Výsledky vyhledávání - "Deborah H, Smith"

Distinct functional and conformational states of the human lymphoid tyrosine phosphatase catalytic domain can be targeted by choice of the inhibitor chemotype

Autor: Dusica Vidovic, Donald W. Landry, Stephan C. Schürer, Deborah H. Smith, Yuli Xie, Caty Chung, Lutz Tautz, Alison Rinderspacher, Shi Xian Deng

Publikováno v: J Comput Aided Mol Des

The lymphoid tyrosine phosphatase (LYP), encoded by the PTPN22 gene, has recently been identified as a promising drug target for human autoimmunity diseases. Like the majority of protein-tyrosine phosphatases LYP can adopt two functionally distinct f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478ada35d73e2ed02b0696006b256c35
https://doi.org/10.1007/s10822-011-9469-2

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The alpha-synuclein 5′untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen

Autor: Catherine M. Cahill, Debomoy K. Lahiri, Deborah H. Smith, Sohan Mikkilineni, Nigel H. Greig, Xudong Huang, Jack T. Rogers, Ippolita Cantuti-Castelvetri, Sanghamitra Bandyopadhyay, Maria L. Maccecchini

Publikováno v: Journal of Neural Transmission. 118:493-507

Increased brain α-synuclein (SNCA) protein expression resulting from gene duplication and triplication can cause a familial form of Parkinson’s disease (PD). Dopaminergic neurons exhibit elevated iron levels that can accelerate toxic SNCA fibril f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b36ec5059a07ff95c597985646617f
https://doi.org/10.1007/s00702-010-0513-5

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Small-Molecule Modulators of the NF-κB Pathway Newly Identified by a Translocation-Based Cellular Assay

Autor: Yidong Liu, Lars Branden, Gangli Gong, Shi Xian Deng, Yuli Xie, Deborah H. Smith, Michael Wyler, Alison Rinderspacher

Publikováno v: Current Topics in Medicinal Chemistry. 9:1172-1180

Nuclear factor kappa B (NF-κB) is an important transcription factor. Aberrant regulation of the NF-κB pathway is frequently observed in a number of major ailments such as cancer and inflammatory diseases. Hence NF-κB modulators have been intensely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e0c75f368dbe8757d1ed52bdc056b4d
https://doi.org/10.2174/156802609789753617

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Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation

Autor: Alison Rinderspacher, Michael Wyler, Stephan C. Schürer, Yuli Xie, Nathalie Aulner, Dusica Vidovic, Udo Toebben, Lars Branden, Gangli Gong, Yan Feng, Deborah H. Smith, Zhengxiang Zhu, Donald W. Landry, Yidong Liu, Shi Xian Deng, Yufei Tang, Caty Chung

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:1191-1194

An IKKbeta inhibitor reported to block NF-kappaB transcriptional activities in Jurkat T cells, was found to enhance NF-kappaB translocation in HUVEC cells. These studies suggested a noncanonical NF-kappaB signaling pathway independent of IKKbeta in H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1285af77ce8a6aa608ffaa1eac4f1f84
https://doi.org/10.1016/j.bmcl.2008.12.086

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Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease

Autor: Catherine M. Cahill, Xudong Huang, Peter J. Leedman, Ashley I. Bush, Avi L. Friedlich, Debomoy K. Lahiri, Hyan-Hee Cho, Andrew M. Thomson, Deborah H. Smith, Jack T. Rogers

Publikováno v: Biochemical Society Transactions. 36:1282-1287

The essential metals iron, zinc and copper deposit near the Aβ (amyloid β-peptide) plaques in the brain cortex of AD (Alzheimer's disease) patients. Plaque-associated iron and zinc are in neurotoxic excess at 1 mM concentrations. APP (amyloid precu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38db57e7fe68c5615be2bd8fb396c303
https://doi.org/10.1042/bst0361282

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High-Level Expression of Rabbit 15-Lipoxygenase Induces Collapse of the Mitochondrial pH Gradient in Cell Culture

Autor: Martin Wiedmann, Dino A. De Angelis, Robert M. Duvoisin, Deborah H. Smith, Matthias Walther, Chetan Vijayvergiya, Hartmut Kühn

Publikováno v: Biochemistry. 43:15296-15302

A critical step in the development of mammalian erythroblasts into mature red blood cells is the extrusion of the nucleus, followed by intracellular degradation of the remaining organelles. It has been hypothesized that the breakdown of cellular orga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e3bd994fa656a02bce680d3f830e39
https://doi.org/10.1021/bi048745v

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