Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Deborah J. Keszenman"'
1
Akademický článek
Evaluation of Histone Deacetylase Inhibitors as Radiosensitizers for Proton and Light Ion Radiotherapy
Autor: Alicia M. Johnson, Paula V. Bennett, Katherine Z. Sanidad, Anthony Hoang, James H. Jardine, Deborah J. Keszenman, Paul F. Wilson
Publikováno v: Frontiers in Oncology, Vol 11 (2021)
Significant opportunities remain for pharmacologically enhancing the clinical effectiveness of proton and carbon ion-based radiotherapies to achieve both tumor cell radiosensitization and normal tissue radioprotection. We investigated whether pretrea
Externí odkaz: https://doaj.org/article/223c984ca18d4294acd276e3bc607b57
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2
Akademický článek
PARP Inhibitor Olaparib Causes No Potentiation of the Bleomycin Effect in VERO Cells, Even in the Presence of Pooled ATM, DNA-PK, and LigIV Inhibitors
Autor: Valentina Perini, Michelle Schacke, Pablo Liddle, Salomé Vilchez-Larrea, Deborah J. Keszenman, Laura Lafon-Hughes
Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 21, p 8288 (2020)
Poly(ADP-ribosyl)polymerase (PARP) synthesizes poly(ADP-ribose) (PAR), which is anchored to proteins. PAR facilitates multiprotein complexes’ assembly. Nuclear PAR affects chromatin’s structure and functions, including transcriptional regulation.
Externí odkaz: https://doaj.org/article/6f618da618d84e7287dc111dd1969cc3
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3
Fast and biphasic 8-nitroguanine production from guanine and peroxynitrite
Autor: Ana G. Sánchez, M. Natalia Ibargoyen, Mauricio Mastrogiovanni, Rafael Radi, Deborah J. Keszenman, R. Daniel Peluffo
Publikováno v: Free radical biologymedicine. 193(Pt 1)
Guanine (Gua), among purines, is a preferred oxidation/nitration target because of its low one-electron redox potential. The reactive oxygen/nitrogen species peroxynitrite (ONOO
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1739b0ff375f171929c9da4f42f6fa71
https://pubmed.ncbi.nlm.nih.gov/36410073
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5
Evaluation of Histone Deacetylase Inhibitors as Radiosensitizers for Proton and Light Ion Radiotherapy
Autor: Deborah J. Keszenman, Alicia M. Johnson, Katherine Z. Sanidad, James Jardine, Anthony Hoang, Paul F. Wilson, Paula V. Bennett
Publikováno v: Frontiers in Oncology
Frontiers in Oncology, Vol 11 (2021)
Significant opportunities remain for pharmacologically enhancing the clinical effectiveness of proton and carbon ion-based radiotherapies to achieve both tumor cell radiosensitization and normal tissue radioprotection. We investigated whether pretrea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa09d6c603faadd64553578bab27541
http://europepmc.org/articles/PMC8426582
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6
Dose-Rate Effects of Protons and Light Ions for DNA Damage Induction, Survival and Transformation in Apparently Normal Primary Human Fibroblasts
Autor: Paula V. Bennett, Alicia M. Johnson, Sarah E. Ackerman, Pankaj Chaudhary, Deborah J. Keszenman, Paul F. Wilson
Publikováno v: Radiation research. 197(3)
We report on effects of low-dose exposures of accelerated protons delivered at high-dose rate (HDR) or a simulated solar-particle event (SPE) like low-dose rate (LDR) on immediate DNA damage induction and processing, survival and in vitro transformat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c823b98ba2bd944193bb2bdb2753c5e
https://pubmed.ncbi.nlm.nih.gov/34910217
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7
SARS-CoV-2 Biology Insights, Part III. The COVID-19 latency hypotheses and the fertility question. (Preprint)
Autor: Laura Lafon-Hughes, Deborah J Keszenman
BACKGROUND As already reviewed in Part I, SARS-CoV-2 Spike is optimized for infection of multiple cell types, including immune cells. Accordingly, as reviewed in Part II, it can generate a systemic persistent infection. OBJECTIVE Now, two questions a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f262a153ba1954b8a832e3e77abfc99
https://doi.org/10.2196/preprints.21596
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8
SARS-CoV-2 Biology Insights, Part II. COVID-19 as a systemic persistent infection: narrative review. (Preprint)
Autor: Laura Lafon-Hughes, Deborah J Keszenman
BACKGROUND As reviewed in Part I, SARS-CoV-2 Spike presents special features including a furin cleavage site and 4 HIV-like sequences that are expected to facilitate viral infection spreading. OBJECTIVE To evaluate whether there is evidence regarding
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61e85fe32c4f36dffd882d92f78e089a
https://doi.org/10.2196/preprints.21595
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10
PARP Inhibitor Olaparib Causes No Potentiation of the Bleomycin Effect in VERO Cells, Even in the Presence of Pooled ATM, DNA-PK, and LigIV Inhibitors
Autor: Deborah J. Keszenman, Valentina Perini, Michelle Schacke, Salomé Vilchez-Larrea, Laura Lafon-Hughes, Pablo Liddle
Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 8288, p 8288 (2020)
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International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 21; Issue 21; Pages: 8288
Poly(ADP-ribosyl)polymerase (PARP) synthesizes poly(ADP-ribose) (PAR), which is anchored to proteins. PAR facilitates multiprotein complexes’ assembly. Nuclear PAR affects chromatin’s structure and functions, including transcriptional regulation.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b1914612802900fc8795539e824530
https://doi.org/10.3390/ijms21218288
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