Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Deborah H. Slee"'
Autor:
Vivek Gupta, Deborah H. Slee, Ming Chen, John A. Muraski, Samir Mitragotri, Sunny Kumar, Aaron C. Anselmo
Publikováno v:
Journal of Controlled Release. 199:190-197
Cyclosporine A (CsA) is used for the treatment of psoriasis; however systemic administration of CsA is potentially life threatening and there are long-term side effects. Topical application of CsA has the potential to overcome this hurdle; however, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32799c449587c29c7b6420cda77771a5
https://doi.org/10.1016/j.jconrel.2014.11.015
https://doi.org/10.1016/j.jconrel.2014.11.015
Autor:
Deborah H. Slee, Ming Chen, Samir Mitragotri, John A. Muraski, Michael Zakrewsky, Aaron C. Anselmo, Vivek Gupta
Publikováno v:
Journal of Controlled Release. 179:33-41
Short-interfering RNAs (siRNAs) offer a potential tool for the treatment of skin disorders. However, applications of siRNA for dermatological conditions are limited by their poor permeation across the stratum corneum of the skin and low penetration i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f472c7f030b8f58b7a8a2de77c1b305e
https://doi.org/10.1016/j.jconrel.2014.01.006
https://doi.org/10.1016/j.jconrel.2014.01.006
Autor:
Marion Lanier, Xiaohu Zhang, John E. Tellew, Zhiyong Luo, Mark Santos, Raymond S. Gross, Deborah H. Slee, Emily Lin, Sandra M. Lechner, Jaimie K. Rueter, María I. Crespo, Jose-Luis Diaz, Yongsheng Chen, Siobhan Malany, Manisha Moorjani, John Saunders, John P. Williams, Binh G. Vong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5402-5405
In this report, the strategy and outcome of expanding SAR exploration to improve solubility and metabolic stability are discussed. Compound 35 exhibited excellent potency, selectivity over A(1) and improved solubility of >4 mg/mL at pH 8.0. In additi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799d40e0876b3b15e810f1648d5b9dc2
https://doi.org/10.1016/j.bmcl.2008.09.048
https://doi.org/10.1016/j.bmcl.2008.09.048
Publikováno v:
Neuropsychopharmacology. 34:106-125
Beginning with the discovery of the structure of deoxyribose nucleic acid in 1953, by James Watson and Francis Crick, the sequencing of the entire human genome some 50 years later, has begun to quantify the classes and types of proteins that may have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723ea08dfedddb19a8b42c3d17dcbde5
https://doi.org/10.1038/npp.2008.149
https://doi.org/10.1038/npp.2008.149
Autor:
Yongsheng Chen, Mark Santos, Emily Lin, Stacy Markison, John E. Tellew, Sandra M. Lechner, Maria Prat, Xiaohu Zhang, John Saunders, Silvia Gual, Marion Lanier, Marı´a I. Crespo, John P. Williams, Raymond S. Gross, Tanya Joswig, Jaimie K. Rueter, Deborah H. Slee, Siobhan Malany, Jose-Luis Diaz, Manisha Moorjani, Julio C. Castro-Palomino
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1778-1783
A series of N-pyrimidinyl-2-phenoxyacetamide adenosine A(2A) antagonists is described. SAR studies led to compound 14 with excellent potency (K(i) = 0.4 nM), selectivity (A(1)/A(2A) > 100), and efficacy (MED 10 mg/kg p.o.) in the rat haloperidol-indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26dca2261358c58ec30c26ccccacb9f1
https://doi.org/10.1016/j.bmcl.2008.02.032
https://doi.org/10.1016/j.bmcl.2008.02.032
Autor:
Deborah H. Slee, Susan K. Sullivan, Neil J. Ashweek, Marion Lanier, Yun-Fei Zhu, Jaimie K. Rueter, Miklos Feher, Colin J. Loweth, Michael S. Brown, John P. Williams
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:5590-5603
The present article describes a selection of a new class of small molecule antagonists for the h-GnRH receptor, their preparation, and evaluation in vitro. Three computational methods were combined into a consensus score, to rank order virtual templa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226de7983d180f332e8e5ee93f98fa99
https://doi.org/10.1016/j.bmc.2007.05.029
https://doi.org/10.1016/j.bmc.2007.05.029
Autor:
William Charles Ripka, Scott W. Nelson, Kevin M. Short, Michael J. Newman, Richard B. Honzatko, Karl Norvell, Frank U. Axe, Kristen L. Arienti, Deborah H. Slee, Tassie L. Collins, Todd K. Jones, Jun-young Choe, Herbert J. Fromm, Rachel Denise Anne Kimmich, Suzanne J. Romano
Publikováno v:
Journal of Biological Chemistry. 278:51176-51183
A highly constrained pseudo-tetrapeptide (OC252-324) further defines a new allosteric binding site located near the center of fructose-1,6-bisphosphatase. In a crystal structure, pairs of inhibitory molecules bind to opposite faces of the enzyme tetr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea24c33701eda690081ee60805f1970
https://doi.org/10.1074/jbc.m308396200
https://doi.org/10.1074/jbc.m308396200
Autor:
Alexander Wlodawer, Alla Gustchina, Deborah H. Slee, Ian R. Ollmann, Chi-Huey Wong, Karen Laslo, Jukka Kervinen, John H. Elder, Alexander Zdanov
Publikováno v:
Journal of the American Chemical Society. 117:11867-11878
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3a5b210b7fc9b9aa315d4098cd8a73c
https://doi.org/10.1021/ja00153a008
https://doi.org/10.1021/ja00153a008
Autor:
Deborah H. Slee, Truc N. Nguyen, Mary Kish, Michael J. Newman, Stephen J. Mcconnell, Katy Lundeen, Abhijit S. Bhat
Publikováno v:
Journal of Medicinal Chemistry. 46:1120-1122
The regulation of lipid metabolism and it's effect on glucose control and diabetes has received intense interest. Hormone-sensitive lipase (HSL) is a vital enzyme in lipid metabolism. A series of novel pyrrolopyrazinediones has been discovered that d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2046b588813d72007c3ddeb94024cc9
https://doi.org/10.1021/jm020460y
https://doi.org/10.1021/jm020460y
Autor:
Emily Lin, Zhiyong Luo, Dimitri E. Grigoriadis, Marion Lanier, Xiaohu Zhang, Romano Di Fabio, Yves St. Denis, John E. Tellew, Enza Di Modugno, John Saunders, Deborah H. Slee, John P. Williams, Sam R. J. Hoare, Manisha Moorjani
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(24)
Antagonists of the corticotropin-releasing factor (CRF) neuropeptide may prove effective in treating stress and anxiety related disorders. In an effort to identify antagonists with improved physico-chemical properties a new series of CRF1 antagonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62fe3390acd888ced83d813e4ac50c4a
https://pubmed.ncbi.nlm.nih.gov/21074436
https://pubmed.ncbi.nlm.nih.gov/21074436