Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Deborah Hatherley"'
Autor:
Jamie Rossjohn, Jan Petersen, Peter Jönsson, Victoria Junghans, Simon J. Davis, Ana Filipa L.O.M. Santos, Deborah Hatherley, Manto Chouliara, Tommy Dam, Lena Svensson
Publikováno v:
Journal of Cell Science
he affinity of T-cell receptors (TCRs) for major histocompatibility complex molecules (MHCs) presenting cognate antigens likely determines whether T cells initiate immune responses, or not. There exist few measurements of two-dimensional (2D) TCR–M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e41ed6f2a4704f947d03d379b01347b
https://pubmed.ncbi.nlm.nih.gov/32591485
https://pubmed.ncbi.nlm.nih.gov/32591485
Autor:
Christian Eggeling, Edward Jenkins, Erdinc Sezgin, Simon J. Davis, James H. Felce, Deborah Hatherley, Michael L. Dustin, Ana Filipa L.O.M. Santos
The spatiotemporal regulation of signalling proteins at the contacts formed between immune cells and their targets determines how and when immune responses begin and end. It is important, therefore, to be able to elucidate molecular processes occurri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75be4830d97f31533f7cbb2c9ffa24da
https://doi.org/10.1101/311399
https://doi.org/10.1101/311399
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1584
Innate and adaptive cellular immunity is dependent on interactions of cell surface receptors that initiate signaling, resulting in the formation of the immunological synapse and targeted delivery of effector functions. There has been considerable int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3afcdcf9b5bb2bfdc9693624469bcacc
https://pubmed.ncbi.nlm.nih.gov/28255719
https://pubmed.ncbi.nlm.nih.gov/28255719
Publikováno v:
The Immune Synapse ISBN: 9781493968794
Innate and adaptive cellular immunity is dependent on interactions of cell surface receptors that initiate signaling, resulting in the formation of the immunological synapse and targeted delivery of effector functions. There has been considerable int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d94b4bee7197831d2a0b7daf7fc580d
https://doi.org/10.1007/978-1-4939-6881-7_28
https://doi.org/10.1007/978-1-4939-6881-7_28
Publikováno v:
Structure(London, England:1993)
Summary CD200 is a widely distributed membrane glycoprotein that regulates myeloid cell activity through its interaction with an inhibitory receptor (CD200R). The interaction is of interest as a target for treating excessive inflammation and for trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1508bd67c6f0d3470aea9b60e276b6a
Publikováno v:
Immunology
One common way to study human leucocytes and cancer cells in an experimental in vivo situation is to use mice that have been genetically engineered to lack an immune system and prevent human cell rejection. These mice lack CD132 and either RAG2 or th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed43a0d2159a72424f4d4aefe5dbcc6
https://doi.org/10.1111/imm.12290
https://doi.org/10.1111/imm.12290
Publikováno v:
The Journal of Biological Chemistry
Signal-regulatory protein alpha (SIRPalpha) is a myeloid membrane receptor that interacts with the membrane protein CD47, a marker of self. We have solved the structure of the complete extracellular portion of SIRPalpha, comprising three immunoglobul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f07ba80dad19bfaca66a46bbc37212
http://europepmc.org/articles/PMC2785349
http://europepmc.org/articles/PMC2785349
Autor:
Joanne E. Nettleship, David J. Scott, A. Neil Barclay, Jingshan Ren, Raymond J. Owens, Deborah Hatherley, David I. Stuart, Nahid Rahman, Yuguang Zhao
Publikováno v:
BMC Structural Biology
Background Signal Regulatory Protein γ (SIRPγ) is a member of a closely related family of three cell surface receptors implicated in modulating immune/inflammatory responses. SIRPγ is expressed on T lymphocytes where it appears to be involved in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8fbb45ab78b62717b36e993680bfbe
https://doi.org/10.1186/1472-6807-13-13
https://doi.org/10.1186/1472-6807-13-13
Autor:
A. Neil Barclay, Deborah Hatherley
Publikováno v:
Immunity. 29(5)
Paired receptors are families of membrane proteins containing similar extracellular regions but differing in their potential for signaling with one type able to give inhibitory signals and the other activating. Inhibitory receptors could be good targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1fee7163276f64aff5470319213968
http://ora.ox.ac.uk/objects/uuid:e0e62b92-e8d3-4784-9dc3-e39ca152c331
http://ora.ox.ac.uk/objects/uuid:e0e62b92-e8d3-4784-9dc3-e39ca152c331
Autor:
Raymond J. Owens, Joanne E. Nettleship, A. Neil Barclay, Jingshan Ren, Deborah Hatherley, Nick S. Berrow, Nahid Rahman
Publikováno v:
Protein expression and purification. 62(1)
We describe a pipeline for the rapid production of recombinant Fabs derived from mouse monoclonal antibodies suitable for use in structural studies. The pipeline is exemplified by the production of three Fabs derived from the monoclonal antibodies OX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4870aa8fceb680ba58eeb847f668bcd6
http://ora.ox.ac.uk/objects/uuid:4d0263d0-d23d-493f-aa57-ce42f324a29c
http://ora.ox.ac.uk/objects/uuid:4d0263d0-d23d-493f-aa57-ce42f324a29c