The Role of the Respiratory Microbiome and Viral Presence in Lower Respiratory Tract Infection Severity in the First Five Years of Life

Autor: Ivo Hoefnagels, Josephine van de Maat, Jeroen J.A. van Kampen, Annemarie van Rossum, Charlie Obihara, Gerdien A. Tramper-Stranders, Astrid P. Heikema, Willem de Koning, Anne-Marie van Wermerskerken, Deborah Horst-Kreft, Gertjan J.A. Driessen, Janine Punt, Frank J. Smit, Andrew Stubbs, Jeroen G. Noordzij, John P. Hays, Rianne Oostenbrink

Publikováno v: Microorganisms, Vol 9, Iss 7, p 1446 (2021)

Lower respiratory tract infections (LRTIs) in children are common and, although often mild, a major cause of mortality and hospitalization. Recently, the respiratory microbiome has been associated with both susceptibility and severity of LRTI. In thi

Externí odkaz: https://doaj.org/article/25e123459fdb4646b453e7a3d481cf15

The Role of the Respiratory Microbiome and Viral Presence in Lower Respiratory Tract Infection Severity in the First Five Years of Life

Autor: Astrid P. Heikema, Janine Punt, John P. Hays, Gerdien A. Tramper-Stranders, Frank J Smit, Anne-Marie van Wermerskerken, Willem de Koning, Ivo Hoefnagels, Annemarie M. C. van Rossum, Rianne Oostenbrink, Charlie C. Obihara, Andrew P. Stubbs, Josephine van de Maat, Deborah Horst-Kreft, Jeroen J. A. van Kampen, GJ Driessen, Jeroen G. Noordzij

Publikováno v: Microorganisms, Vol 9, Iss 1446, p 1446 (2021)
Microorganisms, 9(7). Multidisciplinary Digital Publishing Institute (MDPI)
Microorganisms, 9(7):1446. Multidisciplinary Digital Publishing Institute (MDPI)
Microorganisms
Volume 9
Issue 7

Lower respiratory tract infections (LRTIs) in children are common and, although often mild, a major cause of mortality and hospitalization. Recently, the respiratory microbiome has been associated with both susceptibility and severity of LRTI. In thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59311a48c2a3bcbfd5f79015063fd70
https://www.mdpi.com/2076-2607/9/7/1446

Campylobacter jejuni Cas9 Modulates the Transcriptome in Caco-2 Intestinal Epithelial Cells

Autor: Rogier Louwen, Chinmoy Saha, Peter J. van der Spek, Inez Kross, Peter van Baarlen, Deborah Horst-Kreft

Publikováno v: Genes
Genes, 11(10)
Volume 11
Issue 10
Genes, Vol 11, Iss 1193, p 1193 (2020)
Genes, 11(10):1193. Multidisciplinary Digital Publishing Institute (MDPI)
Genes 11 (2020) 10

The zoonotic human pathogen Campylobacter jejuni is known for its ability to induce DNA-damage and cell death pathology in humans. The molecular mechanism behind this phenomenon involves nuclear translocation by Cas9, a nuclease in C. jejuni (CjeCas9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b17d460856555d44e0ac83b7f4aa79
http://europepmc.org/articles/PMC7650535

Guide-free Cas9 from pathogenic

Autor: Chinmoy, Saha, Prarthana, Mohanraju, Andrew, Stubbs, Gaurav, Dugar, Youri, Hoogstrate, Gert-Jan, Kremers, Wiggert A, van Cappellen, Deborah, Horst-Kreft, Charlie, Laffeber, Joyce H G, Lebbink, Serena, Bruens, Duncan, Gaskin, Dior, Beerens, Maarten, Klunder, Rob, Joosten, Jeroen A A, Demmers, Dik, van Gent, Johan W, Mouton, Peter J, van der Spek, John, van der Oost, Peter, van Baarlen, Rogier, Louwen

Publikováno v: Science Advances

CjeCas9 causes DNA damage in human cells.
CRISPR-Cas9 systems are enriched in human pathogenic bacteria and have been linked to cytotoxicity by an unknown mechanism. Here, we show that upon infection of human cells, Campylobacter jejuni secretes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6c0f281b94dbe6686799912bc9dbc312
https://pubmed.ncbi.nlm.nih.gov/32596446

Siglec-7 specifically recognizes Campylobacter jenuni strains associated with oculomotor weakness in Guillain-Barre syndrome and Miller Fisher syndrome

Autor: Deborah Horst-Kreft, Bart C. Jacobs, Ruth Huizinga, W.J.B. van Wamel, Hubert P. Endtz, Janneke N. Samsom, Mark L. Kuijf, Astrid P. Heikema

Publikováno v: Clinical Microbiology and Infection, 19, E106-E112. Elsevier Ltd.

Due to molecular mimicry, Campylobacter jejuni lipo-oligosaccharides can induce a cross-reactive antibody response to nerve gangliosides, which leads to Guillain–Barré syndrome (GBS). Cross-reactive antibodies to ganglioside GQ1b are strongly asso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e171537114a5ba9666556c21dc5bb9a0
https://hdl.handle.net/1765/38528