Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Deborah J Gorth"'
Publikováno v:
International Journal of Nanomedicine, Vol 2011, Iss default, Pp 343-350 (2011)
Deborah J Gorth1, David M Rand2, Thomas J Webster11School of Engineering, 2Department of Ecology and Evolutionary Biology, Brown University, Providence, RI, USABackground: Consumer nanotechnology is a growing industry. Silver nanoparticles are the mo
Externí odkaz:
https://doaj.org/article/9f79cc13104148f996489e626063088b
Autor:
Deborah J Gorth, John T Martin, George R Dodge, Dawn M Elliott, Neil R Malhotra, Robert L Mauck, Lachlan J Smith
Publikováno v:
Journal of Experimental Orthopaedics, Vol 1, Iss 1, Pp n/a-n/a (2014)
Abstract Background Inflammatory cytokines such as interleukin‐1 beta (IL‐1β) contribute to the progression of intervertebral disc degeneration. Previously we demonstrated, in vitro, that by delivering interleukin‐1 receptor antagonist (IL‐1
Externí odkaz:
https://doaj.org/article/fe2e549cefbd48b3aeabeb44363abd7b
Publikováno v:
JAMA Network Open
Key Points Question Are objective and subjective evaluations of men and women participating in third-year internal medicine clerkships significantly associated with gender? Findings In this cohort study of 277 students from a single academic center,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a8f26ff1192362cb80b62ae202b209
http://europepmc.org/articles/PMC8254135
http://europepmc.org/articles/PMC8254135
Publikováno v:
J Bone Miner Res
The inflammatory cytokine tumor necrosis factor alpha (TNFα) is considered to play a key role in the pathogenesis of intervertebral disc disease. To evaluate the importance of this cytokine we examined the inflammatory environment and spinal phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7c1b91c4a8f6e5732a6865bc9ce60c
https://europepmc.org/articles/PMC7145745/
https://europepmc.org/articles/PMC7145745/
Autor:
Dawn M. Elliott, Neil R. Malhotra, Weiliam Chen, Joseph A. Chiaro, Lachlan J. Smith, Robert L. Mauck, Brent L. Showalter, Deborah J Gorth, Elizabeth E. Beattie
Publikováno v:
Tissue Engineering Part A. 20:1841-1849
Intervertebral disc degeneration is implicated as a major cause of low-back pain. There is a pressing need for new regenerative therapies for disc degeneration that restore native tissue structure and mechanical function. To that end we investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102da9331dc961924713253e5a9fbbb7
https://doi.org/10.1089/ten.tea.2013.0516
https://doi.org/10.1089/ten.tea.2013.0516
Autor:
John T. Martin, Brian D. Harfe, Lachlan J. Smith, Deborah J Gorth, Elizabeth E. Beattie, Dawn M. Elliott
Publikováno v:
Journal of Orthopaedic Research. 31:1276-1282
Low back pain is a significant socioeconomic burden and intervertebral disc degeneration has been implicated as a cause. A reliable animal model of disc degeneration is necessary to evaluate therapeutics, and functional metrics are essential to quant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46cef3fa8f2227ef2ba172c5f86bca78
https://doi.org/10.1002/jor.22355
https://doi.org/10.1002/jor.22355
Publikováno v:
Discovery medicine. 20(110)
The intervertebral disc is a unique avascular organ that supports axial skeleton flexion and rotation. The high proteoglycan content of the nucleus pulposus tissue, present at the center of the disc, is pivotal for its mechanical function, distributi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ca336ef984e500c368db6aca98c1e0d
https://pubmed.ncbi.nlm.nih.gov/26562470
https://pubmed.ncbi.nlm.nih.gov/26562470
Autor:
Deborah J, Gorth, Katherine E, Lothstein, Joseph A, Chiaro, Megan J, Farrell, George R, Dodge, Dawn M, Elliott, Neil R, Malhotra, Robert L, Mauck, Lachlan J, Smith
Publikováno v:
Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 33(5)
Degeneration of the intervertebral discs is strongly implicated as a cause of low back pain. Since current treatments for discogenic low back pain show poor long-term efficacy, a number of new, biological strategies are being pursued. For such therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d5a71288d742a75be0b031b9a3f1284
https://pubmed.ncbi.nlm.nih.gov/25640328
https://pubmed.ncbi.nlm.nih.gov/25640328
Autor:
Nader M. Hebela, Deborah J Gorth, Robert L. Mauck, Lachlan J. Smith, Neil R. Malhotra, Dawn M. Elliott, John T. Martin, George R. Dodge
Publikováno v:
ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology.
Inflammation plays a central role in the progression of disc degeneration, which is strongly implicated as a cause of low back pain. The objectives of this in vivo study were: first to investigate whether PLGA microspheres could be retained in the di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da08c360063e4945764c25832086af90
https://doi.org/10.1115/nemb2013-93134
https://doi.org/10.1115/nemb2013-93134
Autor:
John T, Martin, Deborah J, Gorth, Elizabeth E, Beattie, Brian D, Harfe, Lachlan J, Smith, Dawn M, Elliott
Publikováno v:
Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 31(8)
Low back pain is a significant socioeconomic burden and intervertebral disc degeneration has been implicated as a cause. A reliable animal model of disc degeneration is necessary to evaluate therapeutics, and functional metrics are essential to quant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b40a7c32e7006dfb94d9c9032cddc319
https://pubmed.ncbi.nlm.nih.gov/23553925
https://pubmed.ncbi.nlm.nih.gov/23553925