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of 3
pro vyhledávání: '"Deborah Holstein"'
Autor:
Mariana Bollo, R Madelaine Paredes, Deborah Holstein, Nadezhda Zheleznova, Patricia Camacho, James D Lechleiter
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e11925 (2010)
The accumulation of misfolded proteins within the endoplasmic reticulum (ER) triggers a cellular process known as the Unfolded Protein Response (UPR). One of the earliest responses is the attenuation of protein translation. Little is known about the
Externí odkaz:
https://doaj.org/article/e0d55b7d22e64f2a891e9a637f0df303
Autor:
Constanza Feliziani, Macarena Fernandez, Gonzalo Quassollo, Deborah Holstein, Sebastián M Bairo, James C Paton, Adrienne W Paton, Juan de Batista, James D Lechleiter, Mariana Bollo
Publikováno v:
Cell Calcium
The accumulation of unfolded proteins within the Endoplasmic Reticulum (ER) activates a signal transduction pathway termed the unfolded protein response (UPR), which attempts to restore ER homeostasis. If this cannot be done, UPR signalling ultimatel
Autor:
Stuart J. Conway, J. Deborah Holstein, Jun Wu, Geeta Upadhyay, James D. Lechleiter, Da Ting Lin, Elizabeth Muller
Publikováno v:
Journal of Neuroscience. 27:6510-6520
Astrocytes play an essential role in the maintenance and protection of the brain, which we reported was diminished with age. Here, we demonstrate that activation of a purinergic receptor (P2Y-R) signaling pathway, in astrocytes, significantly increas