Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Deborah J. Rew"'
1
Isolation, structure determination and squalene synthase activity of L-731,120 and L-731,128, alkyl citrate analogs of zaragozic acids A and B
Autor: Leslie A. Koch, Claude Dufresne, Kent E. Göklen, Deborah L. Zink, James D. Bergstrom, Kenneth E. Wilson, Henry Joshua, Guy H. Harris, Deborah J. Rew, P. Salmon, Marc M. Kurtz
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:2403-2408
Two new alkyl citrates, L-731,120 and L-731,128, with alkyl chains corresponding to those of zaragozic acids A and B, were isolated as minor components of large scale fungal fermentations producing zaragozic acid A and B. They are submicromolar inhib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a03734c6c7fa4bde86fed35295fcc7c2
https://doi.org/10.1016/0960-894x(95)00419-t
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2
Design and synthesis of squalene synthase inhibitors - acylic mimics of the zaragazic acids
Autor: Robichaud Albert Jean, James D. Bergstrom, Deborah J. Rew, Gregory D. Berger, C. H. Kuo
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:1591-1594
A simple and versatile synthetic scheme employing d -malic acid as the principal building block permits the ready preparation of acyclic mimics of the squalene synthase inhibitor zaragozic acid A (ZA-A). Several compounds which were synthesized accor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e670c3cd67572996662cde44bea75ee
https://doi.org/10.1016/s0960-894x(01)80572-2
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3
Diesters of zaragozic acid A: Synthesis and biological activity
Autor: Gregory D. Berger, Deborah J. Rew, Tesfaye Biftu, George A. Doss, Robert W. Marquis, Yuan-Ching P. Chiang, James D. Bergstrom, Sandra P. Plevyak, Marc M. Kurtz
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:2029-2034
Diesters of zaragozic acid A were synthesized and tested in rat liver squalene synthase and oral mouse cholesterol biosynthesis assays. Of these, 3-isopentyl-4-pivaloyloxymethyl and 3-isopentyl-4-acetoxymethyl esters gave ED50's of 9 mg/kg and 6 mg/k
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f43d73a65132dd80a518f407ddfcebf
https://doi.org/10.1016/s0960-894x(01)81008-8
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5
The isolation and structure elucidation of zaragozic acid C, a novel potent squalene synthase inhibitor
Autor: Rosalind G. Jenkins, Claude Dufresne, Maria S. Meinz, Nallin Mary, Gerald F. Bills, Fernando Pelaez, Charlotte Trainor, Janet C. Onishi, James D. Bergstrom, Leeyuan Huang, Kenneth E. Wilson, Deborah L. Zink, Marc M. Kurtz, James A. Milligan, John A. Smith, Deborah J. Rew, Ken Bartizal, Marina Mojena
Publikováno v: Tetrahedron. 48:10221-10226
The novel zaragozic acid C ( 1 ) has been isolated as a potent inhibitor of squalene synthase. It was found to be a competitive inhibitor of rat liver squalene synthase with an apparent K i of 45 ± 15 pM, and a broad spectrum antifungal agent agains
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e44513a3f50e9b787605b8f46a4a29c
https://doi.org/10.1016/s0040-4020(01)88327-7
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6
Antimicrobial activity of viridiofungins
Autor: Angela Basilio, Francisca Vicente, James E. Curotto, Myra B. Kurtz, Mary Nallin-Omstead, Deborah J. Rew, John R. Thompson, L. Huang, James D. Bergstrom, Fernando Pelaez, M. J. Salvatore, Maria S. Meinz, Janet C. Onishi, James A. Milligan
Publikováno v: The Journal of antibiotics. 50(4)
A family of aminoacyl alkyl citrate compounds called viridiofungins, are novel squalene synthase inhibitors. The compounds have broad spectrum fungicidal activity but lack antibacterial activity. Although the compounds inhibit squalene synthase, the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0faaf442ac13d9d53899d858c937162e
https://pubmed.ncbi.nlm.nih.gov/9186560
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7
Zaragozic acids D and D2: potent inhibitors of squalene synthase and of Ras farnesyl-protein transferase
Autor: Jon D. Polishook, Keith C. Silverman, Maria S. Meinz, Sheo B. Singh, Deborah J. Rew, Deborah L. Zink, Russell B. Lingham, Fernando Pelaez, Marina Mojena, Jackson B. Gibbs, James D. Bergstrom, Claude Dufresne, Carmen Cascales, Kenneth E. Wilson, Leeyuan Huang
Publikováno v: Journal of natural products. 56(11)
Two new zaragozic acids, D and D 2 , have been isolated from the keratinophilic fungus Amauroascus niger. Zaragozic acids D [4] and D 2 [5] are related to the previously describe zaragozic acids A [1], B [2], and C [3] and are potent inhibitors of sq
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6b519e5529c0f566d36b7af58ae42b
https://pubmed.ncbi.nlm.nih.gov/8289063
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8
Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase
Autor: Vanmiddlesworth Frank L, Deborah J. Rew, James D. Bergstrom, Otto D. Hensens, J D Karkas, V S Bansal, Richard G. Bostedor, Marc M. Kurtz, Claude Dufresne, A M Amend
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 90(1)
Three closely related fungal metabolites, zaragozic acids A, B, and C, that are potent inhibitors of squalene synthase have been isolated and characterized. Zaragozic acids A, B, and C were produced from an unidentified sterile fungal culture, Sporor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd62ae43f484c7c769800eecf35102ac
https://pubmed.ncbi.nlm.nih.gov/8419946
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