Výsledky vyhledávání - "Deborah K. Morrison"

Akademický článek

Protocol for measuring BRAF autoinhibition in live cells using a proximity-based NanoBRET assay

Autor: Russell Spencer-Smith, Deborah K. Morrison

Publikováno v: STAR Protocols, Vol 4, Iss 3, Pp 102461- (2023)

Summary: BRAF is frequently activated via mutation in human cancer and the RASopathy syndromes; however, for BRAF activation to occur, autoinhibitory interactions between the regulatory and catalytic domains must be relieved. Here, we present a proxi

Externí odkaz: https://doaj.org/article/5e29c861fb4349de9a720b0ac62914c5

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Akademický článek

Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation

Autor: Brandon M. Murphy, Elizabeth M. Terrell, Venkat R. Chirasani, Tirzah J. Weiss, Rachel E. Lew, Andrea M. Holderbaum, Aastha Dhakal, Valentina Posada, Marie Fort, Michael S. Bodnar, Leiah M. Carey, Min Chen, Craig J. Burd, Vincenzo Coppola, Deborah K. Morrison, Sharon L. Campbell, Christin E. Burd

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

The factors that determine the distinct profiles of NRAS mutants across different tumor types remain unclear. Here, the authors use an allelic series of conditional mouse models to investigate the molecular mechanisms underlying the enrichment of spe

Externí odkaz: https://doaj.org/article/a16f75dc242345688e57e18ad40b740a

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Akademický článek

Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding

Autor: Juliana A. Martinez Fiesco, David E. Durrant, Deborah K. Morrison, Ping Zhang

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

RAF kinases are essential for RAS protein signalling but how RAS binding regulates dimerization and activation of RAF has remained unclear. Here, the authors report cryoEM structures that provide mechanistic insights into the RAS-mediated monomer-to-

Externí odkaz: https://doaj.org/article/34e7836b1f4c4780b3bb919337e7db0b

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Akademický článek

Synthesis and Biological Evaluation of New Madecassic Acid Derivatives Targeting ERK Cascade Signaling

Autor: Ana S. C. Valdeira, Daniel A. Ritt, Deborah K. Morrison, James B. McMahon, Kirk R. Gustafson, Jorge A. R. Salvador

Publikováno v: Frontiers in Chemistry, Vol 6 (2018)

In the present study, a series of novel madecassic acid derivatives was synthesized and screened against the National Cancer Institute's 60 human cancer cell line panel. Among them, compounds 5, 12, and 17 displayed potent and highly differential ant

Externí odkaz: https://doaj.org/article/2d0c9aca483442fcab6a4d8d688fff18

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