Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Deborah H. Anderson"'
Autor:
Riley Plett, Paul Mellor, Stephanie Kendall, S. Austin Hammond, Aren Boulet, Kristine Plaza, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Deborah H. Anderson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract The lack of targeted therapies for triple-negative breast cancer (TNBC) contributes to their high mortality rates and high risk of relapse compared to other subtypes of breast cancer. Most TNBCs (75%) have downregulated the expression of CRE
Externí odkaz:
https://doaj.org/article/186e1e23d6a14840ad9f12c034534a4f
Autor:
Paul Mellor, Jeremy D. S. Marshall, Xuan Ruan, Dielle E. Whitecross, Rebecca L. Ross, Margaret A. Knowles, Stanley A. Moore, Deborah H. Anderson
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract The p85α protein regulates flux through the PI3K/PTEN signaling pathway, and also controls receptor trafficking via regulation of Rab-family GTPases. In this report, we determined the impact of several cancer patient-derived p85α mutations
Externí odkaz:
https://doaj.org/article/623db4a84b7e4de981307ebca5478389
Autor:
Shari E. Smith, Paul Mellor, Alison K. Ward, Stephanie Kendall, Megan McDonald, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Scott Napper, Deborah H. Anderson
Publikováno v:
Breast Cancer Research, Vol 19, Iss 1, Pp 1-12 (2017)
Abstract Background Breast cancer cell lines are frequently used as model systems to study the cellular properties and biology of breast cancer. Our objective was to characterize a large, commonly employed panel of breast cancer cell lines obtained f
Externí odkaz:
https://doaj.org/article/2aff98d9ac904e79a37799d4b8cac4cb
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Hepatitis C virus (HCV) infection leads to severe liver diseases including hepatocellular carcinoma (HCC). Phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a tumour suppressor, is frequently mutated or deleted in HCC tumors. P
Externí odkaz:
https://doaj.org/article/e305dffddbc14d72893bba40e8877883
Publikováno v:
Biomolecules, Vol 9, Iss 1, p 29 (2019)
The phosphatidylinositol 3-kinase (PI3K) pathway plays a central role in the regulation of cell signaling, proliferation, survival, migration and vesicle trafficking in normal cells and is frequently deregulated in many cancers. The p85α protein is
Externí odkaz:
https://doaj.org/article/53583cf2741c451f9cc2a3e0212a2927
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271090 (2022)
Women with metastatic breast cancer have a disheartening 5-year survival rate of only 28%. CREB3L1 (cAMP-responsive element binding protein 3 like 1) is a metastasis suppressor that functions as a transcription factor, and in an estrogen-dependent mo
Externí odkaz:
https://doaj.org/article/20664500fc124fd7aa17581a20256e99
Autor:
Raghuveera Kumar Goel, Frederick S. Vizeacoumar, Gerald F. Davies, Kiven Erique Lukong, Edward T. Bagu, Chenlu Dai, Alison K Ward, Sayem Miah, Deborah H. Anderson, Yetunde Ogunbolude, Franco J. Vizeacoumar
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)
BMC Cancer
BMC Cancer
Background BRK is, a non-receptor tyrosine kinase, overexpressed in approximately 85% of human invasive ductal breast tumors. It is not clear whether BRK expression correlates with breast cancer subtypes, or the expression has prognostic or diagnosti
Autor:
Jeremy D. S. Marshall, Xuan Ruan, Dielle E. Whitecross, Paul Mellor, Deborah H. Anderson, Stanley A. Moore
Publikováno v:
Oncotarget
The phosphatidylinositol 3-kinase (PI3K) pathway plays a key role in regulating cell growth and cell survival and is frequently deregulated in cancer cells. p85α regulates the p110α lipid kinase, and also stabilizes and stimulates PTEN, the lipid p
Autor:
Deborah H. Anderson
Breast cancer is the most common cancer in women and the second leading cause of death in women due to cancer. The majority (~ 70%) of breast cancers are of the luminal A subtype, defined by the expression of the estrogen receptor (ER +), but lacking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2448bed8fb71e6d959cd7d6586850c02
https://doi.org/10.1016/b978-0-12-821310-0.00010-3
https://doi.org/10.1016/b978-0-12-821310-0.00010-3
Autor:
Deborah H. Anderson, David N. Brindley, Artem Cherkasov, Mackenzie L. Coatham, E. Dadachova, Shoukat Dedhar, Vincenzo Giambra, Juha P. Himanen, Michael Jewer, Madhuri Koti, Nathan A. Lack, Xueqing Lun, Paul C. McDonald, Jennifer M. Nagel, Dimitar B. Nikolov, Alisha Poole, Lynne-Marie Postovit, Afshin Raouf, Stephen M. Robbins, Hilal Saraç, Donna L. Senger, Noor Shakfa, Peter M. Siegel, D. Robert Siemens, Francesco Tamiro, Josie Ursini-Siegel, Andrew P. Weng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05037e925fddfa0d06394838a5c405b2
https://doi.org/10.1016/b978-0-12-821310-0.09987-3
https://doi.org/10.1016/b978-0-12-821310-0.09987-3