340b7eec88908a4e0e6ff815b4ed0
https://doi.org/10.1016/j.mib.2009.06.003

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Integrated Molecular Signature of Disease: Analysis of Influenza Virus-Infected Macaques through Functional Genomics and Proteomics

Autor: Jon M. Jacobs, N. Van Hoeven, Adolfo García-Sastre, Carole R. Baskin, Marina A. Gritsenko, Michael G. Katze, David G. Camp, Tracey Baas, Terrence M. Tumpey, Matthew J. Thomas, Victoria S. Carter, Sean Proll, Helle Bielefeldt-Ohmann, Deborah L. Diamond, Renee R. Hukkanen, Thomas H. Teal, Richard D. Smith, Z. R. Caldwell

Publikováno v: Journal of Virology

Recent outbreaks of avian influenza in humans have stressed the need for an improved nonhuman primate model of influenza pathogenesis. In order to further develop a macaque model, we expanded our previous in vivo genomics experiments with influenza v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1968f5b2ba37c5281035e5029ffa7481
https://doi.org/10.1128/jvi.00851-06

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Virology in the 21st century: finding function with functional genomics

Autor: James C. Wallace, Michael G. Katze, Deborah L. Diamond, Sean Proll, Marcus J. Korth

Publikováno v: Future Virology. 1:47-53

When functional genomics first appeared on the scene, the ability to perform global gene expression and protein profiling was hailed as a revolutionary new way to study biologic systems, likely to result in dramatic new discoveries. As time has passe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5c9cbc9ce28f218a4833f3b888dae0a
https://doi.org/10.2217/17460794.1.1.47

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