Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Deborah Heyl"'
Autor:
Ben Haddad, Jeneen Khalil, Hind Al Khashali, Ravel Ray, Stuti Goel, Ban Darweesh, Kai-ling Coleman, Caroline Wozniak, Robert Ranzenberger, Brooke Lopo, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Previously, we found that the levels of soluble amyloid precursor protein α (sAPPα) are regulated, in part, by acetylcholinesterase (AChE) in human A549 (p53 wild-type) and H1299 (p53-null) NSCLC cell lines. In this study, we found regulat
Externí odkaz:
https://doaj.org/article/a2476713c7254f3ca4829719b4de6d2f
Autor:
Hind Al Khashali, Ravel Ray, Ban Darweesh, Caroline Wozniak, Ben Haddad, Stuti Goel, Issah Seidu, Jeneen Khalil, Brooke Lopo, Nayrooz Murshed, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 5033 (2024)
Several studies have shown an inverse correlation between the likelihood of developing a neurodegenerative disorder and cancer. We previously reported that the levels of amyloid beta (Aβ), at the center of Alzheimer’s disease pathophysiology, are
Externí odkaz:
https://doaj.org/article/e365adc9d1044669aecfecb746a4a4bf
Autor:
Ravel Ray, Stuti Goel, Hind Al Khashali, Ban Darweesh, Ben Haddad, Caroline Wozniak, Robert Ranzenberger, Jeneen Khalil, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans
Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2555 (2023)
The ectodomain of the transmembrane protein E-cadherin can be cleaved and released in a soluble form referred to as soluble E-cadherin, or sE-cad, accounting for decreased E-cadherin levels at the cell surface. Among the proteases implicated in this
Externí odkaz:
https://doaj.org/article/c40b90e6e782438aa0cf6fbcb08e8cfe
Autor:
Sadaf Dorandish, Asana Williams, Sarah Atali, Sophia Sendo, Deanna Price, Colton Thompson, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-22 (2021)
Abstract In this study, we set out to identify regulators of intact amyloid-β40/42 (Aβ) levels in A549 (p53 wild-type) and H1299 (p53-null) lung cancer cell media. Higher Aβ levels were detected in the media of A549 than H1299 cells without or wit
Externí odkaz:
https://doaj.org/article/d44d3e5714664754893ba718f40c07d2
Autor:
Kai-ling Coleman, Michael Chiaramonti, Ben Haddad, Robert Ranzenberger, Heather Henning, Hind Al Khashali, Ravel Ray, Ban Darweesh, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans
Publikováno v:
Cells, Vol 12, Iss 3, p 405 (2023)
Cisplatin is a platinum agent used in the treatment of non-small cell lung cancer (NSCLC). Much remains unknown regarding the basic operative mechanisms underlying cisplatin resistance in NSCLC. In this study, we found that phosphorylation of IGFBP-3
Externí odkaz:
https://doaj.org/article/5747bbaaf1524a279dddddc6d2114c62
Autor:
Hind Al Khashali, Jadziah Wareham, Ravel Ray, Ben Haddad, Kai-Ling Coleman, Robert Ranzenberger, Patrick McCombs, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans
Publikováno v:
Cells, Vol 11, Iss 22, p 3533 (2022)
In this study, we examined the roles of heparanase and IGFBP-3 in regulating A549 and H1299 non-small-cell lung cancer (NSCLC) survival. We found that H1299 cells, known to be p53-null with no expression of IGFBP-3, had higher heparanase levels and a
Externí odkaz:
https://doaj.org/article/5e5b41d03c05467f8e94d34253b7d251
Autor:
Ravel Ray, Hind Al Khashali, Ben Haddad, Jadziah Wareham, Kai-Ling Coleman, Danyah Alomari, Robert Ranzenberger, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 12829 (2022)
It is well-recognized that cigarette smoking is a primary risk factor in the development of non-small cell lung cancer (NSCLC), known to account for ~80% of all lung cancers with nicotine recognized as the major addictive component. In investigating
Externí odkaz:
https://doaj.org/article/d3ea212379724065998a99f88db97070
Autor:
Hind Al Khashali, Ravel Ray, Kai-Ling Coleman, Sarah Atali, Ben Haddad, Jadziah Wareham, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10746 (2022)
In comparing two human lung cancer cells, we previously found lower levels of acetylcholinesterase (AChE) and intact amyloid-β40/42 (Aβ), and higher levels of mature brain-derived neurotrophic factor (mBDNF) in the media of H1299 cells as compared
Externí odkaz:
https://doaj.org/article/3c56555479504fa1b61bfb33f8977044
Autor:
Sadaf Dorandish, Sarah Atali, Ravel Ray, Hind Al Khashali, Kai-Ling Coleman, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 7059 (2021)
Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, has been linked to several human malignancies and shown to promote tumorigenesis. The purpose of this study was to explore the relative abundance of pro-brain-derived neur
Externí odkaz:
https://doaj.org/article/8e18f382b62d4a8baba2664460ab7625
Autor:
Kai‐ling E. Coleman, Hind Al Khashali, Ravel Ray, Sarah Atali, Sadaf Dorandish, Jeffrey Guthrie, Deborah Heyl, Hedeel G. Evans
Publikováno v:
The FASEB Journal. 36