Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Deborah J Nelson"'
Autor:
Christopher R Weber, Guo Hua Liang, Yitang Wang, Sudipto Das, Le Shen, Alan S L Yu, Deborah J Nelson, Jerrold R Turner
Publikováno v:
eLife, Vol 4 (2015)
Intercellular tight junctions form selectively permeable barriers that seal the paracellular space. Trans-tight junction flux has been measured across large epithelial surfaces, but conductance across individual channels has never been measured. We r
Externí odkaz:
https://doaj.org/article/58c57ffb51af41dbb6e0a5e1338b1f93
Autor:
Hongshu Sui, Yaling Yi, Jianrong Yao, Bo Liang, Xingshen Sun, Shanming Hu, Aliye Uc, Deborah J Nelson, Katie Larson Ode, Louis H Philipson, John F Engelhardt, Andrew W Norris
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90519 (2014)
Ferrets are an important emerging model of cystic fibrosis related diabetes. However, there is little documented experience in the use of advanced techniques to quantify aspects of diabetes pathophysiology in the ferret. Glycemic clamps are the gold
Externí odkaz:
https://doaj.org/article/bb25f996055e47678ff1fd0d26ef77c4
Autor:
Irina L. Tourkova, Quitterie C. Larrouture, Silvia Liu, Jianhua Luo, Katherine E. Shipman, Kelechi M. Onwuka, Ora A. Weisz, Vladimir Riazanski, Deborah J. Nelson, Matthew L. MacDonald, Paul H. Schlesinger, Harry C. Blair
Publikováno v:
Bone Reports, Vol 21, Iss , Pp 101763- (2024)
Acid transport is required for bone synthesis by osteoblasts. The osteoblast basolateral surface extrudes acid by Na+/H+ exchange, but apical proton uptake is undefined. We found high expression of the Cl−/H+ exchanger ClC3 at the bone apical surfa
Externí odkaz:
https://doaj.org/article/bf7bf14d1982441993e7c2bea477f974
Autor:
Vladimir Riazanski, Gerardo Mauleon, Kilean Lucas, Samuel Walker, Adriana M. Zimnicka, James L. McGrath, Deborah J. Nelson
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Riazanski et al describe a platform to capture extracellular vesicles (EVs) using a nanoporous silicon nitride membrane, investigate the expression of NHE1 protein on the surface of EVs and monitor the transport of Na+ and H+ at the single EV level.
Externí odkaz:
https://doaj.org/article/98864c1740fb4e14ba8f46b059eb5d8e
Autor:
Guoping Li, Tianji Chen, James Dahlman, Lola Eniola‐Adefeso, Ionita C. Ghiran, Peter Kurre, Wilbur A. Lam, Jennifer K. Lang, Eduardo Marbán, Pilar Martín, Stefan Momma, Malcolm Moos, Deborah J. Nelson, Robert L. Raffai, Xi Ren, Joost P. G. Sluijter, Shannon L. Stott, Gordana Vunjak‐Novakovic, Nykia D. Walker, Zhenjia Wang, Kenneth W. Witwer, Phillip C. Yang, Martha S. Lundberg, Margaret J. Ochocinska, Renee Wong, Guofei Zhou, Stephen Y. Chan, Saumya Das, Prithu Sundd
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 2, Pp n/a-n/a (2023)
Abstract Extracellular vesicles (EVs) carry diverse bioactive components including nucleic acids, proteins, lipids and metabolites that play versatile roles in intercellular and interorgan communication. The capability to modulate their stability, ti
Externí odkaz:
https://doaj.org/article/18fab64d303f4b96a14f506db0bcec94
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103636- (2022)
Summary: Acidification in intracellular organelles is tightly linked to the influx of Cl− counteracting proton translocation by the electrogenic V-ATPase. We quantified the dynamics of Cl− transfer accompanying cargo incorporation into single pha
Externí odkaz:
https://doaj.org/article/5852ba0c304f43609f8a5f9e6960e248
Autor:
Irina L. Tourkova, Vladimir Riazanski, Kelechi M. Onwuka, Jonathan Franks, Steven F. Dobrowolski, Harry C. Blair, Quitterie C. Larrouture, Donna B. Stolz, Deborah J. Nelson, Paul H. Schlesinger
Publikováno v:
Biochem Biophys Res Commun
Osteoblasts in vivo form an epithelial-like layer with tight junctions between cells. Bone formation involves mineral transport into the matrix and acid transport to balance pH levels. To study the importance of the pH gradient in vitro, we used Tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6501762965767ba5379d3d4a27f7cc5
https://doi.org/10.1016/j.bbrc.2021.09.075
https://doi.org/10.1016/j.bbrc.2021.09.075
Autor:
Harry C. Blair, Paul H. Schlesinger, Irina L. Tourkova, Donna B. Stolz, Evan C. Ray, Vladimir Riazanski, Deborah J. Nelson
Publikováno v:
Am J Physiol Cell Physiol
Bone differs from other connective tissues; it is isolated by a layer of osteoblasts that are connected by tight and gap junctions. This allows bone to create dense lamellar type I collagen, control pH, mineral deposition, and regulate water content
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32ca7225f648559098218f08a2afd17
https://doi.org/10.1152/ajpcell.00120.2019
https://doi.org/10.1152/ajpcell.00120.2019
Autor:
Vladimir Riazanski, Gerardo Mauleon, Kilean Lucas, Samuel Walker, Adriana M. Zimnicka, James L. McGrath, Deborah J. Nelson
Publikováno v:
Communications Biology
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Extracellular vesicles (EVs) are cell-derived membranous structures carrying transmembrane proteins and luminal cargo. Their complex cargo requires pH stability in EVs while traversing diverse body fluids. We used a filtration-based platform to captu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef12546a8ce6e2b9ee156b95a0ed1f56
https://pubmed.ncbi.nlm.nih.gov/35013561
https://pubmed.ncbi.nlm.nih.gov/35013561
Publikováno v:
iScience
iScience, Vol 23, Iss 11, Pp 101759-(2020)
iScience, Vol 23, Iss 11, Pp 101759-(2020)
Summary The relative contribution of the two phagosomal catabolic processes, oxidative and metabolic, was assessed in the killing of Pseudomonas aeruginosa in phagosomes of alveolar macrophages (AMs) from wild-type (p47-phox+/+) or NOX-defective (p47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557b17b235904c27828e93c60f586e18
http://europepmc.org/articles/PMC7677711
http://europepmc.org/articles/PMC7677711